Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

Cerebrospinal Fluid Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Combination with Subcortical and Cortical Biomarkers in Vascular Dementia and Alzheimer's Disease

(2018) Maria Bjerke et al.   JOURNAL OF ALZHEIMERS DISEASE

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Plasma inflammatory biomarkers for Huntington’s disease patients and mouse model

(2015) Kuo-Hsuan Chang et al.   BRAIN BEHAVIOR AND IMMUNITY

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

(2015) Delphine Demeestere et al.   DRUG DISCOVERY TODAY

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

(2015) Fabian D Liechti et al.   Journal of Neuroinflammation

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala

(2015) Tomasz Gorkiewicz et al.   Frontiers in Cellular Neuroscience

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism

(2014) V. Annese et al.   Brain Structure & Function

A new angle on blood-CNS interfaces: A role for connexins?

(2014) Marijke De Bock et al.   FEBS LETTERS

Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis

(2014) Fabian D. Liechti et al.   INFECTION AND IMMUNITY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

(2014) Manuel A. Friese et al.   Nature Reviews Neurology

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

(2014) Artem Kaplan et al.   NEURON

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinases and Their Multiple Roles in Alzheimer’s Disease

(2014) Xiang-Xiang Wang et al.   Biomed Research International

The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

(2013) Helen Könnecke et al.   Clinical & Developmental Immunology

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple sclerosis is primarily a neurodegenerative disease

(2013) Abhijit Chaudhuri   JOURNAL OF NEURAL TRANSMISSION

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases

(2013) Anika Langenfurth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

(2013) R E Vandenbroucke et al.   Mucosal Immunology

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Association Studies of MMP-9 in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

(2013) Xianghua He et al.   PLoS One

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke

(2013) Shaheen E. Lakhan et al.   Frontiers in Neurology

Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview

(2012) Vincenzo Pizza et al.   CNS & Neurological Disorders-Drug Targets

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Molecular Pathology in Neurodegenerative Diseases

(2012) Alexander H. Peden et al.   CURRENT DRUG TARGETS

On the ‘classification’ of neurodegenerative disorders: discrete entities, overlap or continuum?

(2012) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

MMP9: A novel function in synaptic plasticity

(2012) Magdalena Dziembowska et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-Derived IL-1  Regulates the Production of GM-CSF by CD4+ T Cells and    T Cells

(2012) J. R. Lukens et al.   JOURNAL OF IMMUNOLOGY

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood-CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

(2012) R. E. Vandenbroucke et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Synaptic circuit remodelling by matrix metalloproteinases in health and disease

(2012) George W. Huntley   NATURE REVIEWS NEUROSCIENCE

Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brain

(2012) Yang Liu et al.   NEUROBIOLOGY OF AGING

Amyotrophic lateral sclerosis: A neurovascular disease

(2011) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Regulation of matrix metalloproteinase 2 by oligomeric amyloid β protein

(2011) Wenjun Li et al.   BRAIN RESEARCH

The Interaction of Amyloid β and the Receptor for Advanced Glycation Endproducts Induces Matrix Metalloproteinase-2 Expression in Brain Endothelial Cells

(2011) Huan Du et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

(2011) Evelin L. Schaeffer et al.   Clinics

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

(2011) R. E. Vandenbroucke et al.   EUROPEAN RESPIRATORY JOURNAL

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

(2011) Kazunori Miyazaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice

(2011) Cheol Hong Park et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Natural History of Multiple Sclerosis: Early Prognostic Factors

(2011) Ellen M. Mowry   NEUROLOGIC CLINICS

Alzheimer's disease: β-amyloid plaque formation in human brain

(2011) Philip Seeman et al.   SYNAPSE

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Long-Term Expression of Tissue-Inhibitor of Matrix Metalloproteinase-1 in the Murine Central Nervous System Does Not Alter the Morphological and Behavioral Phenotype but Alleviates the Course of Experimental Allergic Encephalomyelitis

(2010) Gioia E.M. Althoff et al.   AMERICAN JOURNAL OF PATHOLOGY

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Biological role of matrix metalloproteinases: a critical balance

(2010) S. Loffek et al.   EUROPEAN RESPIRATORY JOURNAL

Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease

(2010) Solveig Horstmann et al.   INTERNATIONAL PSYCHOGERIATRICS

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice

(2010) Cynthia P.W. Soon et al.   NEUROMUSCULAR DISORDERS

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

(2010) John P. Miller et al.   NEURON

Role of matrix metalloproteinase-9 (MMP-9) in striatal blood-brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease

(2010) J. Duran-Vilaregut et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat

(2010) S. Walsh et al.   NEUROSCIENCE

Multiple brain pathologies in dementia are common

(2010) M. Woodward et al.   European Geriatric Medicine

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

(2009) Sang-Kyu Park et al.   AGING CELL

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2009) I. Niebroj-Dobosz et al.   EUROPEAN JOURNAL OF NEUROLOGY

Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

(2009) Feng Chen et al.   HEPATOLOGY

Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathyin vivoin transgenic mice

(2009) Monica Garcia-Alloza et al.   JOURNAL OF NEUROCHEMISTRY

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin  1 Signaling

(2009) P. Michaluk et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloprotease-9 Inhibition Improves Amyloid  -Mediated Cognitive Impairment and Neurotoxicity in Mice

(2009) H. Mizoguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)

(2009) Lubin Fang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Association of matrix metalloproteinases with MRI indices of brain ischemia and aging

(2009) José Rafael Romero et al.   NEUROBIOLOGY OF AGING

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

(2009) J. S. Henkel et al.   NEUROLOGY

Distinct neuroinflammatory profile in post-mortem human Huntingtonʼs disease

(2009) Aurelio Silvestroni et al.   NEUROREPORT

Matrix metalloproteinases-2 and -3 are reduced in cerebrospinal fluid with low beta-amyloid1–42 levels

(2009) Reinhilde Mlekusch et al.   NEUROSCIENCE LETTERS

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Neuroinflammation in the living brain of Parkinson's disease

(2009) Yasuomi Ouchi et al.   PARKINSONISM & RELATED DISORDERS

Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?

(2008) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

(2008) M. C. Pott Godoy et al.   BRAIN

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

(2008) Johannes Levin et al.   EXPERIMENTAL NEUROLOGY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells

(2008) Dong Hee Choi et al.   JOURNAL OF NEUROCHEMISTRY

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

(2008) Jose A. Obeso et al.   MOVEMENT DISORDERS

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING