Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Letter
Oncology
Jun Zhang, Xilin He, Yajie Wan, Honghong Zhang, Tao Tang, Meng Zhang, Shiyi Yu, Weiyong Zhao, Liming Chen
Summary: CD44 is overexpressed in HCC and promotes proliferation and migration of HCC cells via oncogenic YAP, suggesting it may be a crucial axis in HCC pathogenesis.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Srishti Kotiyal, Kimberley Jane Evason
Summary: Mutations in TERT promoter and CTNNB1 gene are common in hepatocellular carcinoma (HCC), and their interaction plays a role in promoting hepatocarcinogenesis.
Article
Cell Biology
Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie, Dong Fang
Summary: This study reveals the immunosuppressive role of spermine in hepatocellular carcinoma by activating the CaSR pathway to promote the expression of PD-L1 and reducing the infiltration of CD8(+) T cells. This discovery highlights the crucial function of spermine in establishing immune privilege.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Cen-Shan Lin, Yuyi Liang, Shu-Guang Su, Yin-Li Zheng, Neng Jiang, Jing Zhou, Ying Zhang, Ru Deng, Chun-Hua Wang, Shi-Xun Lu, Yu-Hua Huang, Li-Li Liu, Chao Zhang, Jing-Ping Yun
Summary: The study identified elevated Nup93 expression in HCC tissues, especially in cases with metastasis, and its association with poorer prognosis. Nup93 was found to promote HCC metastasis and proliferation by regulating beta-catenin translocation, while the interaction between Nup93 and beta-catenin, as well as a positive feedback loop involving LEF1 and beta-catenin, further facilitated metastasis and proliferation in HCC. The findings suggest potential therapeutic targets in the LEF1-Nup93-beta-catenin pathway for HCC treatment.
Article
Cell Biology
Shuangqin Chen, Meijia Zhang, Jiemei Li, Jiewu Huang, Shan Zhou, Xiaotao Hou, Huiyun Ye, Xi Liu, Shaowei Xiang, Weiwei Shen, Jinhua Miao, Fan Fan Hou, Youhua Liu, Lili Zhou
Summary: The activation of beta-catenin in renal tubular cells leads to the release of exosomes containing osteopontin (OPN) that are then taken up by fibroblasts, promoting their proliferation and activation through binding with CD44. Deletion of beta-catenin or CD44 greatly improves renal fibrosis. N-terminal fragment of OPN is secreted into the urine and negatively correlated with kidney function in CKD patients. Urinary exosomes from CKD patients accelerate renal fibrosis, which can be blocked by CD44 deletion.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Fei-fei Pan, Yan-Biao Zheng, Chuan-Jian Shi, Feng-wei Zhang, Jin-fang Zhang, Wei-ming Fu
Summary: The research demonstrates that apigenin (API) can suppress tumor growth of hepatocellular carcinoma (HCC) by down-regulating the H19-mediated Wnt/beta-catenin signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang
Summary: CD58 is upregulated in HCC tissues and its overexpression is associated with poor prognosis in HCC patients. CD58 promotes proliferation and metastasis in HCC cells by activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 may serve as a prognostic biomarker and therapeutic target for HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Elaine da Silva Siqueira, Virginia Marcia Concato, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Idessania Nazareth Costa, Waldiceu Aparecido Verri Junior, Wander Rogerio Pavanelli, Carolina Panis, Mario Sergio Mantovani, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa
Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.
Article
Environmental Sciences
Rong Li, Runze Shang, Shunle Li, Yifan Ren, Lin Shen, Longbao Yang, Shuo Chen, Xi Chen, Junhui Li, Meng Xu
Summary: The study found that high expression of LOXL3 in HCC was significantly correlated with tumor size and clinical stage, predicting a poor prognosis. Experimental results demonstrated that LOXL3 promoted HCC EMT process through the Snail1/USP4-mediated circulation loop and Wnt/β-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Jialing Sun, Xuemei Yang, Haitao Sun, Shaohui Huang, Haiyan An, Wei Xu, Weicong Chen, Wenting Zhao, Chunyu He, Xiaodan Zhong, Tong Li, Yang Liu, Bin Wen, Qingfeng Du, Songqi He
Summary: Baicalin, derived from Scutellaria baicalensis Georgi, has been found to inhibit hepatocellular carcinoma (HCC) growth and metastasis. This study showed that Baicalin suppressed HCC cell proliferation, invasion, and metastasis, induced cell cycle arrest and apoptosis. In vivo experiments demonstrated that Baicalin inhibited HCC growth. Mechanistically, Baicalin inhibited the expressions of ROCK1, p-GSK-3β, and β-catenin, while up-regulating GSK-3β and p-β-catenin expressions. Baicalin also regulated the expressions of various proteins involved in HCC progression. Molecular docking studies revealed a binding interaction between Baicalin and ROCK1. Suppression of ROCK1 expression enhanced the inhibitory effects of Baicalin on HCC, while restoration of ROCK1 expression reduced Baicalin's efficacy. These findings suggest that Baicalin suppresses HCC proliferation and metastasis through the ROCK1/GSK-3β/β-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Jinrong Zhu, Yongqi Wu, Shaoxi Lao, Jianfei Shen, Yijian Yu, Chunqiang Fang, Na Zhang, Yan Li, Rongxin Zhang
Summary: The study shows that overexpression of TRIM54 is associated with HCC progression, promoting proliferation and metastasis; inhibiting TRIM54 can significantly suppress HCC development; Targeting the TRIM54/Axin1/beta-catenin signaling axis could be a promising therapeutic strategy for HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rongcai Yue, Haiping Liu, Yaxin Huang, Jing Wang, Dongmei Shi, Yanping Su, Yufei Luo, Ping Cai, Guilin Jin, Changxi Yu
Summary: Gelsemium elegans, a toxic plant used in traditional Chinese medicine, showed anti-tumor effects in hepatocellular carcinoma (HCC) through the alkaloid compound sempervirine which induced apoptosis, cell cycle arrest in G(1) phase, and inactivation of the Wnt/beta-catenin pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Debolina Pal, Subhayan Sur, Rituparna Roy, Suvra Mandal, Chinmay Kumar Panda
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Chemistry, Medicinal
Rituparna Roy, Debolina Pal, Subhayan Sur, Suvra Mandal, Prosenjit Saha, Chinmay Kumar Panda
PHYTOTHERAPY RESEARCH
(2019)
Article
Cell Biology
Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford, Ratna B. Ray
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Gastroenterology & Hepatology
Mustafa Nazzal, Subhayan Sur, Robert Steele, Mousumi Khatun, Tapas Patra, Nancy Phillips, John Long, Ranjit Ray, Ratna B. Ray
Review
Oncology
Subhayan Sur, Ratna B. Ray
Article
Biochemistry & Molecular Biology
Subhayan Sur, Hiroshi Nakanishi, Robert Steele, Dapeng Zhang, Mark A. Varvares, Ratna B. Ray
Article
Gastroenterology & Hepatology
Mousumi Khatun, Subhayan Sur, Robert Steele, Ranjit Ray, Ratna B. Ray
Summary: This study revealed that HCV exploits Linc-Pint in hepatocytes to enhance lipogenesis, shedding light on its role in virus replication and liver disease progression.
Review
Biochemistry & Molecular Biology
Subhayan Sur, Ratna B. Ray
Summary: Long non-coding RNAs (lncRNAs) have gained widespread attention as a new layer of regulation in biological processes since the beginning of the 21st century. They share many similarities with mRNAs and regulate biological processes by interacting with DNA, RNA, proteins, and miRNAs. ELDR is an important lncRNA involved in development and cancer, with its high expression and oncogenic potential being the focus of research.
Article
Biochemistry & Molecular Biology
Subhayan Sur, Mousumi Khatun, Robert Steele, T. Scott Isbell, Ranjit Ray, Ratna B. Ray
Summary: The study found high levels of TNC and FGB in exosomes from COVID-19 patients, which may trigger pro-inflammatory responses in distant organs through exosome transportation. This suggests a potential mechanism for tissue damage and cytokine storm in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Subhayan Sur, Robert Steele, T. Scott Isbell, Kalyan Nagulapalli Venkata, Mostafa E. Rateb, Ratna B. Ray
Summary: Head and neck cancer (HNC) is a highly aggressive cancer with limited treatment options. Momordicine-I (M-I), found in bitter melon extract, has shown significant potential in inhibiting HNC cell growth and tumor progression. M-I works by targeting c-Met and downstream signaling molecules, offering a promising alternative therapeutic approach for managing HNC.
Article
Biology
Debolina Pal, Subhayan Sur, Rituparna Roy, Suvra Mandal, Chinmay Kumar Panda
Summary: Amarogentin was found to prevent liver carcinogenesis at mild dysplastic stage by modulating cell cycle, apoptosis, and self-renewal pathways, with upregulation of cell cycle regulatory genes and hypomethylation observed in specific genes, suggesting epigenetic modulation as a mechanism of action.
JOURNAL OF BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Subhayan Sur, Robert Steele, Ben C. B. Ko, Jinsong Zhang, Ratna B. Ray
Summary: Long noncoding RNAs (lncRNAs) have been recognized as important regulators in biological processes. In this study, the lncRNA ELDR was found to play a potential role as an oncogene in oral cancers. ELDR enhances the expression of cell cycle-related genes, leading to G2/M progression. Additionally, ELDR stabilizes CTCF and upregulates Forkhead box M1, which induces Aurora kinase A expression. These findings provide mechanistic insights into the role of ELDR in the neoplastic transformation of normal keratinocytes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Microbiology
Subhayan Sur, Robert Steele, T. Scott Isbell, Ranjit Ray, Ratna B. Ray
Summary: This study demonstrates that exosomes from severe COVID-19 patients can enhance inflammasome activity in distant endothelial cells, leading to the secretion of IL-1 beta and inflammatory response.
Meeting Abstract
Oncology
Subhayan Sur, Robert Steele, Ratna B. Ray
Article
Gastroenterology & Hepatology
Reina Sasaki, Subhayan Sur, Qi Cheng, Robert Steele, Ratna B. Ray
HEPATOLOGY COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
