Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

(2014) Maria Xilouri et al.   Autophagy

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

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Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

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Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

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Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Mitochondrial Inhibitor Models of Huntington’s Disease and Parkinson’s Disease Induce Zinc Accumulation and Are Attenuated by Inhibition of Zinc Neurotoxicity in vitro or in vivo

(2012) Christian T. Sheline et al.   Neurodegenerative Diseases

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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(2011) Michael G. Palmgren et al.   Annual Review of Biophysics

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(2011) Claire M. Weekley et al.   BIOCHEMISTRY

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

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(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

Microautophagy of Cytosolic Proteins by Late Endosomes

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Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

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Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein

(2011) Jieqiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

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EBV-gp350 Confers B-Cell Tropism to Tailored Exosomes and Is a Neo-Antigen in Normal and Malignant B Cells—A New Option for the Treatment of B-CLL

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Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

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Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

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Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells

(2010) Elizabeth A. Carter et al.   Molecular BioSystems

Prion-like transmission of protein aggregates in neurodegenerative diseases

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Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes

(2009) Rui Zhan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein knockdown attenuates MPP+ induced mitochondrial dysfunction of SH-SY5Y cells

(2009) Fengxia Wu et al.   BRAIN RESEARCH

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc

(2009) Sook-Jeong Lee et al.   GLIA

Inducible over-expression of wild type α-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

(2009) Kostas Vekrellis et al.   JOURNAL OF NEUROCHEMISTRY

The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of β-amyloid peptide

(2009) Michael King et al.   JOURNAL OF NEUROSCIENCE RESEARCH

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems

(2009) Jade B. Aitken et al.   RADIATION PHYSICS AND CHEMISTRY

Zinc and cortical plasticity

(2008) Amy S. Nakashima et al.   BRAIN RESEARCH REVIEWS

Autophagy and multivesicular bodies: two closely related partners

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Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes

(2008) Yvonne Ng et al.   Cell Metabolism

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

(2007) Wolfgang Maret   EXPERIMENTAL GERONTOLOGY