A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Towards real-time monitoring of artemisinin resistance

(2015) Didier Menard et al.   LANCET INFECTIOUS DISEASES

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

(2014) F. Joel Leong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

(2014) Kelli L. Kuhen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroResistance Selections forPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

(2014) Leila S. Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

(2014) Xiaoyi Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spiroindolone KAE609 for Falciparum and Vivax Malaria

(2014) Nicholas J. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel inhibitors of the Plasmodium falciparum electron transport chain

(2014) P. A. STOCKS et al.   PARASITOLOGY

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium

(2014) María Belén Jiménez-Díaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs

(2013) Michael J. Delves et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage ParasitesIn Vitro

(2013) Anne-Marie Zeeman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

(2013) Sandra March et al.   Cell Host & Microbe

Safety evaluation of leflunomide in rheumatoid arthritis

(2013) Helen I Keen et al.   Expert Opinion On Drug Safety

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

(2013) Sarah D'Alessandro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The changing epidemiology of malaria elimination: new strategies for new challenges

(2013) Chris Cotter et al.   LANCET

Malaria

(2013) Nicholas J White et al.   LANCET

Single-dose radical cure of Plasmodium vivax : a step closer

(2013) Ric N Price et al.   LANCET

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

Identification of inhibitors of Plasmodium falciparum gametocyte development

(2013) Sandra Duffy et al.   MALARIA JOURNAL

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Antimalarial drug discovery – the path towards eradication

(2013) JEREMY N BURROWS et al.   PARASITOLOGY

Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity

(2013) R. Rochford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

(2013) A. Nilsen et al.   Science Translational Medicine

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

(2013) Jennifer L. Guler et al.   PLoS Pathogens

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

(2012) Michael J. Delves et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The global pipeline of new medicines for the control and elimination of malaria

(2012) Melinda P Anthony et al.   MALARIA JOURNAL

A framework for assessing the risk of resistance for anti-malarials in development

(2012) Xavier C Ding et al.   MALARIA JOURNAL

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

(2012) Laura M. Sanz et al.   PLoS One

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

(2012) Y. Yuthavong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal dose finding for novel antimalarial combination therapy*

(2012) S. Duparc et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

(2012) Michael Delves et al.   PLOS MEDICINE

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

(2011) Eric H. Ekland et al.   FASEB JOURNAL

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity in Mice

(2011) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

(2011) Laurent Dembele et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The use of Cav rather than AUC in safety assessment

(2010) D.A. Smith et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2R null Mice Engrafted with Human Erythrocytes

(2009) M. B. Jimenez-Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

(2009) Xiaoyi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Flavin Oxidation and Electron-Transfer Inhibition inPlasmodium falciparumDihydroorotate Dehydrogenase†

(2008) Nicholas A. Malmquist et al.   BIOCHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH