Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 10, Pages 2699-2704
Publisher
Proceedings of the National Academy of Sciences
Online
2017-02-22
DOI
10.1073/pnas.1616152114
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
- (2016) Ganqiang Liu et al. ANNALS OF NEUROLOGY
- Survival and dementia inGBA-associated Parkinson's disease: The mutation matters
- (2016) Roberto Cilia et al. ANNALS OF NEUROLOGY
- Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
- (2016) Edward Rockenstein et al. HUMAN MOLECULAR GENETICS
- CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease
- (2016) John Marshall et al. MOLECULAR THERAPY
- Glucocerebrosidase in Parkinson's disease: Insights into pathogenesis and prospects for treatment
- (2016) Anthony H.V. Schapira et al. MOVEMENT DISORDERS
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
- (2016) Céline Galvagnion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial
- (2015) Timothy M Cox et al. LANCET
- No evidence for substrate accumulation in Parkinson brains withGBAmutations
- (2015) Matthew E. Gegg et al. MOVEMENT DISORDERS
- Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
- (2015) Céline Galvagnion et al. Nature Chemical Biology
- Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease
- (2015) Tomoko Oeda et al. NEUROBIOLOGY OF AGING
- Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
- (2015) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle
- (2015) S. Pablo Sardi et al. PROGRESS IN NEUROBIOLOGY
- Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
- (2014) Ianai Fishbein et al. BRAIN
- GBA-associated Parkinson's disease: Reduced survival and more rapid progression in a prospective longitudinal study
- (2014) Kathrin Brockmann et al. MOVEMENT DISORDERS
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Glucocerebrosidase mutations and the pathogenesis of Parkinson disease
- (2013) Michelle S. Beavan et al. ANNALS OF MEDICINE
- Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort
- (2013) Sophie E. Winder-Rhodes et al. BRAIN
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
- (2013) S. Pablo Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
- (2013) Michael A. Nalls et al. JAMA Neurology
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
- (2012) Nunilo Cremades et al. CELL
- -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
- (2012) D. Scott et al. JOURNAL OF NEUROSCIENCE
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- Lysosome-dependent pathways as a unifying theme in Parkinson's disease
- (2012) George K. Tofaris MOVEMENT DISORDERS
- Cognitive performance of GBA mutation carriers with early-onset PD: The CORE-PD study
- (2012) R. N. Alcalay et al. NEUROLOGY
- Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease
- (2012) Mario A. Cabrera-Salazar et al. PLoS One
- Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing
- (2011) Valerie Cullen et al. ANNALS OF NEUROLOGY
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models
- (2011) Y.H. Xu et al. MOLECULAR GENETICS AND METABOLISM
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism
- (2009) Amy B. Manning-Boğ et al. NEUROTOXICOLOGY
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now