Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

(2015) Muriel Arimon et al.   NEUROBIOLOGY OF DISEASE

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-  and Epidermal Growth Factor

(2014) C. Arduise et al.   JOURNAL OF IMMUNOLOGY

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease

(2012) Lara Wahlster et al.   ACTA NEUROPATHOLOGICA

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

(2012) Yasuhiro Teranishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10

(2012) Johannes Prox et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Pancortins interact with amyloid precursor protein and modulate cortical cell migration

(2012) H. C. Rice et al.   DEVELOPMENT

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain

(2012) Cary Esselens et al.   FASEB JOURNAL

Notch and the Awesome Power of Genetics

(2012) Iva Greenwald   GENETICS

Identification of Novel γ-Secretase-associated Proteins in Detergent-resistant Membranes from Brain

(2012) Ji-Yeun Hur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Dynamic Analysis of Amyloid  -Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal A  during Age-Related Plaque Formation

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates

(2010) Allen C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells

(2010) C. D. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

(2010) Erik Portelius et al.   Alzheimers Research & Therapy

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase

(2009) Lauren Herl et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY