Novel inhibitors of the Plasmodium falciparum electron transport chain

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochromebc1Complex

(2012) Cindy Vallières et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1

(2012) José M Bueno et al.   Future Medicinal Chemistry

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc 1 Catalytic Turnover and Protein Expression

(2012) Nicholas Fisher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases

(2012) Paul T. P. Bedingfield et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Suet C. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase

(2012) Alka Marwaha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)

(2012) Chandrakala Pidathala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

(2012) Yiqun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The global pipeline of new medicines for the control and elimination of malaria

(2012) Melinda P Anthony et al.   MALARIA JOURNAL

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

(2012) G. A. Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Chemical Genomic Analysis of Decoquinate, aPlasmodium falciparumCytochromebInhibitor

(2011) Tae-gyu Nam et al.   ACS Chemical Biology

Conformationally linked interaction in the cytochrome bc1 complex between inhibitors of the Qo site and the Rieske iron–sulfur protein

(2011) Edward A. Berry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Potent antimalarial 4-pyridones with improved physico-chemical properties

(2011) José M. Bueno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

Optimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure–Activity and Structure–Property Relationships

(2011) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity in Mice

(2011) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of the Mitochondrial Electron Transport Chain and de novo Pyrimidine Biosynthesis as Antimalarials: The Present Status

(2010) T. Rodrigues et al.   CURRENT MEDICINAL CHEMISTRY

Inhibiting Plasmodium cytochrome bc1: a complex issue

(2010) Victoria Barton et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

(2010) Michael L. Booker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current Trends in Ligand-Based Virtual Screening: Molecular Representations, Data Mining Methods, New Application Areas, and Performance Evaluation

(2010) Hanna Geppert et al.   Journal of Chemical Information and Modeling

Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

(2010) R. Matthew Cross et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2R null Mice Engrafted with Human Erythrocytes

(2009) M. B. Jimenez-Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

(2009) Xiaoyi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human andPlasmodium falciparumDihydroorotate Dehydrogenases†

(2009) Matthew Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

(2009) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of dual function acridones as a new antimalarial chemotype

(2009) Jane X. Kelly et al.   NATURE

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Flavin Oxidation and Electron-Transfer Inhibition inPlasmodium falciparumDihydroorotate Dehydrogenase†

(2008) Nicholas A. Malmquist et al.   BIOCHEMISTRY

Identification and Characterization of Small Molecule Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase

(2008) Vishal Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY