The discovery of proteases and intramembrane proteolysis

Latest emerging functions of SPP/SPPL intramembrane proteases

(2017) Torben Mentrup et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

(2017) Nicholas Johnson et al.   Scientific Reports

Probing catalytic rate enhancement during intramembrane proteolysis

(2016) Elena Arutyunova et al.   BIOLOGICAL CHEMISTRY

Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4

(2016) Sandra Paschkowsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Rhomboid proteases in invasion and replication of Apicomplexa

(2015) Rebecca J. Stewart et al.   MOLECULAR MICROBIOLOGY

Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

(2015) Wei Song et al.   Nature Communications

Molecular mechanism of intramembrane proteolysis by γ-secretase

(2014) Taisuke Tomita   JOURNAL OF BIOCHEMISTRY

Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion

(2014) B. Shen et al.   mBio

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The pathological significance of Notch1 in oral squamous cell carcinoma

(2013) Ryoji Yoshida et al.   LABORATORY INVESTIGATION

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

(2013) Ioannis Manolaridis et al.   NATURE

Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad

(2013) A. R. Buller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

(2011) Guang Shi et al.   HUMAN MOLECULAR GENETICS

Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate

(2011) Yi Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved water-mediated H-bonding dynamics of catalytic His159 and Asp158: insight into a possible acid–base coupled mechanism in plant thiol protease

(2011) Tapas K. Nandi et al.   JOURNAL OF MOLECULAR MODELING

Identification and characterization of a bacterial glutamic peptidase

(2010) Kenneth Jensen et al.   BMC BIOCHEMISTRY

Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Rhomboid Protease PARL

(2010) Anthony E. Civitarese et al.   Cell Metabolism

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the  -Secretase

(2010) S. Takagi et al.   JOURNAL OF NEUROSCIENCE

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

Excitement grows for potential revolution in hepatitis C virus treatment

(2010) Alisa Opar   NATURE REVIEWS DRUG DISCOVERY

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

(2009) Markus Almén et al.   BMC BIOLOGY

Intramembrane-cleaving Proteases

(2009) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

Rhomboid Protease Dynamics and Lipid Interactions

(2009) Ana-Nicoleta Bondar et al.   STRUCTURE

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY