2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

(2014) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Chromatin and oxygen sensing in the context of JmjC histone demethylases

(2014) Alena Shmakova et al.   BIOCHEMICAL JOURNAL

Interpreting the language of histone and DNA modifications

(2014) Scott B. Rothbart et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

(2014) Hao Wu et al.   CELL

Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth

(2014) Sylvia Koch et al.   CELL CYCLE

Polycomb silencing: from linear chromatin domains to 3D chromosome folding

(2014) Thierry Cheutin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

Effects of the mitochondrial respiratory chain on longevity in C. elegans

(2014) Beverley M. Dancy et al.   EXPERIMENTAL GERONTOLOGY

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human high-altitude adaptation: forward genetics meets the HIF pathway

(2014) Abigail W. Bigham et al.   GENES & DEVELOPMENT

A Role forSaccharomyces cerevisiaeTpa1 Protein in Direct Alkylation Repair

(2014) Gururaj Shivange et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing

(2014) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

(2014) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

(2014) Gary C. Hon et al.   MOLECULAR CELL

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions

(2014) Ho-Youl Lee et al.   MOLECULES AND CELLS

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

Evolution and diversity of the 2-oxoglutarate-dependent dioxygenase superfamily in plants

(2014) Yosuke Kawai et al.   PLANT JOURNAL

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

(2014) M. J. Katz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

(2014) C. Loenarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of Jumonji-type oxygenases in human disease

(2014) Catrine Johansson et al.   Epigenomics

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

(2014) Emily L Putiri et al.   GENOME BIOLOGY

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Role of Vitamin C in the Function of the Vascular Endothelium

(2013) James M. May et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

(2013) Johanna Myllyharju et al.   BIOLOGICAL CHEMISTRY

The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3

(2013) Panu M. Jaakkola et al.   BIOLOGICAL CHEMISTRY

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation

(2013) Lulu Hu et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Breathing-in epigenetic change with vitamin C

(2013) Asun Monfort et al.   EMBO REPORTS

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

(2013) A. E. Teschendorff et al.   HUMAN MOLECULAR GENETICS

Nitric Oxide Modifies Global Histone Methylation by Inhibiting Jumonji C Domain-containing Demethylases

(2013) Jason R. Hickok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of oxygen consumption in hypoxia protection by translation factor depletion

(2013) B. Scott et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex

(2013) Christos Chinopoulos   JOURNAL OF NEUROSCIENCE RESEARCH

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

(2013) A. Tsamis et al.   Journal of the Royal Society Interface

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Chromatin dynamics during cellular reprogramming

(2013) Effie Apostolou et al.   NATURE

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism

(2013) Bailin Zhao et al.   NUCLEIC ACIDS RESEARCH

The Chromatin Remodeling Factor CSB Recruits Histone Acetyltransferase PCAF to rRNA Gene Promoters in Active State for Transcription Initiation

(2013) Meili Shen et al.   PLoS One

Less is more: improving proteostasis by translation slow down

(2013) Michael Y. Sherman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxygen, epigenetic signaling, and the evolution of early life

(2013) Albert Jeltsch   TRENDS IN BIOCHEMICAL SCIENCES

Tudor: a versatile family of histone methylation ‘readers’

(2013) Rui Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

(2013) J. Keith Killian et al.   Cancer Discovery

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

(2013) Francesco Neri et al.   GENOME BIOLOGY

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase

(2012) Elena M. Sánchez-Fernández et al.   BIOCHEMICAL JOURNAL

Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases

(2012) N. A. Smirnova et al.   BIOCHEMISTRY-MOSCOW

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Electronic Structure Analysis of the Oxygen-Activation Mechanism by FeII- and α-Ketoglutarate (αKG)-Dependent Dioxygenases

(2012) Shengfa Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

(2012) Norma Masson et al.   EMBO REPORTS

Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome

(2012) Holger Heyn et al.   Epigenetics

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

The mitochondrial oxoglutarate carrier: from identification to mechanism

(2012) Magnus Monné et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation

(2012) Roberta Leonardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases

(2012) Eun A. Cho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium

(2012) Yana Chervona et al.   Metallomics

RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase

(2012) Conchi Estarás et al.   MOLECULAR BIOLOGY OF THE CELL

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

(2012) Jordana T. Bell et al.   PLoS Genetics

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Tet1 and 5-hydroxymethylation

(2011) Hao Wu et al.   CELL CYCLE

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

(2011) Anjali Nandal et al.   Cell Metabolism

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Lineage-specific distribution of high levels of genomic

(2011) Alexey Ruzov et al.   CELL RESEARCH

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain

(2011) Anup K Upadhyay et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

(2011) C. E. Nestor et al.   GENOME RESEARCH

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Impaired hypoxic response in senescent mouse brain

(2011) Tamer Rabie et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Functional regulation of HIF-1α under normoxia-is there more than post-translational regulation?

(2011) A. Kuschel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

(2011) Hao Wu et al.   NATURE

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

The Histone Demethylase Jarid1b (Kdm5b) Is a Novel Component of the Rb Pathway and Associates with E2f-Target Genes in MEFs during Senescence

(2011) Jeroen H. Nijwening et al.   PLoS One

RNA Sequencing Reveals Differential Expression of Mitochondrial and Oxidation Reduction Genes in the Long-Lived Naked Mole-Rat When Compared to Mice

(2011) Chuanfei Yu et al.   PLoS One

Histone methylation makes its mark on longevity

(2011) Shuo Han et al.   TRENDS IN CELL BIOLOGY

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

(2011) Hume Stroud et al.   GENOME BIOLOGY

Chromatin remodeling in the aging genome of Drosophila

(2010) Jason G. Wood et al.   AGING CELL

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

(2010) Emily Flashman et al.   BIOCHEMICAL JOURNAL

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

(2010) Scott F. Leiser et al.   BIOLOGICAL CHEMISTRY

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase

(2010) X. Zhou et al.   CANCER RESEARCH

Structural studies on human 2-oxoglutarate dependent oxygenases

(2010) Michael A McDonough et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation

(2010) Yuji Tanaka et al.   EMBO JOURNAL

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

(2010) Christoph Loenarz et al.   EMBO REPORTS

OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling

(2010) Ken Saito et al.   FEBS LETTERS

Oxygen Activation at Mononuclear Nonheme Iron Centers: A Superoxo Perspective

(2010) Anusree Mukherjee et al.   INORGANIC CHEMISTRY

Prolyl 3-Hydroxylase 1 Null Mice Display Abnormalities in Fibrillar Collagen-rich Tissues Such as Tendons, Skin, and Bones

(2010) Janice A. Vranka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

(2010) Yee Liu Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2  Phosphorylation and the Cellular Response to Stress

(2010) K. A. Wehner et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)

(2009) Olli Arjamaa et al.   AGEING RESEARCH REVIEWS

Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain

(2009) Obinna I. Ndubuizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing

(2009) James D. Webb et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

(2009) M. Barradas et al.   GENES & DEVELOPMENT

Masters of Longevity: Lessons from Long-Lived Bivalves – A Mini-Review

(2009) Eva E.R. Philipp et al.   GERONTOLOGY

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

(2009) Ana M Cervera et al.   Molecular Cancer

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus

(2009) M. Saito et al.   OSTEOPOROSIS INTERNATIONAL

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence

(2009) Hanane Agherbi et al.   PLoS One

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree

(2008) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression

(2008) Susanne Rohrbach et al.   BIOGERONTOLOGY

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

(2008) Lindsey A. Baker et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)

(2008) B. M. Emerling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE

Ageing and the regulation of protein synthesis: a balancing act?

(2008) Nektarios Tavernarakis   TRENDS IN CELL BIOLOGY