Baicalein Triggers Autophagy and Inhibits the Protein Kinase B/Mammalian Target of Rapamycin Pathway in Hepatocellular Carcinoma HepG2 Cells

Synthesis and biological evaluation of baicalein derivatives as potent antitumor agents

(2014) Rong Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Anti-Bladder-Tumor Effect of Baicalein fromScutellaria baicalensisGeorgi and Its ApplicationIn Vivo

(2013) Jin-Yi Wu et al.   Evidence-based Complementary and Alternative Medicine

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-inflammatory Activity of Baicalein in LPS-Stimulated RAW264.7 Macrophages via Estrogen Receptor and NF-κB-Dependent Pathways

(2013) Guan-Wei Fan et al.   INFLAMMATION

The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib

(2013) Yiyu Zou et al.   Journal of Thoracic Oncology

Baicalein Inhibits the Invasion and Metastatic Capabilities of Hepatocellular Carcinoma Cells via Down-Regulation of the ERK Pathway

(2013) Kunlun Chen et al.   PLoS One

A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway

(2013) Xuenong Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Why is autophagy important in human diseases?

(2012) Kaipeng Jing et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells

(2012) Xiang Li et al.   International Journal of Biological Sciences

Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation

(2012) Ya-Hsin Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice

(2011) Lili Chen et al.   ANTIVIRAL RESEARCH

Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative–nitrosative stress and p38 MAPK activation

(2011) Roman Stavniichuk et al.   EXPERIMENTAL NEUROLOGY

Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses

(2011) Yen-Mei Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Mitochondria protection of baicalein against oxidative damage via induction of manganese superoxide dismutase

(2010) In Kyung Lee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways

(2010) Nameeta Mujumdar et al.   GASTROENTEROLOGY

Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism

(2010) Mali Jiang et al.   JOURNAL OF NEUROCHEMISTRY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

In vitro activity of baicalein against Candida albicans biofilms

(2008) YingYing Cao et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS