GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions

(2016) Sandra Favret et al.   Aging-US

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

(2015) Ying Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

(2014) Carla J Aguiar et al.   Cell Communication and Signaling

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

(2014) C. Graf et al.   JOURNAL OF IMMUNOLOGY

G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype

(2014) Klemens Högenauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-Protein–Coupled Receptor 91 and Succinate Are Key Contributors in Neonatal Postcerebral Hypoxia-Ischemia Recovery

(2013) David Hamel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

(2012) Ana Carolina Ariza et al.   Frontiers in Endocrinology

Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9

(2010) Suzan Pae et al.   IMMUNOGENETICS

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

High glucose and renin release: the role of succinate and GPR91

(2010) János Peti-Peterdi   KIDNEY INTERNATIONAL

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation

(2009) Magdalena Koziczak-Holbro et al.   ARTHRITIS AND RHEUMATISM

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE