Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 78, Issue 6, Pages 1143-1150Publisher
SPRINGER
DOI: 10.1007/s00280-016-3171-y
Keywords
Eriocitrin; Hepatocellular carcinoma; Cell cycle arrest; Apoptosis
Categories
Funding
- National Natural Science Foundation of China [31170676, 81300398]
- Natural Science Foundation of Guangdong Province, China [2015A030313518]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2014-1685]
- Scientific Research Foundation for Returned Overseas Scholars of Guangdong Medical College, China [B2012082]
- Sail Plan the introduction of the Shortage of Top-Notch Talent Project [[2014] 1]
- Science and Technology Planning Project [2013B021800072]
- Education Discipline Construction Project of Guangdong Province, China [2013KJCX0090]
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Hepatocellular carcinoma is a lethal cancer with high recurrence ratio and lacks effective therapeutics. In the past few years, it has been reported that increased intake of vegetables and fruits could reduce the cancer incidence, which suggests dietary agents might possess anticancer effects. Eriocitrin is a flavonoid isolated from lemon, which is known as a strong antioxidant agent. We here for the first time demonstrated that eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Furthermore, we found that eriocitrin could trigger apoptosis by activating mitochondria-involved intrinsic signaling pathway. Thus, eriocitrin might be regarded as a potential chemopreventive natural product to inhibit the early malignant transformation of hepatocellular carcinoma.
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