Autophagy modulation as a potential therapeutic target for diverse diseases

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

(2016) Sean M. Armour et al.   Aging-US

Targeting Autophagy Addiction in Cancer

(2015) Joseph D. Mancias et al.   Oncotarget

Ras-Related Tumorigenesis Is Suppressed by BNIP3-Mediated Autophagy through Inhibition of Cell Proliferation

(2015) Shan-Ying Wu et al.   NEOPLASIA

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

α-synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology

(2012) Silvia Corrochano et al.   Autophagy

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Pancreatic Acinar Cell-Specific Autophagy Disruption Reduces Coxsackievirus Replication and Pathogenesis In Vivo

(2012) Mehrdad Alirezaei et al.   Cell Host & Microbe

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

(2012) Tregei Starr et al.   Cell Host & Microbe

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy—alias self-eating—appetite and ageing

(2012) David C. Rubinsztein   EMBO REPORTS

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Chikungunya virus–induced autophagy delays caspase-dependent cell death

(2012) Pierre-Emmanuel Joubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

(2012) Y. Sun et al.   Science Signaling

Vitamin D Inhibits Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis Infection in Macrophages through the Induction of Autophagy

(2012) Grant R. Campbell et al.   PLoS Pathogens

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Beclin 1 or not Beclin 1...

(2011) Tassula Proikas-Cezanne et al.   Autophagy

Involvement of mitophagy in oncogenic K-Ras-induced transformation

(2011) June-Hyung Kim et al.   Autophagy

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

The Parkinson disease protein α-synuclein inhibits autophagy

(2011) Ashley R. Winslow et al.   Autophagy

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

(2011) Seon-Jin Lee et al.   Autophagy

Vitamin D and cancer: a review of molecular mechanisms

(2011) James C. Fleet et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Autophagy in Brain Tumors: A New Target for Therapeutic Intervention

(2011) Niroop Kaza et al.   BRAIN PATHOLOGY

Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer

(2011) Yaara Gorzalczany et al.   CANCER LETTERS

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

(2011) Vojo Deretic   CURRENT OPINION IN IMMUNOLOGY

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases

(2011) P. Zarogoulidis et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Genome profiling of pancreatic adenocarcinoma

(2011) David J. Birnbaum et al.   GENES CHROMOSOMES & CANCER

Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

(2011) Jia-Jia Huang et al.   HUMAN PATHOLOGY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hormonally Active Vitamin D3 (1α,25-Dihydroxycholecalciferol) Triggers Autophagy in Human Macrophages That Inhibits HIV-1 Infection

(2011) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

(2011) M. Renna et al.   JOURNAL OF CELL SCIENCE

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcipotriol Induces Autophagy in HeLa Cells and Keratinocytes

(2011) Richard C. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice

(2011) Y. Tian et al.   JOURNAL OF VIROLOGY

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

(2011) J. Li et al.   JOURNAL OF VIROLOGY

The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1

(2011) M. Chaumorcel et al.   JOURNAL OF VIROLOGY

Preventive therapy for breast cancer: a consensus statement

(2011) Jack Cuzick et al.   LANCET ONCOLOGY

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

(2011) B. Nyfeler et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway

(2011) Asad M. Taherbhoy et al.   MOLECULAR CELL

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7

(2011) Nobuo N. Noda et al.   MOLECULAR CELL

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy

(2011) Joung Hyuck Joo et al.   MOLECULAR CELL

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

(2011) S Shen et al.   ONCOGENE

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma

(2011) Hyun-Soo Kim et al.   PATHOLOGY RESEARCH AND PRACTICE

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

SMURF1 Amplification Promotes Invasiveness in Pancreatic Cancer

(2011) Kevin A. Kwei et al.   PLoS One

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagy and Cancer

(2011) L. Y. Mah et al.   Cold Spring Harbor Perspectives in Biology

Oncosuppressive Functions of Autophagy

(2010) Eugenia Morselli et al.   ANTIOXIDANTS & REDOX SIGNALING

A reporter cell system to monitor autophagy based on p62/SQSTM1

(2010) Kenneth Bowitz Larsen et al.   Autophagy

How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection

(2010) Nicolas Dupont et al.   BIOLOGY OF THE CELL

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex

(2010) X. Li et al.   CANCER RESEARCH

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

(2010) Dhiraj Kumar et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Autophagy: A Potential Link between Obesity and Insulin Resistance

(2010) Patrice Codogno et al.   Cell Metabolism

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Unconventional secretion ofPichia pastorisAcb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

(2010) Ravi Manjithaya et al.   JOURNAL OF CELL BIOLOGY

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

(2010) Muriel Mari et al.   JOURNAL OF CELL BIOLOGY

Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis

(2010) Charles R. Esther et al.   Journal of Cystic Fibrosis

Membrane Delivery to the Yeast Autophagosome from the Golgi–Endosomal System

(2010) Yohei Ohashi et al.   MOLECULAR BIOLOGY OF THE CELL

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy and innate immunity: Triggering, targeting and tuning

(2010) Rhea Sumpter et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

(2010) Shuqiu Zheng et al.   PLoS Genetics

The prognostic role of Beclin 1 protein expression in high-grade gliomas

(2009) Luigi Pirtoli et al.   Autophagy

The expression ofbeclin 1is associated with favorable prognosis in stage IIIB colon cancers

(2009) Bao-Xiu Li et al.   Autophagy

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Selective types of autophagy in yeast

(2009) Claudine Kraft et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity

(2009) D. J. Harriss et al.   Colorectal Disease

Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity

(2009) S. Wilkinson et al.   GENES & DEVELOPMENT

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Multicenter Study of Prevalence of Nontuberculous Mycobacteria in Patients with Cystic Fibrosis in France

(2009) A.-L. Roux et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk

(2009) S. R. Cummings et al.   JNCI-Journal of the National Cancer Institute

Interaction of ICP34.5 with Beclin 1 Modulates Herpes Simplex Virus Type 1 Pathogenesis through Control of CD4+ T-Cell Responses

(2009) D. A. Leib et al.   JOURNAL OF VIROLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

(2009) Luc English et al.   NATURE IMMUNOLOGY

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Beclin-1 Expression is a Predictor of Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma and Correlated to Hypoxia-Inducible Factor (HIF)-1α Expression

(2009) Yongshun Chen et al.   PATHOLOGY & ONCOLOGY RESEARCH

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

(2009) Christopher D. Intemann et al.   PLoS Pathogens

Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68

(2009) Xiaofei E et al.   PLoS Pathogens

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma

(2008) Z.-B. Ding et al.   CANCER RESEARCH

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

(2008) Y. Li et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Spinocerebellar ataxias caused by polyglutamine expansions: A review of therapeutic strategies

(2008) Benjamin R. Underwood et al.   CEREBELLUM

Structural basis of target recognition by Atg8/LC3 during selective autophagy

(2008) Nobuo N. Noda et al.   GENES TO CELLS

ARF Induces Autophagy by Virtue of Interaction with Bcl-xl

(2008) Julia Pimkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D3 Induces Autophagy of Human Myeloid Leukemia Cells

(2008) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC