The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

Phenolic contents, cellular antioxidant activity and antiproliferative capacity of different varieties of oats

(2018) Chao Chen et al.   FOOD CHEMISTRY

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

(2017) David Porras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

(2017) Rejina Afrin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma

(2017) Honglei Jiang et al.   International Journal of Biological Sciences

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics

(2017) Lucía Méndez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo

(2017) Yuan Yan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

(2017) Feng Gao et al.   ONCOLOGY REPORTS

Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

(2017) Hongtan Wu et al.   Oxidative Medicine and Cellular Longevity

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

(2017) Xin Yang et al.   PHARMACEUTICAL BIOLOGY

Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis

(2017) Yun Chen et al.   PHARMACEUTICAL BIOLOGY

New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

(2017) María Eugenia Inzaugarat et al.   PLoS One

Dihydromyricetin Reduces TGF-β Via P53 Activation-dependent Mechanism in Hepatocellular Carcinoma HepG2 Cells

(2017) Xiaojie Huang et al.   PROTEIN AND PEPTIDE LETTERS

Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liver

(2017) Mihaela Zaulet et al.   Experimental and Therapeutic Medicine

Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition

(2017) Ling Gao et al.   Drug Design Development and Therapy

Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet

(2017) Dongxiao Su et al.   Food & Function

3-Decylcatechol induces autophagy-mediated cell death through the IRE1α/JNK/p62 in hepatocellular carcinoma cells

(2017) Da-Hye Go et al.   Oncotarget

A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells

(2017) Di Wang et al.   Scientific Reports

Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy

(2017) Danielle Gonçalves et al.   Food & Nutrition Research

The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways

(2017) Mаhmoud Youns et al.   PLoS One

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

(2017) Daniel F. Hicks et al.   Scientific Reports

Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy

(2017) Zhigang Liu et al.   Scientific Reports

Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice

(2016) Qian Sun et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling

(2016) Wenhui Zhong et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines

(2016) Li Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle

(2016) Ziyou Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats

(2016) Yang Cheng et al.   Chinese Journal of Integrative Medicine

Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

(2016) Haitao Shi et al.   CLINICAL NUTRITION

Phytochemical profiles and antioxidant activity of 27 cultivars of tea

(2016) Liang Zeng et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF-κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling

(2016) Xiaodong Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Chrysin, Abundant in Morinda citrifolia Fruit Water–EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells

(2016) Cheng Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway

(2016) Xing Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

(2016) Sven M. Francque et al.   JOURNAL OF HEPATOLOGY

Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance

(2016) Lulu Wang et al.   JOURNAL OF LIPID RESEARCH

Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways

(2016) Subhayan Sur et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities

(2016) Yu-Bo Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

(2016) Zhenxing He et al.   Molecular Medicine Reports

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching

(2016) Chu-Sook Kim et al.   Nutrition Research and Practice

Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway

(2016) Huanhuan Chen et al.   ONCOLOGY REPORTS

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

(2016) Sha Li et al.   Oxidative Medicine and Cellular Longevity

Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells

(2016) Liwei He et al.   PHARMACEUTICAL BIOLOGY

Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis

(2016) M. L. Arffa et al.   PLoS One

Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice

(2016) Subhayan Sur et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Theaflavins suppress tumor growth and metastasis via the blockage of the STAT3 pathway in hepatocellular carcinoma

(2016) Jianping Shao et al.   OncoTargets and Therapy

EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells

(2016) Xinsheng Cheng et al.   Oncology Letters

Isolation and evaluation of biological efficacy of quercetol in human hepatic carcinoma cells

(2016) Huma Ali et al.   Drug Design Development and Therapy

Dietary Natural Products for Prevention and Treatment of Liver Cancer

(2016) Yue Zhou et al.   Nutrients

(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

(2016) Tiemin Pei et al.   Oncotarget

Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway

(2016) Zhen Wang et al.   Oncotarget

Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase

(2016) Xinhua Song et al.   Oncotarget

Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway

(2016) Enxiang Zhang et al.   Scientific Reports

Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-κB Signaling

(2016) Liwen Wang et al.   Biomed Research International

The Role of Iron and Iron Overload in Chronic Liver Disease

(2016) Sandra Milic et al.   MEDICAL SCIENCE MONITOR

Phenolics profile and anti-proliferative activity of Cyphomandra Betacea fruit in breast and liver cancer cells

(2016) Maisarah Abdul Mutalib et al.   SpringerPlus

Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets

(2016) Ángela Rojas et al.   Scientific Reports

The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

(2015) Dong-ke Yu et al.   ACTA PHARMACOLOGICA SINICA

Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases

(2015) Yuan Yan et al.   ANTI-CANCER DRUGS

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

(2015) Robert Domitrović et al.   ARCHIVES OF TOXICOLOGY

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

(2015) Zhiguo Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Determine the structure of phosphorylated modification of icariin and its antiviral activity against duck hepatitis virus A

(2015) Wen Xiong et al.   BMC Veterinary Research

Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells

(2015) Shang-Tao Chien et al.   Cancer Cell International

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

(2015) Cornel Balta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

(2015) Hung-Rong Yen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The potential of flavonoids in the treatment of non-alcoholic fatty liver disease

(2015) Bregje Van De Wier et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Antiviral Natural Products Against Chronic Hepatitis B: Recent Developments

(2015) Mohammad K. Parvez et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   DIGESTIVE AND LIVER DISEASE

Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis

(2015) Qichao Wang et al.   DIGESTIVE DISEASES AND SCIENCES

AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor

(2015) Eun Hye Jung et al.   EUROPEAN JOURNAL OF NUTRITION

Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-κB signaling pathway in H22 tumor-bearing mice

(2015) Fangfang Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

(2015) Cheng Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

(2015) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase

(2015) Atsushi Furuta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

(2015) Ming Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome

(2015) Maddalena Parafati et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action

(2015) Noémie Calland et al.   JOURNAL OF VIROLOGY

Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner

(2015) Haruka Yamashita et al.   Marine Drugs

Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium

(2015) Jixiang Zhang et al.   MEDICAL ONCOLOGY

A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease

(2015) Pei-Wen Zhang et al.   MEDICINE

Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma

(2015) Soumya C. Iyer et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

(2015) Akhilendra Kumar Maurya et al.   MOLECULAR BIOLOGY REPORTS

Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways

(2015) HUI ZHANG et al.   Molecular Medicine Reports

Cocoa flavonoids protect hepatic cells against high-glucose-induced oxidative stress: Relevance of MAPKs

(2015) Isabel Cordero-Herrera et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alcoholic liver disease: mechanisms of injury and targeted treatment

(2015) Alexandre Louvet et al.   Nature Reviews Gastroenterology & Hepatology

Long-term supplementation with a low dose of proanthocyanidins normalized liver miR-33a and miR-122 levels in high-fat diet–induced obese rats

(2015) Laura Baselga-Escudero et al.   NUTRITION RESEARCH

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   PHARMACOLOGICAL RESEARCH

Baicalein Triggers Autophagy and Inhibits the Protein Kinase B/Mammalian Target of Rapamycin Pathway in Hepatocellular Carcinoma HepG2 Cells

(2015) Ya-Fang Wang et al.   PHYTOTHERAPY RESEARCH

A polymethoxy flavonoids-richCitrus aurantiumextract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model

(2015) Bong-Keun Choi et al.   PHYTOTHERAPY RESEARCH

Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma

(2015) Matthew A.C. Zapf et al.   SURGERY

Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

(2015) Ratana Banjerdpongchai et al.   TUMOR BIOLOGY

Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE−/− Mice through the ROS/MAPK/NF-κB Pathway

(2015) Zhe-Rong Xu et al.   Nutrients

Gallic Acid Induces Necroptosis via TNF–α Signaling Pathway in Activated Hepatic Stellate Cells

(2015) Ya Ju Chang et al.   PLoS One

Tannic Acid Inhibits Hepatitis C Virus Entry into Huh7.5 Cells

(2015) Shuanghu Liu et al.   PLoS One

(−)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes

(2014) Hsiu-Chen Huang et al.   ANTIVIRAL RESEARCH

Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase

(2014) You-Jin Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Puerarin Attenuates Carbon Tetrachloride-Induced Liver Oxidative Stress and Hyperlipidaemia in Mouse by JNK/c-Jun/CYP7A1 Pathway

(2014) Jie-Qiong Ma et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways

(2014) Yu-Jin Hwang et al.   BMB Reports

Resveratrol mitigate structural changes and hepatic stellate cell activation in N′-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage

(2014) Areeba Ahmad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

(2014) Veronique S. Chachay et al.   Clinical Gastroenterology and Hepatology

Therapeutic potential of morin against liver fibrosis in rats: Modulation of oxidative stress, cytokine production and nuclear factor kappa B

(2014) Gehan H. Heeba et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell

(2014) Jianwei Qiu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigallocatechin-3-gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non-cancerous liver cells

(2014) YUNJUAN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway

(2014) XIAOYUN SHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis

(2014) Yong Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Luteolin Alleviates Alcoholic Liver Disease Induced by Chronic and Binge Ethanol Feeding in Mice

(2014) Gaigai Liu et al.   JOURNAL OF NUTRITION

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways

(2014) Jie Li et al.   LIVER INTERNATIONAL

Anti-hepatitis C virus compounds obtained fromGlycyrrhiza uralensis and otherGlycyrrhizaspecies

(2014) Myrna Adianti et al.   MICROBIOLOGY AND IMMUNOLOGY

A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver

(2014) Lizbeth Jiménez-Flores et al.   MOLECULES

Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway

(2014) GUIHONG HUANG et al.   ONCOLOGY REPORTS

Nuclear Receptor-Mediated Alleviation of Alcoholic Fatty Liver by Polyphenols Contained in Alcoholic Beverages

(2014) Ruiqing Yao et al.   PLoS One

Luteoloside Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Inhibition of NLRP3 Inflammasome

(2014) Shao-hua Fan et al.   PLoS One

Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling

(2014) Guangwen Shu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels

(2014) Chikako Shibata et al.   VIROLOGY

Resources and Biological Activities of Natural Polyphenols

(2014) An-Na Li et al.   Nutrients

Autophagy and Non-Alcoholic Fatty Liver Disease

(2014) Vanessa J. Lavallard et al.   Biomed Research International

The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma

(2014) Rasha H. Hussein et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective

(2013) João Tomé-Carneiro et al.   Annals of the New York Academy of Sciences

Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells

(2013) A-Young Choi et al.   APOPTOSIS

High-Dose Resveratrol Treatment for 2 Weeks Inhibits Intestinal and Hepatic Lipoprotein Production in Overweight/Obese Men

(2013) Satya Dash et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway

(2013) Xing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone

(2013) Tae-Gue Ahn et al.   BIOCHEMICAL PHARMACOLOGY

Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse

(2013) Min-Cheol Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress

(2013) Lijuan Su et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants

(2013) Sha Li et al.   INDUSTRIAL CROPS AND PRODUCTS

Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study

(2013) RYUICHIRO SAKATA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: Partial mediation by the transcription factor NFAT1

(2013) Weiqi Dai et al.   MOLECULAR CARCINOGENESIS

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Green Tea Phenolic Epicatechins Inhibit Hepatitis C Virus Replication via Cycloxygenase-2 and Attenuate Virus-Induced Inflammation

(2013) Ying-Ting Lin et al.   PLoS One

Total phenolic contents and antioxidant capacities of 51 edible and wild flowers

(2013) An-Na Li et al.   Journal of Functional Foods

Protective Effects of Total Flavonoids from Litsea coreana on Alcoholic Fatty Liver in Rats Associated with Down-Regulation Adipose Differentiation-Related Protein Expression

(2012) Cheng-Mu Hu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

(2012) Jorge Joven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid

(2012) Yaoyao Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice

(2012) Dong-Wook Kim et al.   Biomolecules & Therapeutics

A Polyphenol Extract ofHibiscus sabdariffaL. Ameliorates Acetaminophen-Induced Hepatic Steatosis by Attenuating the Mitochondrial Dysfunctionin Vivoandin Vitro

(2012) Chao-Hsin LEE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus - insights into its mechanisms of action

(2012) B Stefanska   BRITISH JOURNAL OF PHARMACOLOGY

Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling

(2012) Meijuan Zou et al.   CELLULAR SIGNALLING

Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity

(2012) Jayant S. Londhe et al.   FITOTERAPIA

Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice

(2012) Shuai Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid

(2012) Yoon Mee Yang et al.   HEPATOLOGY

Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT

(2012) Min Xu et al.   HEPATOLOGY RESEARCH

Potential of Fruit Wastes as Natural Resources of Bioactive Compounds

(2012) Gui-Fang Deng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling

(2012) RONG-RUI LIANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways

(2012) Naoko Seki et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance

(2012) Luis Daniel Hernández-Ortega et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity

(2012) Joo-Won Lee et al.   JOURNAL OF LIPID RESEARCH

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells

(2012) Min Xu et al.   TOXICOLOGY LETTERS

Toxic hepatitis in occupational exposure to solvents

(2012) Giulia Malaguarnera   WORLD JOURNAL OF GASTROENTEROLOGY

Determination of antioxidant property and their lipophilic and hydrophilic phenolic contents in cereal grains

(2012) Gui-Fang Deng et al.   Journal of Functional Foods

Antioxidant capacities and total phenolic contents of 56 vegetables

(2012) Gui-Fang Deng et al.   Journal of Functional Foods

Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi

(2012) Ya-Jun Guo et al.   Food & Function

Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

(2011) Jeong Sook Noh et al.   BRITISH JOURNAL OF NUTRITION

Antioxidant capacities and total phenolic contents of 62 fruits

(2011) Li Fu et al.   FOOD CHEMISTRY

The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry

(2011) Sandra Ciesek et al.   HEPATOLOGY

(−)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry

(2011) Noémie Calland et al.   HEPATOLOGY

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

(2011) Jing Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rutin Inhibits Oleic Acid Induced Lipid Accumulation via Reducing Lipogenesis and Oxidative Stress in Hepatocarcinoma Cells

(2011) Cheng-Hsun Wu et al.   JOURNAL OF FOOD SCIENCE

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice

(2011) Tsuyoshi Goto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity

(2011) L. Bachmetov et al.   JOURNAL OF VIRAL HEPATITIS

Kaempferol Regulates the Lipid-Profile in High-Fat Diet-Fed Rats through an Increase in Hepatic PPARαLevels

(2011) Chia Chang et al.   PLANTA MEDICA

(−)-Epigallocatechin gallate inhibits hepatitis C virus (HCV) viral protein NS5B

(2011) Changhyun Roh et al.   TALANTA

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

(2010) Maya Mouler Rechtman et al.   FEBS LETTERS

Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer

(2010) Li   INTERNATIONAL JOURNAL OF ONCOLOGY

Tricetin, a Dietary Flavonoid, Induces Apoptosis through the Reactive Oxygen Species/c-Jun NH2-Terminal Kinase Pathway in Human Liver Cancer Cells

(2010) Ya-Ling Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2

(2010) Jianguo Lin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effect of epigallocatechin-3-gallate on iron overload in mice with alcoholic liver disease

(2010) Yuan Ren et al.   MOLECULAR BIOLOGY REPORTS

Antioxidant Capacities and Total Phenolic Contents of 56 Wild Fruits from South China

(2010) Li Fu et al.   MOLECULES

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα

(2010) Jonathan Goldwasser et al.   PLoS One

The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells

(2010) Kuo-Hua Lee et al.   TOXICOLOGY LETTERS

Galangin induces apoptosis of hepatocellular carcinoma cellsviathe mitochondrial pathway

(2010) Hai-Tao Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR

(2010) Svjetlana Medjakovic et al.   Nutrients

Morin regulates the expression of NF-κB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma

(2009) V. Sivaramakrishnan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

(2009) Abdelhakim Ahmed–Belkacem et al.   GASTROENTEROLOGY

EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells

(2008) Masahito Shimizu et al.   CANCER LETTERS

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Two flavonoids extracts fromGlycyrrhizae radixinhibitin vitrohepatitis C virus replication

(2008) Yuko Sekine-Osajima et al.   HEPATOLOGY RESEARCH

Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma

(2008) Sundaram Jagan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells

(2008) Ming-Hsien Yeh et al.   TOXICOLOGY LETTERS

Resveratrol inhibits tumor necrosis factor-α-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells

(2007) Haibo Yu et al.   BIOMEDICINE & PHARMACOTHERAPY