Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

(2016) Aude Marzo et al.   CURRENT BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

(2015) Zhi-Min Long et al.   CNS Neuroscience & Therapeutics

Maslinic acid promotes synaptogenesis and axon growth via Akt/GSK-3β activation in cerebral ischemia model

(2015) Yisong Qian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CREB expression mediates amyloid β-induced basal BDNF downregulation

(2015) Elyse Rosa et al.   NEUROBIOLOGY OF AGING

GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease

(2015) Mélissa Côté et al.   NEUROBIOLOGY OF DISEASE

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

(2014) S Sakura Minami et al.   NATURE MEDICINE

Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

(2014) Jackalina M. Van Kampen et al.   PLoS One

Activity-dependent secretion of progranulin from synapses

(2013) E. Petoukhov et al.   JOURNAL OF CELL SCIENCE

Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

(2013) Oscar Seira et al.   MOLECULAR NEUROBIOLOGY

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

Progranulin regulates neuronal outgrowth independent of Sortilin

(2012) Jennifer Gass et al.   Molecular Neurodegeneration

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Wnt Signaling Enhances Neurogenesis and Improves Neurological Function after Focal Ischemic Injury

(2012) Adi Shruster et al.   PLoS One

Wnt signaling in development and disease

(2012) Yingzi Yang   Cell and Bioscience

Neuroprotective effects of progranulin in ischemic mice

(2011) Jiang Tao et al.   BRAIN RESEARCH

Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses

(2011) L. Tapia et al.   JOURNAL OF NEUROSCIENCE

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

(2011) Jindong Xu et al.   NEUROBIOLOGY OF AGING

Synaptic dysfunction in progranulin-deficient mice

(2011) Terri L. Petkau et al.   NEUROBIOLOGY OF DISEASE

Functional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency, Implicating Wnt Signaling

(2011) Ezra Y. Rosen et al.   NEURON

Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway

(2011) Hyun Yi et al.   NEUROREPORT

Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation

(2011) T. Nedachi et al.   NEUROSCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation

(2011) Rong Qin et al.   TOXICOLOGY LETTERS

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

(2010) Zeshan Ahmed et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer Disease–like Phenotype Associated With the c.154delA Mutation in Progranulin

(2010) Brendan J. Kelley et al.   ARCHIVES OF NEUROLOGY

The role of Wnt signaling in neuroprotection

(2010) W. Cerpa et al.   DRUG NEWS & PERSPECTIVES

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways

(2010) Kyoung Ah Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures

(2010) Gernot Kleinberger et al.   JOURNAL OF NEUROCHEMISTRY

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β

(2010) Xue Gao et al.   Protein & Cell

Inflammation in transgenic mouse models of neurodegenerative disorders

(2009) Claudia Schwab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models

(2009) Sandra Pereson et al.   JOURNAL OF PATHOLOGY

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

(2009) R. Kimura et al.   NEUROSCIENCE

Association Between Progranulin and β-Amyloid in Dementia With Lewy Bodies

(2008) Gonzalo J. Revuelta et al.   American Journal of Alzheimers Disease and Other Dementias

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

Progranulin (PGRN) expression in ALS: An immunohistochemical study

(2008) D. Irwin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease

(2008) N. Brouwers et al.   NEUROLOGY