The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

(2010) D. P. Jones et al.   MOLECULAR INTERVENTIONS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury

(2010) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Nonprescription Use of Pain Relievers by Middle-Aged and Elderly Community-Living Adults: National Survey on Drug Use and Health

(2009) Dan G. Blazer et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Caspase activation is associated with spontaneous recovery from acute liver failure

(2008) Xandra Volkmann et al.   HEPATOLOGY