Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

Brain and Plasma Riluzole Pharmacokinetics: Effect of Minocycline Combination

(2016) Aline Milane et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Models for predicting blood–brain barrier permeation

(2011) Peter Aadal Nielsen et al.   DRUG DISCOVERY TODAY

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Challenges to the development of disease-modifying therapies in Parkinson’s disease

(2011) A. H. V. Schapira   EUROPEAN JOURNAL OF NEUROLOGY

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

(2011) Andreia Teixeira-Castro et al.   HUMAN MOLECULAR GENETICS

A Compact β Model of huntingtin Toxicity

(2011) Qi Charles Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytotoxic and Apoptosis-Inducing Activities of Limonoids from the Seeds ofAzadirachta indica(Neem)

(2011) Takashi Kikuchi et al.   JOURNAL OF NATURAL PRODUCTS

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation

(2011) Toyohide Shinkawa et al.   MOLECULAR BIOLOGY OF THE CELL

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster

(2011) H. Hans Salamanca et al.   NUCLEIC ACIDS RESEARCH

Whole-Genome Analysis Reveals That Active Heat Shock Factor Binding Sites Are Mostly Associated with Non-Heat Shock Genes in Drosophila melanogaster

(2011) Sarah E. Gonsalves et al.   PLoS One

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

(2011) Liliana Batista-Nascimento et al.   PLoS One

Rescuing neurons in prion disease

(2010) Nicholas C. Verity et al.   BIOCHEMICAL JOURNAL

Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins

(2010) Ferdinando Fiumara et al.   CELL

ITZ-1, a Client-Selective Hsp90 Inhibitor, Efficiently Induces Heat Shock Factor 1 Activation

(2010) Haruhide Kimura et al.   CHEMISTRY & BIOLOGY

The Development of New Therapeutics for Alzheimer's Disease

(2010) M D Carter et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)

(2010) Sifeng Wang et al.   DRUG AND CHEMICAL TOXICOLOGY

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

(2010) Naoki Hayashida et al.   EMBO JOURNAL

Neuroprotective Drug Riluzole Amplifies the Heat Shock Factor 1 (HSF1)- and Glutamate Transporter 1 (GLT1)-dependent Cytoprotective Mechanisms for Neuronal Survival

(2010) Alice Y. C. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

(2010) J E Lancet et al.   LEUKEMIA

Resveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions

(2010) F. Zhang et al.   MOLECULAR PHARMACOLOGY

Bridging the Valley of Death of therapeutics for neurodegeneration

(2010) Steven Finkbeiner   NATURE MEDICINE

Hope builds for earlier detection of Alzheimer's disease

(2010) Alisa Opar   NATURE REVIEWS DRUG DISCOVERY

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70

(2010) Soumyajit Banerjee Mustafi et al.   PLoS One

Protein Kinase A Binds and Activates Heat Shock Factor 1

(2010) Ayesha Murshid et al.   PLoS One

Discovery and characterization of a mammalian amyloid disaggregation activity

(2010) Amber N. Murray et al.   PROTEIN SCIENCE

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

(2010) Daniel W. Neef et al.   PLOS BIOLOGY

Alzheimer's disease drug development and the problem of the blood-brain barrier

(2009) William M. Pardridge   Alzheimers & Dementia

Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury

(2009) Bin Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chloro-oxime derivatives as novel small molecule chaperone amplifiers

(2009) Yuefen Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers

(2009) Yuefen Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Pharmacological Targeting of the Hsp70 Chaperone

(2009) Srikanth Patury et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Arimoclomol: a potential therapy under development for ALS

(2009) Veena Lanka et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Heat Shock Protein 90: Inhibitors in Clinical Trials

(2009) Marco A. Biamonte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuki Nanke et al.   Modern Rheumatology

Heterotrimerization of Heat-Shock Factors 1 and 2 Provides a Transcriptional Switch in Response to Distinct Stimuli

(2009) Anton Sandqvist et al.   MOLECULAR BIOLOGY OF THE CELL

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

(2009) M Brunet Simioni et al.   ONCOGENE

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study

(2008) Gilbert Bensimon et al.   BRAIN

Neuroprotective Effects of Resveratrol on MPTP-Induced Neuron Loss Mediated by Free Radical Scavenging

(2008) Kwok-Tung Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships

(2008) Gary E. L. Brandt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

(2008) Bernadett Kalmar et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule

(2008) Amy Trott et al.   MOLECULAR BIOLOGY OF THE CELL

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis

(2008) Merit E. Cudkowicz et al.   MUSCLE & NERVE

Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection

(2008) Jingxian Yang et al.   PLoS One

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE