Pharmacological approaches to restore mitochondrial function

RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice

(2016) Ravindar R. Thomas et al.   Aging-US

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

(2013) Allyn T. Londregan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

(2013) S. Chae et al.   Science Signaling

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

(2012) Danling Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

(2012) Pénélope A. Andreux et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

(2012) Cecile Vernochet et al.   Cell Metabolism

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Thiazolidinedione safety

(2012) Jacqueline Kung et al.   Expert Opinion On Drug Safety

Dietary obesity-associated Hif1  activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

(2012) J. Krishnan et al.   GENES & DEVELOPMENT

Mitochondrial Gene Therapy Improves Respiration, Biogenesis, and Transcription in G11778A Leber's Hereditary Optic Neuropathy and T8993G Leigh's Syndrome Cells

(2012) Shilpa Iyer et al.   HUMAN GENE THERAPY

Orphan Nuclear Receptor Estrogen-Related Receptor γ (ERRγ) Is Key Regulator of Hepatic Gluconeogenesis

(2012) Don-Kyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the therapeutic space around NAD+

(2012) Riekelt H. Houtkooper et al.   JOURNAL OF CELL BIOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

(2012) Toshimori Kitami et al.   PLoS One

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Clinical trials of resveratrol

(2011) Ketan R. Patel et al.   Annals of the New York Academy of Sciences

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet-Induced Hepatic Steatosis

(2011) C. Poussin et al.   DIABETES

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

(2011) Raymond J. Patch et al.   JOURNAL OF MEDICINAL CHEMISTRY

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

E2F transcription factor-1 regulates oxidative metabolism

(2011) Emilie Blanchet et al.   NATURE CELL BIOLOGY

A yeast-based assay identifies drugs active against human mitochondrial disorders

(2011) E. Couplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice

(2010) Outi M. Hyyti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

(2010) Craig C. Beeson et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5

(2010) Mark R. Herbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine

(2010) Laura L. Lackner et al.   CHEMISTRY & BIOLOGY

Long-Term Follow-Up of Bezafibrate Treatment in Patients With the Myopathic Form of Carnitine Palmitoyltransferase 2 Deficiency

(2010) J P Bonnefont et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

High mitochondrial DNA copy number has detrimental effects in mice

(2010) Emil Ylikallio et al.   HUMAN MOLECULAR GENETICS

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1

(2010) Mei Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

(2010) E H Jeninga et al.   ONCOGENE

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress

(2009) Natascia Ventura et al.   AGING CELL

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

(2009) H. Hwang et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins

(2009) Blanche Guillon et al.   FEBS Journal

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid Hormone-Related Regulation of Gene Expression in Human Fatty Liver

(2009) Jussi Pihlajamäki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficient Discovery of Selective Small Molecule Agonists of Estrogen-Related Receptor γ using Combinatorial Approach

(2009) Yongju Kim et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Mitochondrial medicine: entering the era of treatment

(2009) S. Koene et al.   JOURNAL OF INTERNAL MEDICINE

Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators

(2009) Chi B. Vu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

(2009) Karen A. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors

(2009) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes¶

(2009) Cédric Genet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression

(2009) Shilpa Iyer et al.   MITOCHONDRION

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of a Novel Small Molecule Subtype Specific Estrogen-Related Receptor α Antagonist in MCF-7 Breast Cancer Cells

(2009) Michael J. Chisamore et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Morphometric Changes Induced by Amino Acid Supplementation in Skeletal and Cardiac Muscles of Old Mice

(2008) Giovanni Corsetti et al.   AMERICAN JOURNAL OF CARDIOLOGY

Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity

(2008) Linda Mustelin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

(2008) Jean E. Bemis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

(2008) Daniel Moreno et al.   FEBS LETTERS

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Large-scale chemical dissection of mitochondrial function

(2008) Bridget K Wagner et al.   NATURE BIOTECHNOLOGY

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients

(2008) Toshinari Takamura et al.   Obesity

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1 

(2008) A. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA