Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis

(2018) Andrew E. Arrant et al.   JOURNAL OF NEUROSCIENCE

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

(2018) Yingxiao Shi et al.   NATURE MEDICINE

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation

(2018) Chiara Vidoni et al.   NEUROCHEMISTRY INTERNATIONAL

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases

(2018) Natura Myeku et al.   TRENDS IN MOLECULAR MEDICINE

Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease

(2018) Igor V. Kurochkin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking

(2017) Jane Fraser et al.   Essays in Biochemistry

Molecular control of chaperone-mediated autophagy

(2017) Steve Catarino et al.   Essays in Biochemistry

Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   HUMAN MOLECULAR GENETICS

Proteostasis disturbance in amyotrophic lateral sclerosis

(2017) Danilo B. Medinas et al.   HUMAN MOLECULAR GENETICS

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

(2017) Gisele S. Seixas da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons

(2017) Monica Boselli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

(2017) Ching-Hsiang Fan et al.   JOURNAL OF CONTROLLED RELEASE

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

(2017) Andrew P. Crew et al.   JOURNAL OF MEDICINAL CHEMISTRY

A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

(2017) Ryan P. Wurz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

(2017) Stefanie A.H. de Poot et al.   JOURNAL OF MOLECULAR BIOLOGY

The Journey of the Autophagosome through Mammalian Cell Organelles and Membranes

(2017) Diana Molino et al.   JOURNAL OF MOLECULAR BIOLOGY

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9

(2017) Simona Federica Spampinato et al.   JOURNAL OF NEUROCHEMISTRY

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

(2017) Zhong-Hao Zhang et al.   JOURNAL OF NEUROSCIENCE

A role for autophagy in long-term spatial memory formation in male rodents

(2017) Michael J. Hylin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson’s Disease

(2017) Rosalba Siracusa et al.   MOLECULAR NEUROBIOLOGY

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Polyglutamine tracts regulate beclin 1-dependent autophagy

(2017) Avraham Ashkenazi et al.   NATURE

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

Emptying the stores: lysosomal diseases and therapeutic strategies

(2017) Frances M. Platt   NATURE REVIEWS DRUG DISCOVERY

Zeroing in on neurodegenerative α-synuclein

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The brain, sirtuins, and ageing

(2017) Akiko Satoh et al.   NATURE REVIEWS NEUROSCIENCE

Progranulin, lysosomal regulation and neurodegenerative disease

(2017) Aimee W. Kao et al.   NATURE REVIEWS NEUROSCIENCE

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteolysis, synaptic plasticity and memory

(2017) Ashok N. Hegde   NEUROBIOLOGY OF LEARNING AND MEMORY

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

(2017) Kathleen M. Schoch et al.   NEURON

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease

(2017) Elma Aflaki et al.   NEURON

Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways

(2017) Naoki Yamamoto et al.   NEUROSCIENCE

Retinal biomarkers provide “insight” into cortical pharmacology and disease

(2017) Christine T.O. Nguyen et al.   PHARMACOLOGY & THERAPEUTICS

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models

(2017) S. Pablo Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review

(2017) Mark J. Millan   PROGRESS IN NEUROBIOLOGY

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease

(2017) Zhong-Can Chen et al.   Science Signaling

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage

(2017) Yi Yang et al.   Cell Death & Disease

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Reversible phosphorylation of the 26S proteasome

(2017) Xing Guo et al.   Protein & Cell

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease

(2017) Zhong-Can Chen et al.   Science Signaling

Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand

(2017) Nandini Ramesh et al.   Frontiers in Molecular Neuroscience

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation

(2017) Patricia Martín-Maestro et al.   Frontiers in Molecular Neuroscience

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

(2017) Rachel E. Lackie et al.   Frontiers in Neuroscience

The Enigmatic Role of C9ORF72 in Autophagy

(2017) Melissa Nassif et al.   Frontiers in Neuroscience

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers

(2017) Shi-Yu Yang et al.   Stem Cell Reports

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

(2017) Marta Pajares et al.   Redox Biology

Neprilysin Activity in Cerebrospinal Fluid is Associated with Dementia and Amyloid-β42 Levels in Lewy Body Disease

(2017) Walter Maetzler et al.   JOURNAL OF ALZHEIMERS DISEASE

Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease

(2017) Jackalina M. Van Kampen et al.   PLoS One

Proteasome impairment by α-synuclein

(2017) Lisa Zondler et al.   PLoS One

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

(2017) Tibor Kovács et al.   Scientific Reports

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

(2017) Dallan McMahon et al.   Scientific Reports

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

(2017) Alexandre Henriques et al.   Scientific Reports

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Impaired protein degradation in FTLD and related disorders

(2016) Julia K. Götzl et al.   AGEING RESEARCH REVIEWS

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin

(2016) Jose Felix Moruno-Manchon et al.   Aging-US

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

(2016) Min Shi et al.   Alzheimers & Dementia

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

(2016) Anna Migdalska-Richards et al.   ANNALS OF NEUROLOGY

The Proteasome and Oxidative Stress in Alzheimer's Disease

(2016) Vicent Bonet-Costa et al.   ANTIOXIDANTS & REDOX SIGNALING

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis

(2016) Jin Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

(2016) Tomohiro Umeda et al.   BRAIN

Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease

(2016) Akihiko Hoshi et al.   BRAIN PATHOLOGY

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

(2016) B. Mollereau et al.   BRAIN RESEARCH

Mechanisms of neuronal homeostasis: Autophagy in the axon

(2016) Sandra Maday   BRAIN RESEARCH

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

(2016) Masaki Ueno et al.   Brain Tumor Pathology

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Regulation of actin nucleation and autophagosome formation

(2016) Amanda S. Coutts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isolation and Characterization of RNA Aptamers against a Proteasome-Associated Deubiquitylating Enzyme UCH37

(2016) Jung Hoon Lee et al.   CHEMBIOCHEM

Nrf1 can be processed and activated in a proteasome-independent manner

(2016) Janakiram R. Vangala et al.   CURRENT BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

(2016) Zhentao Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages

(2016) Wen-Jun Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy

(2016) Francesco Panza et al.   Immunotherapy

Bioenergetic Impairment in Animal and Cellular Models of Alzheimer’s Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions

(2016) Sara Martire et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

Phospholipids in Autophagosome Formation and Fusion

(2016) Sascha Martens et al.   JOURNAL OF MOLECULAR BIOLOGY

Calpastatin inhibits motor neuron death and increases survival of hSOD1G93Amice

(2016) Mala V. Rao et al.   JOURNAL OF NEUROCHEMISTRY

A New Glucocerebrosidase Chaperone Reduces  -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

(2016) E. Aflaki et al.   JOURNAL OF NEUROSCIENCE

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes

(2016) Zheng Wang et al.   MOLECULAR CELL

RBD and Neurodegenerative Diseases

(2016) Haiyang Jiang et al.   MOLECULAR NEUROBIOLOGY

Inhibitory RNA Aptamers of Tau Oligomerization and Their Neuroprotective Roles against Proteotoxic Stress

(2016) Ji Hyeon Kim et al.   MOLECULAR PHARMACEUTICS

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism

(2016) B Wang et al.   MOLECULAR PSYCHIATRY

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

An evolutionarily conserved pathway controls proteasome homeostasis

(2016) Adrien Rousseau et al.   NATURE

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Resveratrol Attenuates Aβ25–35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway

(2016) Haoyue Deng et al.   NEUROCHEMICAL RESEARCH

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

(2016) Carolin Walter et al.   NEUROPHARMACOLOGY

Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington’s disease YAC128 mice

(2016) J. Jeon et al.   NEUROSCIENCE

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

(2016) Alexandre Carpentier et al.   Science Translational Medicine

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

(2016) Carla F. Bento et al.   Nature Communications

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

(2016) Pingping Song et al.   Protein & Cell

Role of Chaperone-Mediated Autophagy Dysfunctions in the Pathogenesis of Parkinson’s Disease

(2016) Gessica Sala et al.   Frontiers in Molecular Neuroscience

Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

(2016) So Youn Park et al.   PLoS One

Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

(2016) Isabel Onofre et al.   Scientific Reports

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

(2016) Alvaro Sanchez-Martinez et al.   Scientific Reports

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

Chemogenomic Profiling of Endogenous PARK2 Expression Using a Genome-Edited Coincidence Reporter

(2015) Samuel A. Hasson et al.   ACS Chemical Biology

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

(2015) Jose Manuel Bravo-San Pedro et al.   Autophagy

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

(2015) Huiqing Wang et al.   BRAIN PATHOLOGY

Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer׳s disease

(2015) Shin Bi Oh et al.   BRAIN RESEARCH

Primary cilia and autophagic dysfunction in Huntington’s disease

(2015) M Kaliszewski et al.   CELL DEATH AND DIFFERENTIATION

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

New Zebrafish Models of Neurodegeneration

(2015) Rebeca Martín-Jiménez et al.   Current Neurology and Neuroscience Reports

Differential autophagic responses to nano-sized materials

(2015) Lauren Popp et al.   CURRENT OPINION IN BIOTECHNOLOGY

Regulation of Histone Acetylation by Autophagy in Parkinson Disease

(2015) Goonho Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice

(2015) Angela W. Corona et al.   Journal of Neuroimmune Pharmacology

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease

(2015) Carmen Noelker et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

(2015) Marjana Brkic et al.   MEDIATORS OF INFLAMMATION

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

(2015) Yi-Sheng Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases

(2015) Maria Xilouri et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Beclin-1 Deficiency Alters Autophagosome Formation, Lysosome Biogenesis and Enhances Neuronal Vulnerability of HT22 Hippocampal Cells

(2015) J. Fekadu et al.   MOLECULAR NEUROBIOLOGY

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP/mutant presenilin-1–transfected Chinese hamster ovary cells

(2015) Bo-Ra Seo et al.   NEUROBIOLOGY OF AGING

Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

(2015) Kalpita Banerjee et al.   NEUROCHEMICAL RESEARCH

Biochemical protective effect of 1,25-dihydroxyvitamin D3 through autophagy induction in the MPTP mouse model of Parkinson’s disease

(2015) Huan Li et al.   NEUROREPORT

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein

(2015) Kiri Kilpatrick et al.   PLoS One

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

(2015) Wuyang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential sensitivity of immature and mature ventral mesencephalic neurons to rotenone induced neurotoxicity in vitro

(2015) V. Satish Bollimpelli et al.   TOXICOLOGY IN VITRO

Exercise Pills: At the Starting Line

(2015) Shunchang Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

(2015) Ibrahim González-Marrero et al.   Frontiers in Cellular Neuroscience

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

(2015) Jung Hoon Lee et al.   Scientific Reports

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

(2015) Soline Aubry et al.   PLoS One

Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

(2015) Kateri J. Spinelli et al.   PLoS One

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

(2014) Aaron H Burstein et al.   BMC Neurology

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

(2014) Lu-Shiun Her et al.   BRAIN PATHOLOGY

Spermidine protects against α-synuclein neurotoxicity

(2014) Sabrina Büttner et al.   CELL CYCLE

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

(2014) F M Menzies et al.   CELL DEATH AND DIFFERENTIATION

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

(2014) Daniel A. East et al.   CHEMISTRY & BIOLOGY

NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons

(2014) M.-F. Wu et al.   FREE RADICAL RESEARCH

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice

(2014) Chen Wenqiang et al.   HUMAN MOLECULAR GENETICS

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease

(2014) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Hydroxypropyl-β-cyclodextrin Promotes Transcription Factor EB-mediated Activation of Autophagy

(2014) Wensi Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

(2014) M. V. Rao et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

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