Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

(2013) Eleni N. Tsakiri et al.   FASEB JOURNAL

Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster

(2012) Åsa Fredriksson et al.   AGING CELL

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein Oxidative Modification in the Aging Organism and the Role of the Ubiquitin Proteasomal System

(2012) Marc Kastle et al.   CURRENT PHARMACEUTICAL DESIGN

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Selective autophagy in the maintenance of cellular homeostasis in aging organisms

(2011) Vanessa M. Hubbard et al.   BIOGERONTOLOGY

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

(2011) Y. X. Zhu et al.   BLOOD

Cellular stress response pathways and ageing: intricate molecular relationships

(2011) Nikos Kourtis et al.   EMBO JOURNAL

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

(2011) Undine Kruegel et al.   PLoS Genetics

Carbonylated proteins are eliminated during reproduction in C. elegans

(2010) Jérôme Goudeau et al.   AGING CELL

Biomarkers of aging in Drosophila

(2010) Jake Jacobson et al.   AGING CELL

Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy

(2010) Lawrence R. Dick et al.   DRUG DISCOVERY TODAY

Functional Interplay between Mitochondrial and Proteasome Activity in Skin Aging

(2010) Rafał Kozieł et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

(2010) K. B. Grimberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The 26 S Proteasome: From Basic Mechanisms to Drug Targeting

(2009) Ami Navon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

Insights into the molecular architecture of the 26S proteasome

(2009) S. Nickell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

(2008) Nicolle Breusing et al.   BIOLOGICAL CHEMISTRY

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY