Mitochondria and Trypanosomatids: Targets and Drugs

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

(2011) Louise M. Hughes et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

(2010) L. Carvalho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment

(2010) D. d. G. J. Batista et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

(2010) Mariana Boiani et al.   BIOCHEMICAL PHARMACOLOGY

Stage specific developmental changes in the mitochondrial and surface membrane associated redox systems of Leishmania donovani promastigote and amastigote

(2010) B. Chakraborty et al.   BIOCHEMISTRY-MOSCOW

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

(2010) J. Román Luque-Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence

(2010) Ranadhir Dey et al.   MOLECULAR MICROBIOLOGY

Effect of Crotalus viridis viridis snake venom on the ultrastructure and intracellular survival of Trypanosoma cruzi

(2010) CAMILA M. ADADE et al.   PARASITOLOGY

In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea

(2010) P. VEIGA-SANTOS et al.   PARASITOLOGY

Furazolidone is a selective in vitro candidate against Leishmania (L.) chagasi: an ultrastructural study

(2010) Juliana Quero Reimão et al.   PARASITOLOGY RESEARCH

Diverse Effects on Mitochondrial and Nuclear Functions Elicited by Drugs and Genetic Knockdowns in Bloodstream Stage Trypanosoma brucei

(2010) Christal Worthen et al.   PLoS Neglected Tropical Diseases

Berberine chloride causes a caspase-independent, apoptotic-like death inLeishmania donovanipromastigotes

(2009) Piu Saha et al.   FREE RADICAL RESEARCH

Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida)

(2009) Wanderley de Souza et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pro-apoptotic effect of the landrace Bangla Mahoba of Piper betle on Leishmania donovani may be due to the high content of eugenol

(2009) P. Misra et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates againstTrypanosomaandLeishmania

(2009) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

(2009) Suman K. Vodnala et al.   PLoS Neglected Tropical Diseases

An Introduction to the Structural Organization of Parasitic Protozoa

(2008) Wanderley Souza   CURRENT PHARMACEUTICAL DESIGN

Kinetoplast as a Potential Chemotherapeutic Target of Trypanosomatids

(2008) Maria Machado Motta   CURRENT PHARMACEUTICAL DESIGN

Mitochondrion of Protozoan Parasite Emerges as Potent Therapeutic Target:Exciting Drugs are on the Horizon

(2008) Nilkantha Sen et al.   CURRENT PHARMACEUTICAL DESIGN

Structural and Functional Association ofTrypanosoma bruceiMIX Protein with CytochromecOxidase Complex

(2008) Alena Zíková et al.   EUKARYOTIC CELL

Recent initiatives and strategies to developing new drugs for tropical parasitic diseases

(2008) Conor R Caffrey et al.   Expert Opinion on Drug Discovery

Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei

(2008) Jennifer L. Guler et al.   MOLECULAR MICROBIOLOGY

Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3'-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani

(2008) A. Roy et al.   MOLECULAR PHARMACOLOGY

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY

Leishmania mitochondrial tRNA importers

(2007) Samit Adhya   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY