Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

(2014) Rakesh K. Pathak et al.   ACS Chemical Biology

Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder

(2014) Rafael T de Sousa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Behavioral extremes of trait anxiety in mice are characterized by distinct metabolic profiles

(2014) Michaela D. Filiou et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria

(2013) Reid H. J. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Targeting mitochondria: Strategies, innovations and challenges

(2013) Marvin Edeas et al.   MITOCHONDRION

Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model

(2012) Michaela D. Filiou et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates

(2012) Christian Webhofer et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach

(2012) Ahmad Ghanizadeh et al.   MITOCHONDRION

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Associations between Purine Metabolites and Clinical Symptoms in Schizophrenia

(2012) Jeffrey K. Yao et al.   PLoS One

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior

(2012) A Sah et al.   Translational Psychiatry

Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode

(2012) R Belzeaux et al.   Translational Psychiatry

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

Proteomics and Metabolomics Analysis of a Trait Anxiety Mouse Model Reveals Divergent Mitochondrial Pathways

(2011) Michaela D. Filiou et al.   BIOLOGICAL PSYCHIATRY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Profiling of mouse synaptosome proteome and phosphoproteome by IEF

(2010) Michaela D. Filiou et al.   ELECTROPHORESIS

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

A mouse model of anxiety molecularly characterized by altered protein networks in the brain proteome

(2009) Éva M. Szegő et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

(2009) Sergio Rodriguez-Cuenca et al.   FREE RADICAL BIOLOGY AND MEDICINE

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH

A Hypomorphic Vasopressin Allele Prevents Anxiety-Related Behavior

(2009) Mirjam Bunck et al.   PLoS One

Stable Isotope Metabolic Labeling with a Novel 15N-Enriched Bacteria Diet for Improved Proteomic Analyses of Mouse Models for Psychopathologies

(2009) Elisabeth Frank et al.   PLoS One

A MS data search method for improved15N-labeled protein identification

(2009) Yaoyang Zhang et al.   PROTEOMICS

How Prevalent Are Anxiety Disorders in Schizophrenia? A Meta-Analysis and Critical Review on a Significant Association

(2009) A. M. Achim et al.   SCHIZOPHRENIA BULLETIN

Evidence that oxidative stress is linked to anxiety-related behaviour in mice

(2008) Hassan Rammal et al.   BRAIN BEHAVIOR AND IMMUNITY

QuantiSpec — Quantitative mass spectrometry data analysis of 15N-metabolically labeled proteins

(2008) Katrin Haegler et al.   Journal of Proteomics

Mutant mice with reduced NMDA-NR1 glycine affinity or lack of d-amino acid oxidase function exhibit altered anxiety-like behaviors

(2008) Viviane Labrie et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR