Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

(2017) J Chu et al.   MOLECULAR PSYCHIATRY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

(2017) Mathieu Coureuil et al.   NATURE REVIEWS MICROBIOLOGY

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

(2017) Rui Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence

(2016) Yue Zhao et al.   CURRENT OPINION IN MICROBIOLOGY

Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis

(2016) Jason C. Lenzo et al.   INFECTION AND IMMUNITY

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology

(2015) Joseph M. Replogle et al.   ANNALS OF NEUROLOGY

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

The Morbidity, Mortality, and Costs Associated with Clostridium difficile Infection

(2015) Jennie H. Kwon et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Assessing fibrinogen extravasation into Alzheimer's disease brain using high-content screening of brain tissue microarrays

(2015) Pritika J. Narayan et al.   JOURNAL OF NEUROSCIENCE METHODS

A small-molecule antivirulence agent for treating Clostridium difficile infection

(2015) Kristina Oresic Bender et al.   Science Translational Medicine

Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry

(2014) T. McAvoy et al.   CLINICAL CHEMISTRY

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Can Infections Cause Alzheimer's Disease?

(2013) F. Mawanda et al.   EPIDEMIOLOGIC REVIEWS

NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese

(2013) Meng-Shan Tan et al.   JOURNAL OF NEUROIMMUNOLOGY

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Distribution of periodontopathic bacterial species in dogs and their owners

(2012) Y. Yamasaki et al.   ARCHIVES OF ORAL BIOLOGY

Porphyromonas gingivalis influences actin degradation within epithelial cells during invasion and apoptosis

(2012) James A. Kinane et al.   CELLULAR MICROBIOLOGY

Porphyromonas gingivalis as a Potential Community Activist for Disease

(2012) R.P. Darveau et al.   JOURNAL OF DENTAL RESEARCH

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Infections and immunodeficiency in Down syndrome

(2011) G. Ram et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Tau Truncation is a Productive Posttranslational Modification of Neurofibrillary Degeneration in Alzheimers Disease

(2010) B. Kovacech et al.   Current Alzheimer Research

Tooth Loss and Periodontal Disease Predict Poor Cognitive Function in Older Men

(2010) Elizabeth Krall Kaye et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon’s knife to a meat chopper-like brutal degradation of proteins

(2010) Yonghua Guo et al.   PERIODONTOLOGY 2000

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

(2009) Panagiota G Stathopoulou et al.   BMC MICROBIOLOGY

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Localization of P. gingivalis in Preterm Delivery Placenta

(2009) J. Katz et al.   JOURNAL OF DENTAL RESEARCH

Critical Role of Apoptotic Speck Protein Containing a Caspase Recruitment Domain (ASC) and NLRP3 in Causing Necrosis and ASC Speck Formation Induced by Porphyromonas gingivalis in Human Cells

(2009) M. T.-H. Huang et al.   JOURNAL OF IMMUNOLOGY

Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III

(2009) J M Noble et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gingivalis

(2008) Ling Li et al.   BMC MICROBIOLOGY