The potential of flavonoids in the treatment of non-alcoholic fatty liver disease

Quercetin Decreases Liver Damage in Mice with Non-Alcoholic Steatohepatitis

(2013) Éder Marcolin et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Molecular mechanisms underlying the anti-obesity potential of prunetin, an O-methylated isoflavone

(2013) Tae-Gue Ahn et al.   BIOCHEMICAL PHARMACOLOGY

Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver

(2013) Jiayin Yao et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Rutin: therapeutic potential and recent advances in drug delivery

(2013) Shrestha Sharma et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production

(2013) Bregje van de Wier et al.   FEBS LETTERS

Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

(2013) Veerle Bieghs et al.   LIVER INTERNATIONAL

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis inApoE-deficient mice

(2013) Prakash Doddapattar et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rutin Suppresses Palmitic Acids-Triggered Inflammation in Macrophages and Blocks High Fat Diet-Induced Obesity and Fatty Liver in Mice

(2013) Mingming Gao et al.   PHARMACEUTICAL RESEARCH

The cocoa flavanol (−)-epicatechin protects the cortisol response

(2013) Erik J.B. Ruijters et al.   PHARMACOLOGICAL RESEARCH

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

(2013) Fatma Ucar et al.   REDOX REPORT

Ten misconceptions about antioxidants

(2013) Aalt Bast et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

(2013) Ignazio Grattagliano   WORLD JOURNAL OF GASTROENTEROLOGY

Time Course of the Development of Nonalcoholic Fatty Liver Disease in the Otsuka Long-Evans Tokushima Fatty Rat

(2013) Yi-Sun Song et al.   Gastroenterology Research and Practice

Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions?

(2012) Y. Yilmaz   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats

(2012) Renan Qin et al.   ARCHIVES OF PHARMACAL RESEARCH

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

(2012) Chin-Shiu Huang et al.   ARCHIVES OF TOXICOLOGY

Ombuin-3-O-β-d-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors α and δ/β

(2012) Mastura Abd Malek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid

(2012) Yaoyao Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Isoflavones: estrogenic activity, biological effect and bioavailability

(2012) Daniela Cristina Vitale et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils

(2012) Hua-Zhong Ying et al.   FOOD AND CHEMICAL TOXICOLOGY

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

(2012) Carmela Loguercio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription

(2012) Fuichi Yap et al.   International Journal of Biological Sciences

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

(2012) Zaijun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nonalcoholic Fatty Liver Disease

(2012) Stergios A. Polyzos et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity

(2012) Joo-Won Lee et al.   JOURNAL OF LIPID RESEARCH

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis1–3

(2012) Eder Marcolin et al.   JOURNAL OF NUTRITION

Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice

(2012) Young-Sil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Therapeutic potential of green tea in nonalcoholic fatty liver disease

(2012) Christopher Masterjohn et al.   NUTRITION REVIEWS

Absorption and metabolism of milk thistle flavanolignans in humans

(2012) Luca Calani et al.   PHYTOMEDICINE

Silibinin Regulates Gene Expression, Production and Secretion of Mucin from Cultured Airway Epithelial Cells

(2012) Kil-Dong Kim et al.   PHYTOTHERAPY RESEARCH

Quercetin Reduces High-Fat Diet-Induced Fat Accumulation in the Liver by Regulating Lipid Metabolism Genes

(2012) Chang Hwa Jung et al.   PHYTOTHERAPY RESEARCH

Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression

(2012) Gui-bo Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis

(2012) Federico Salamone et al.   Translational Research

Genetically modified mouse models for the study of nonalcoholic fatty liver disease

(2012) Perumal Nagarajan   WORLD JOURNAL OF GASTROENTEROLOGY

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

The flavonoid quercetin in disease prevention and therapy: Facts and fancies

(2011) Maria Russo et al.   BIOCHEMICAL PHARMACOLOGY

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity

(2011) A Crespillo et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of oxidative stress in non-alcoholic steatohepatitis

(2011) G.H. Koek et al.   CLINICA CHIMICA ACTA

Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis

(2011) Agnes W. Boots et al.   CLINICAL NUTRITION

Effects of Flavonoids and other Polyphenols on Inflammation

(2011) R. González et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Risks and benefits of dietary isoflavones for cancer

(2011) Susanne Andres et al.   CRITICAL REVIEWS IN TOXICOLOGY

Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis

(2011) Federico Salamone et al.   DIGESTIVE AND LIVER DISEASE

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

(2011) Ya-Chen Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP–PKA-dependent signaling pathway

(2011) Wei Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-alcoholic fatty liver disease: is iron relevant?

(2011) Julia O’Brien et al.   Hepatology International

Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms

(2011) Guiyuan Ji et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Green Tea Polyphenol (−)-Epigallocatechin-3-gallate on Newly Developed High-Fat/Western-Style Diet-Induced Obesity and Metabolic Syndrome in Mice

(2011) Yu-Kuo Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rutin Inhibits Oleic Acid Induced Lipid Accumulation via Reducing Lipogenesis and Oxidative Stress in Hepatocarcinoma Cells

(2011) Cheng-Hsun Wu et al.   JOURNAL OF FOOD SCIENCE

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

(2011) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis

(2011) Hea Jin Park et al.   JOURNAL OF NUTRITION

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

(2011) Min-Yu Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice

(2011) Tsuyoshi Goto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1

(2011) Honghui Guo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate–activated protein kinase in human HepG2 cells and obese mice

(2011) Yong Pil Hwang et al.   NUTRITION RESEARCH

Kaempferol Regulates the Lipid-Profile in High-Fat Diet-Fed Rats through an Increase in Hepatic PPARαLevels

(2011) Chia Chang et al.   PLANTA MEDICA

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Naringenin Decreases Progression of Atherosclerosis by Improving Dyslipidemia in High-Fat–Fed Low-Density Lipoprotein Receptor–Null Mice

(2010) Erin E. Mulvihill et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease

(2010) Mi-Hyun Kim et al.   BRITISH JOURNAL OF NUTRITION

Fruit polyphenols, immunity and inflammation

(2010) Javier González-Gallego et al.   BRITISH JOURNAL OF NUTRITION

A single NFκB system for both canonical and non-canonical signaling

(2010) Vincent Feng-Sheng Shih et al.   CELL RESEARCH

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Dietary naringenin increases hepatic peroxisome proliferators–activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats

(2010) Kae Won Cho et al.   EUROPEAN JOURNAL OF NUTRITION

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

(2010) M-H Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo

(2010) Nuria Mateo Anson et al.   JOURNAL OF NUTRITION

A Brief Historical Overview of the Past Two Decades of Soy and Isoflavone Research

(2010) Mark Messina   JOURNAL OF NUTRITION

Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

(2010) Hea Jin Park et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice

(2010) Masuko Kobori et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis

(2010) Christoph Dorn et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial

(2010) Serena A. Heinz et al.   PHARMACOLOGICAL RESEARCH

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα

(2010) Jonathan Goldwasser et al.   PLoS One

Progression from isolated steatosis to steatohepatitis and fibrosis in nonalcoholic fatty liver disease

(2010) R. Pais et al.   Clinics and Research in Hepatology and Gastroenterology

Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR

(2010) Svjetlana Medjakovic et al.   Nutrients

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

(2009) Hong-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways

(2009) Peiyong Zheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Rutin on Lipid Profile in Hypercholesterolaemic Rats

(2009) Amir Ziaee et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study

(2009) Sarah Egert et al.   BRITISH JOURNAL OF NUTRITION

Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

(2009) Giovanni E Mann et al.   CURRENT OPINION IN PHARMACOLOGY

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor-Null Mice With Diet-Induced Insulin Resistance

(2009) E. E. Mulvihill et al.   DIABETES

Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis

(2009) Yara Haddad et al.   Evidence-based Complementary and Alternative Medicine

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Luca Valenti et al.   GASTROENTEROLOGY

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue

(2009) Ueno   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Phenolic Compounds Rutin ando-Coumaric Acid Ameliorate Obesity Induced by High-Fat Diet in Rats

(2009) Chin-Lin Hsu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis

(2009) Kazuo Nakamoto et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling

(2009) Martin J. Ronis et al.   JOURNAL OF NUTRITION

Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis

(2009) Takahiro Kawasaki et al.   JOURNAL OF NUTRITION

A Silybin-Phospholipid Complex Prevents Mitochondrial Dysfunction in a Rodent Model of Nonalcoholic Steatohepatitis

(2009) G. Serviddio et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet

(2009) Nora Chen et al.   NUTRITION RESEARCH

Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance

(2009) Sumiyabanu MOHAMED SALIH et al.   Journal of Diabetes

The Key Importance of Soy Isoflavone Bioavailability to Understanding Health Benefits

(2008) Theresa Larkin et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Safety of Green Tea Extracts

(2008) Dandapantula N Sarma et al.   DRUG SAFETY

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nuclear factor- B inhibition and non-alcoholic steatohepatitis: inflammation as a target for therapy

(2008) F. Marra   GUT

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Drug–drug interactions of silymarin on the perspective of pharmacokinetics

(2008) Jhy-Wen Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Animal models of NASH: Getting both pathology and metabolic context right

(2008) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Daily Consumption of an Aqueous Green Tea Extract Supplement Does Not Impair Liver Function or Alter Cardiovascular Disease Risk Biomarkers in Healthy Men

(2008) Jan Frank et al.   JOURNAL OF NUTRITION

A casein diet added isoflavone-enriched soy protein favorably affects biomarkers of steatohepatitis in obese Zucker rats

(2008) Oddrun Anita Gudbrandsen et al.   NUTRITION

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

(2008) Eric R Kallwitz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet

(2007) Nalan Kuzu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY