Protein kinase C controls lysosome biogenesis independently of mTORC1

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

(2015) C. Stretton et al.   BIOCHEMICAL JOURNAL

Beyond indigestion: emerging roles for lysosome-based signaling in human disease

(2015) Shawn M Ferguson   CURRENT OPINION IN CELL BIOLOGY

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

(2015) Benoît Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

(2015) Wuyang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

(2014) Pitchai Balakumar et al.   CELLULAR SIGNALLING

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Lysosomal Adaptation: How the Lysosome Responds to External Cues

(2014) C. Settembre et al.   Cold Spring Harbor Perspectives in Biology

Protein kinase C pharmacology: refining the toolbox

(2013) Alyssa X. Wu-zhang et al.   BIOCHEMICAL JOURNAL

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

(2013) Carmine Spampanato et al.   EMBO Molecular Medicine

A RANKL-PKC -TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

(2013) M. Ferron et al.   GENES & DEVELOPMENT

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

(2013) Santosh Chauhan et al.   MOLECULAR CELL

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression

(2011) Weixiang Guo et al.   NEURON

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy

(2010) Shahab Shahnazari et al.   Cell Host & Microbe

GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection

(2010) Y. Xue et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY