Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

Functionalized white graphene – Copper oxide nanocomposite: Synthesis, characterization and application as catalyst for thermal decomposition of ammonium perchlorate

(2017) Sanoop Paulose et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

3D cell technologies head to the R&D assembly line

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

(2017) Yun Xiao et al.   TISSUE ENGINEERING PART B-REVIEWS

Advances in Production and Applications of Carbon Nanotubes

(2017) Xilai Jia et al.   Topics in Current Chemistry

Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques

(2016) Yao Cheng et al.   ACS Applied Materials & Interfaces

Hybrid hydrogel-aligned carbon nanotube scaffolds to enhance cardiac differentiation of embryoid bodies

(2016) Samad Ahadian et al.   Acta Biomaterialia

Electrical and mechanical stimulation of cardiac cells and tissue constructs

(2016) Whitney L. Stoppel et al.   ADVANCED DRUG DELIVERY REVIEWS

Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues

(2016) Nicole T. Feric et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of integrins in mediating cardiac fibroblast–cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology

(2016) Robert A. Civitarese et al.   BASIC RESEARCH IN CARDIOLOGY

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

(2016) Seyed Ali Mousavi Shaegh et al.   Biomicrofluidics

Prevascularization in tissue engineering: Current concepts and future directions

(2016) Matthias W. Laschke et al.   BIOTECHNOLOGY ADVANCES

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Have microfluidics delivered for drug discovery?

(2016) Arvind Chandrasekaran et al.   Expert Opinion on Drug Discovery

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

(2016) Onur Kilic et al.   LAB ON A CHIP

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

3D cardiac μtissues within a microfluidic device with real-time contractile stress readout

(2016) Aereas Aung et al.   LAB ON A CHIP

Mini-pillar array for hydrogel-supported 3D culture and high-content histologic analysis of human tumor spheroids

(2016) Jihoon Kang et al.   LAB ON A CHIP

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

(2016) Jolien Robijns et al.   LASERS IN MEDICAL SCIENCE

Electrically conductive gold nanoparticle-chitosan thermosensitive hydrogels for cardiac tissue engineering

(2016) Payam Baei et al.   Materials Science & Engineering C-Materials for Biological Applications

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function

(2016) Ron Feiner et al.   NATURE MATERIALS

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Three-dimensional mapping and regulation of action potential propagation in nanoelectronics-innervated tissues

(2016) Xiaochuan Dai et al.   Nature Nanotechnology

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine

(2016) Elena Matsa et al.   PHYSIOLOGICAL REVIEWS

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disciplined approach to drug discovery and early development

(2016) Robert M. Plenge   Science Translational Medicine

Liver and kidney cells cultures in a new perfluoropolyether biochip

(2016) Rachid Jellali et al.   SENSORS AND ACTUATORS B-CHEMICAL

A versatile lab-on-a-chip tool for modeling biological barriers

(2016) Fruzsina R. Walter et al.   SENSORS AND ACTUATORS B-CHEMICAL

Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions

(2016) Hon Fai Chan et al.   Small

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Concise Review: Organ Engineering: Design, Technology, and Integration

(2016) Gaurav Kaushik et al.   STEM CELLS

Current Cell-Based Strategies for Whole Kidney Regeneration

(2016) Nafiseh Poornejad et al.   TISSUE ENGINEERING PART B-REVIEWS

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip

(2016) Yu-suke Torisawa et al.   TISSUE ENGINEERING PART C-METHODS

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

The Importance of Physiologically Relevant Cell Lines for Studying Virus–Host Interactions

(2016) David Hare et al.   Viruses-Basel

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment

(2016) Danh Truong et al.   Scientific Reports

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

(2016) Mengying Zhou et al.   Scientific Reports

Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

(2016) Mohammad Hossein Mohammadi et al.   Advanced Healthcare Materials

High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip

(2016) Xiangchen Che et al.   Micromachines

Microfluidic-Based Multi-Organ Platforms for Drug Discovery

(2016) Ahmad Rezaei Kolahchi et al.   Micromachines

Highly Elastic and Moldable Polyester Biomaterial for Cardiac Tissue Engineering Applications

(2016) Locke Davenport Huyer et al.   ACS Biomaterials-Science & Engineering

Highly Elastic and Moldable Polyester Biomaterial for Cardiac Tissue Engineering Applications

(2016) Locke Davenport Huyer et al.   ACS Biomaterials Science & Engineering

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces

(2016) Vinay V. Abhyankar et al.   PLoS One

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Microfluidic Multiculture Assay to Analyze Biomolecular Signaling in Angiogenesis

(2015) Ashleigh B. Theberge et al.   ANALYTICAL CHEMISTRY

Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption

(2015) Tohid F. Didar et al.   BIOMATERIALS

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

(2015) Kan Yue et al.   BIOMATERIALS

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model

(2015) Katelyn L. Sellgren et al.   Biomicrofluidics

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

(2015) Thibault Bricks et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Fluid and cell behaviors along a 3D printed alginate/gelatin/fibrin channel

(2015) Yufan Xu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications

(2015) Jun Xu et al.   Cell Stem Cell

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Organ-On-A-Chip: Development and Clinical Prospects Toward Toxicity Assessment with an Emphasis on Bone Marrow

(2015) Jeehye Kim et al.   DRUG SAFETY

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microfluidic devices for construction of contractile skeletal muscle microtissues

(2015) Kazunori Shimizu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Novel Three-Dimensional Human Peritubular Microvascular System

(2015) G. Ligresti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

(2015) Norhana Jusoh et al.   LAB ON A CHIP

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Functional differentiation of human pluripotent stem cells on a chip

(2015) Giovanni G Giobbe et al.   NATURE METHODS

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells

(2015) Julien Maruotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Strategies for improving the physiological relevance of human engineered tissues

(2015) Rosalyn D. Abbott et al.   TRENDS IN BIOTECHNOLOGY

Central Nervous System and its Disease Models on a Chip

(2015) YoonYoung Yi et al.   TRENDS IN BIOTECHNOLOGY

Electrically conductive polymers and composites for biomedical applications

(2015) Gagan Kaur et al.   RSC Advances

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

(2015) Hansang Cho et al.   Scientific Reports

Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

(2015) Sara Bagherifard et al.   Advanced Healthcare Materials

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients

(2015) Won Kyung Song et al.   Stem Cell Reports

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

Imaging of oxygen in microreactors and microfluidic systems

(2015) Shiwen Sun et al.   Methods and Applications in Fluorescence

Microfluidic platforms employing integrated fluorescent or luminescent chemical sensors: a review of methods, scope and applications

(2015) Simon A Pfeiffer et al.   Methods and Applications in Fluorescence

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

The application of 3D cell models to support drug safety assessment: Opportunities & challenges

(2014) Adrian Roth et al.   ADVANCED DRUG DELIVERY REVIEWS

Low cost referenced luminescent imaging of oxygen and pH with a 2-CCD colour near infrared camera

(2014) Josef Ehgartner et al.   ANALYST

Microfluidic approaches for epithelial cell layer culture and characterisation

(2014) Roland Thuenauer et al.   ANALYST

Electrochemical Sensors and Biosensors Based on Nanomaterials and Nanostructures

(2014) Chengzhou Zhu et al.   ANALYTICAL CHEMISTRY

Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics

(2014) Zimple Matharu et al.   ANALYTICAL CHEMISTRY

Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model

(2014) R. Booth et al.   ANNALS OF BIOMEDICAL ENGINEERING

Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues

(2014) Megan L. McCain et al.   BIOMATERIALS

Induced pluripotent stem cell-derived hepatocytes and endothelial cells in multi-component hydrogel fibers for liver tissue engineering

(2014) Chan Du et al.   BIOMATERIALS

Optical methods for sensing and imaging oxygen: materials, spectroscopies and applications

(2014) Xu-dong Wang et al.   CHEMICAL SOCIETY REVIEWS

Dynamic Changes in Myocardial Matrix and Relevance to Disease

(2014) Ai-Hsien Li et al.   CIRCULATION RESEARCH

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells

(2014) Lauren L. Bischel et al.   Integrative Biology

Construction of a collagen-based, split-thickness cornea substitute

(2014) A. Acun et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Preparation andin vitrocytocompatibility of chitosan-siloxane hybrid hydrogels

(2014) Yuki Shirosaki et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Cell sheet approach for tissue engineering and regenerative medicine

(2014) Katsuhisa Matsuura et al.   JOURNAL OF CONTROLLED RELEASE

The Use of Microtechnology and Nanotechnology in Fabricating Vascularized Tissues

(2014) Raquel Obregón et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Biomaterials in myocardial tissue engineering

(2014) Lewis A. Reis et al.   Journal of Tissue Engineering and Regenerative Medicine

One-step surface modification for irreversible bonding of various plastics with a poly(dimethylsiloxane) elastomer at room temperature

(2014) Jing Wu et al.   LAB ON A CHIP

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

Microfluidic single-cell analysis for systems immunology

(2014) Michael Junkin et al.   LAB ON A CHIP

Approaching the in vitro clinical trial: engineering organs on chips

(2014) A. K. Capulli et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

An extracorporeal blood-cleansing device for sepsis therapy

(2014) Joo H Kang et al.   NATURE MEDICINE

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Microfluidic Thrombosis under Multiple Shear Rates and Antiplatelet Therapy Doses

(2014) Melissa Li et al.   PLoS One

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitin and chitosan in selected biomedical applications

(2014) A. Anitha et al.   PROGRESS IN POLYMER SCIENCE

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

(2014) Thibault Bricks et al.   TOXICOLOGY IN VITRO

Bioreactor for modulation of cardiac microtissue phenotype by combined static stretch and electrical stimulation

(2014) Jason W Miklas et al.   Biofabrication

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Stiff substrates enhance cultured neuronal network activity

(2014) Quan-You Zhang et al.   Scientific Reports

In Situ Generation of Tunable Porosity Gradients in Hydrogel-Based Scaffolds for Microfluidic Cell Culture

(2014) Aswan Al-Abboodi et al.   Advanced Healthcare Materials

3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering

(2014) Claudia Fuoco et al.   Frontiers in Physiology

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

Micro- and nanofabrication of chitosan structures for regenerative engineering

(2013) Tao Jiang et al.   Acta Biomaterialia

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

(2013) Goran T. Vladisavljević et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidics for nano-pathophysiology

(2013) Kae Sato et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture

(2013) Martin E. Kolewe et al.   ADVANCED MATERIALS

Dielectrophoretically Aligned Carbon Nanotubes to Control Electrical and Mechanical Properties of Hydrogels to Fabricate Contractile Muscle Myofibers

(2013) Javier Ramón-Azcón et al.   ADVANCED MATERIALS

Quantification of ovarian cancer markers with integrated microfluidic concentration gradient and imaging nanohole surface plasmon resonance

(2013) Carlos Escobedo et al.   ANALYST

On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles

(2013) Donghyuk Kim et al.   ANALYST

Microfluidic Chip with Integrated Electrical Cell-Impedance Sensing for Monitoring Single Cancer Cell Migration in Three-Dimensional Matrixes

(2013) Tien Anh Nguyen et al.   ANALYTICAL CHEMISTRY

Electrochemical Properties of Nanostructured Porous Gold Electrodes in Biofouling Solutions

(2013) Jay Patel et al.   ANALYTICAL CHEMISTRY

Biomaterials for Tissue Engineering

(2013) Esther J. Lee et al.   ANNALS OF BIOMEDICAL ENGINEERING

Use of Flow, Electrical, and Mechanical Stimulation to Promote Engineering of Striated Muscles

(2013) Swathi Rangarajan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of microscaffold properties in controlling the collagen assembly in 3D dermis equivalent using modular tissue engineering

(2013) Giorgia Imparato et al.   BIOMATERIALS

Three-dimensional neuron–muscle constructs with neuromuscular junctions

(2013) Yuya Morimoto et al.   BIOMATERIALS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Current approaches to electrospun nanofibers for tissue engineering

(2013) Nae Gyune Rim et al.   Biomedical Materials

Serum-free media for the production of human mesenchymal stromal cells: a review

(2013) S. Gottipamula et al.   CELL PROLIFERATION

Exploring Living Multicellular Organisms, Organs, and Tissues Using Microfluidic Systems

(2013) Venkataragavalu Sivagnanam et al.   CHEMICAL REVIEWS

Luminescent probes and sensors for temperature

(2013) Xu-dong Wang et al.   CHEMICAL SOCIETY REVIEWS

Fluorescence resonance energy transfer imaging of cell signaling fromin vitrotoin vivo: Basis of biosensor construction, live imaging, and image processing

(2013) Kazuhiro Aoki et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In vitro models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reconstructed skin models as emerging tools for drug absorption studies

(2013) Sarah Küchler et al.   Expert Opinion on Drug Metabolism & Toxicology

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Systematic Reviews of Animal Models: Methodology versus Epistemology

(2013) Ray Greek et al.   International Journal of Medical Sciences

Time-dependent functional maturation of scaffold-free cartilage tissue analogs

(2013) Bhavana Mohanraj et al.   JOURNAL OF BIOMECHANICS

Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model

(2013) Scott S. Verbridge et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments

(2013) Jaewon Park et al.   JOURNAL OF NEUROSCIENCE METHODS

Investigation of nerve injury through microfluidic devices

(2013) R. Siddique et al.   Journal of the Royal Society Interface

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

(2013) Björn Harink et al.   LAB ON A CHIP

The future of the patient-specific Body-on-a-chip

(2013) Adam Williamson et al.   LAB ON A CHIP

Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads

(2013) Lin Wang et al.   LAB ON A CHIP

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

(2013) Chen-Ta Ho et al.   LAB ON A CHIP

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Microfluidic titer plate for stratified 3D cell culture

(2013) Sebastiaan J. Trietsch et al.   LAB ON A CHIP

Hydrogel-coated microfluidic channels for cardiomyocyte culture

(2013) Nasim Annabi et al.   LAB ON A CHIP

Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient

(2013) Ryan W. Muthard et al.   LAB ON A CHIP

Control of neural network patterning using collagen gel photothermal etching

(2013) Aoi Odawara et al.   LAB ON A CHIP

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Effects of the Electrode Size and Modification Protocol on a Label-Free Electrochemical Biosensor

(2013) Sunil K. Arya et al.   LANGMUIR

Margination Propensity of Vascular-Targeted Spheres from Blood Flow in a Microfluidic Model of Human Microvessels

(2013) Katawut Namdee et al.   LANGMUIR

Galactose-Functionalized Gelatin Hydrogels Improve the Functionality of Encapsulated Hepg2 Cells

(2013) Elien Gevaert et al.   MACROMOLECULAR BIOSCIENCE

Gold Nanoparticle Loaded Hybrid Nanofibers for Cardiogenic Differentiation of Stem Cells for Infarcted Myocardium Regeneration

(2013) Rajeswari Ravichandran et al.   MACROMOLECULAR BIOSCIENCE

Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks

(2013) Giuseppina Lamberti et al.   MICROVASCULAR RESEARCH

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Formation of microvascular networks in vitro

(2013) John P Morgan et al.   Nature Protocols

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Biosensing using straight long-range surface plasmon waveguides

(2013) Oleksiy Krupin et al.   OPTICS EXPRESS

Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation

(2013) Thomas Biedermann et al.   PEDIATRIC SURGERY INTERNATIONAL

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II

(2013) Francesco Dituri et al.   PLoS One

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Enhancement of Renal Epithelial Cell Functions through Microfluidic-Based Coculture with Adipose-Derived Stem Cells

(2013) Hui-Chun Huang et al.   TISSUE ENGINEERING PART A

Skeletal Muscle Tissue Engineering: Methods to Form Skeletal Myotubes and Their Applications

(2013) Serge Ostrovidov et al.   TISSUE ENGINEERING PART B-REVIEWS

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Real-time optical pH measurement in a standard microfluidic cell culture system

(2013) Einar B. Magnusson et al.   Biomedical Optics Express

A three-dimensional neuronal culture technique that controls the direction of neurite elongation and the position of soma to mimic the layered structure of the brain

(2013) Aoi Odawara et al.   RSC Advances

Physical influences on stem cells

(2013) Gordana Vunjak-Novakovic   Stem Cell Research & Therapy

Progress in Using Systematic Reviews of Animal Studies to Improve Translational Research

(2013) C. R. Hooijmans et al.   PLOS MEDICINE

Microfluidic approaches for engineering vasculature

(2013) Joe Tien   Current Opinion in Chemical Engineering

Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers

(2012) Bhaskara V. Chikkaveeraiah et al.   ACS Nano

Alignment of multi-layered muscle cells within three-dimensional hydrogel macrochannels

(2012) Stephanie L. Hume et al.   Acta Biomaterialia

Biodegradation and biocompatibility of PLA and PLGA microspheres

(2012) James M. Anderson et al.   ADVANCED DRUG DELIVERY REVIEWS

Fiber-Optic Chemical Sensors and Biosensors (2008–2012)

(2012) Xu-Dong Wang et al.   ANALYTICAL CHEMISTRY

Cancer Biomarker Detection in Serum Samples Using Surface Plasmon Resonance and Quartz Crystal Microbalance Sensors with Nanoparticle Signal Amplification

(2012) Yildiz Uludag et al.   ANALYTICAL CHEMISTRY

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

Overflow Microfluidic Networks: Application to the Biochemical Analysis of Brain Cell Interactions in Complex Neuroinflammatory Scenarios

(2012) Fabio Bianco et al.   ANALYTICAL CHEMISTRY

Investigation of Hypoxia-Induced Myocardial Injury Dynamics in a Tissue Interface Mimicking Microfluidic Device

(2012) Li Ren et al.   ANALYTICAL CHEMISTRY

Microfluidic System for Facilitated Quantification of Nanoparticle Accumulation to Cells Under Laminar Flow

(2012) Jiro Kusunose et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microfluidic Models of Vascular Functions

(2012) Keith H.K. Wong et al.   Annual Review of Biomedical Engineering

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

The influence of substrate stiffness on the behavior and functions of Schwann cells in culture

(2012) Yun Gu et al.   BIOMATERIALS

A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering

(2012) Thomas Billiet et al.   BIOMATERIALS

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hyaluronic acid based scaffolds for tissue engineering—A review

(2012) Maurice N. Collins et al.   CARBOHYDRATE POLYMERS

Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes

(2012) Ramzi Shawahna et al.   CURRENT DRUG METABOLISM

A new mechanobiological era: microfluidic pathways to apply and sense forces at the cellular level

(2012) Felix Kurth et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The multicellular tumor spheroid model for high-throughput cancer drug discovery

(2012) Daniel V LaBarbera et al.   Expert Opinion on Drug Discovery

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Evaluation of gastrointestinal drug supersaturation and precipitation: Strategies and issues

(2012) Jan Bevernage et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

(2012) Sari Pappinen et al.   JOURNAL OF CONTROLLED RELEASE

A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons

(2012) Xi Lu et al.   JOURNAL OF NEUROSCIENCE METHODS

Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.

(2012) Peter Scherp et al.   Journal of Proteomics

Electrode Placement and Fluid Flow Rates in Microfluidic Electrochemical Devices

(2012) E. Victoria Dydek et al.   JOURNAL OF THE ELECTROCHEMICAL SOCIETY

Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications

(2012) Hojae Bae et al.   Journal of Tissue Engineering and Regenerative Medicine

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

(2012) Javier Ramón-Azcón et al.   LAB ON A CHIP

Multi-compartment neuron–glia co-culture platform for localized CNS axon–glia interaction study

(2012) Jaewon Park et al.   LAB ON A CHIP

A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

(2012) Qian Zhang et al.   LAB ON A CHIP

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils

(2012) Sewoon Han et al.   LAB ON A CHIP

Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

(2012) Raymond H. W. Lam et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Interdigitated array of Pt electrodes for electrical stimulation and engineering of aligned muscle tissue

(2012) Samad Ahadian et al.   LAB ON A CHIP

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

(2012) Mahmut Selman Sakar et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Brain slice on a chip: opportunities and challenges of applying microfluidic technology to intact tissues

(2012) Yu Huang et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Construction of oxygen and chemical concentration gradients in a single microfluidic device for studying tumor cell–drug interactions in a dynamic hypoxia microenvironment

(2012) Lei Wang et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

(2012) G. T. Vladisavljević et al.   Microfluidics and Nanofluidics

In vitro cell migration and invasion assays

(2012) Nina Kramer et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

(2012) Bozhi Tian et al.   NATURE MATERIALS

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

Perfusable branching microvessel bed for vascularization of engineered tissues

(2012) L. L. Y. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional cardiac tissue engineering

(2012) Brian Liau et al.   Regenerative Medicine

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Wetting transitions of cellular aggregates induced by substrate rigidity

(2012) Stéphane Douezan et al.   Soft Matter

Stem Cell Sources for Vascular Tissue Engineering and Regeneration

(2012) Vivek K. Bajpai et al.   TISSUE ENGINEERING PART B-REVIEWS

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

(2012) Sébastien Anthérieu et al.   TOXICOLOGY IN VITRO

Construction of 3D, Layered Skin, Microsized Tissues by Using Cell Beads for Cellular Function Analysis

(2012) Yuya Morimoto et al.   Advanced Healthcare Materials

Patterned Three-Dimensional Encapsulation of Embryonic Stem Cells using Dielectrophoresis and Stereolithography

(2012) Piyush Bajaj et al.   Advanced Healthcare Materials

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Micro- and Nanotechnologies for Study of Cell Secretion

(2011) Yinxi Huang et al.   ANALYTICAL CHEMISTRY

Electrochemical Sensors and Biosensors

(2011) Danielle W. Kimmel et al.   ANALYTICAL CHEMISTRY

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Concave microwell based size-controllable hepatosphere as a three-dimensional liver tissue model

(2011) Sau Fung Wong et al.   BIOMATERIALS

A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology

(2011) Chen-Chie Wang et al.   BIOMATERIALS

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease

(2011) Azadeh Seidi et al.   Biomicrofluidics

Diverse approaches for the enhancement of oral drug bioavailability

(2011) Pius Fasinu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Study of Cell-Matrix Adhesion Dynamics Using Surface Plasmon Resonance Imaging Ellipsometry

(2011) Se-Hwa Kim et al.   BIOPHYSICAL JOURNAL

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Co-pathological connected primary neurons in a microfluidic device for alzheimer studies

(2011) Anja Kunze et al.   BIOTECHNOLOGY AND BIOENGINEERING

Vascular endothelial growth factor is upregulated by l-dopa in the parkinsonian brain: implications for the development of dyskinesia

(2011) K. Elisabet Ohlin et al.   BRAIN

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

(2011) Meggie M.G. Grafton et al.   Integrative Biology

Skeletal myotube formation enhanced by electrospun polyurethane carbon nanotube scaffolds

(2011) Sirinrath Sirivisoot et al.   International Journal of Nanomedicine

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Controlled release of thymosin β4 using collagen–chitosan composite hydrogels promotes epicardial cell migration and angiogenesis

(2011) Loraine L.Y. Chiu et al.   JOURNAL OF CONTROLLED RELEASE

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Culturing Pancreatic Islets in Microfluidic Flow Enhances Morphology of the Associated Endothelial Cells

(2011) Krishana S. Sankar et al.   PLoS One

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Concise Review: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: Close Enough or Yet Too Far Apart?

(2011) Josipa Bilic et al.   STEM CELLS

Mechanoregulation of Vascularization in Aligned Tissue-Engineered Muscle: A Role for Vascular Endothelial Growth Factor

(2011) Daisy W.J. van der Schaft et al.   TISSUE ENGINEERING PART A

Uniaxial Cyclic Strain Drives Assembly and Differentiation of Skeletal Myocytes

(2011) Cristian Pablo Pennisi et al.   TISSUE ENGINEERING PART A

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Microengineering methods for cell-based microarrays and high-throughput drug-screening applications

(2011) Feng Xu et al.   Biofabrication

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications

(2010) Adam L. Washburn et al.   ANALYST

Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor

(2010) Régis Baudoin et al.   BIOCHEMICAL ENGINEERING JOURNAL

Rat hepatocyte aggregate formation on discrete aligned nanofibers of type-I collagen-coated poly(l-lactic acid)

(2010) Zhang-Qi Feng et al.   BIOMATERIALS

Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness

(2010) Hirokazu Kaji et al.   BIOMATERIALS

Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering

(2010) Junmin Zhu   BIOMATERIALS

Toward modeling the bone marrow niche using scaffold-based 3D culture systems

(2010) Nunzia Di Maggio et al.   BIOMATERIALS

Enzyme-coated microelectrodes to monitor lactate production in a nanoliter microfluidic cell culture device

(2010) Igor A. Ges et al.   BIOSENSORS & BIOELECTRONICS

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

(2010) Cheul Cho et al.   BIOTECHNIQUES

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice

(2010) Ronald Y Kwon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System

(2010) Luca Cucullo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

(2010) Ganna Bilousova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Addition of glutamate to serum-free culture promotes recovery of electrical activity in adult hippocampal neurons in vitro

(2010) Darin Edwards et al.   JOURNAL OF NEUROSCIENCE METHODS

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

(2010) K. Lee et al.   Journal of the Royal Society Interface

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Building and manipulating neural pathways with microfluidics

(2010) Yevgeny Berdichevsky et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

(2010) Mazher-Iqbal Mohammed et al.   LAB ON A CHIP

Spatiotemporally controlled contraction of micropatterned skeletal muscle cells on a hydrogel sheet

(2010) Kuniaki Nagamine et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Engineering hydrogels as extracellular matrix mimics

(2010) Hikmet Geckil et al.   Nanomedicine

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Optical Oxygen Sensors for Applications in Microfluidic Cell Culture

(2010) Samantha M. Grist et al.   SENSORS

Synthesis and characterization of a biodegradable elastomer featuring a dual crosslinking mechanism

(2010) Richard T. Tran et al.   Soft Matter

Fibrin Degradation Enhances Vascular Smooth Muscle Cell Proliferation and Matrix Deposition in Fibrin-Based Tissue Constructs Fabricated In Vitro

(2010) Katherine A. Ahmann et al.   TISSUE ENGINEERING PART A

Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

(2010) J. van der Valk et al.   TOXICOLOGY IN VITRO

Biodegradation, biodistribution and toxicity of chitosan

(2009) T. Kean et al.   ADVANCED DRUG DELIVERY REVIEWS

Chitosan-based hydrogels for controlled, localized drug delivery

(2009) Narayan Bhattarai et al.   ADVANCED DRUG DELIVERY REVIEWS

Quantitative Detection of Bioassays with a Low-Cost Image-Sensor Array for Integrated Microsystems

(2009) Daynene M. Vykoukal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function

(2009) Zhang-Qi Feng et al.   BIOMATERIALS

Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices

(2009) Kyung Eun Sung et al.   BIOMATERIALS

The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices

(2009) Babette Lanfer et al.   BIOMATERIALS

The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds

(2009) Bing Li et al.   BIOMATERIALS

In vitro evaluation of a multi-layer radial-flow bioreactor based on galactosylated chitosan nanofiber scaffolds

(2009) Xue-Hui Chu et al.   BIOMATERIALS

Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology

(2009) Tadashi Sasagawa et al.   BIOMATERIALS

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Surface plasmon resonance imaging for affinity-based biosensors

(2009) Simona Scarano et al.   BIOSENSORS & BIOELECTRONICS

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders

(2009) Z. Ye et al.   BLOOD

Fluorescent Indicators for Intracellular pH

(2009) Junyan Han et al.   CHEMICAL REVIEWS

Chiral and structural analysis of biomolecules using mass spectrometry and ion mobility-mass spectrometry

(2009) Jeffrey R. Enders et al.   CHIRALITY

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Automated drug screening with contractile muscle tissue engineered from dystrophic myoblasts

(2009) Herman Vandenburgh et al.   FASEB JOURNAL

Transport-mediated angiogenesis in 3D epithelial coculture

(2009) Ryo Sudo et al.   FASEB JOURNAL

Articular cartilage tissue engineering

(2009) A. Getgood et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers

(2009) R. Chapanian et al.   JOURNAL OF CONTROLLED RELEASE

Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy

(2009) M.R. TADROSS et al.   JOURNAL OF MICROSCOPY

Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering

(2009) K. Nagase et al.   Journal of the Royal Society Interface

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

An integrated microfluidic device for large-scale in situ click chemistry screening

(2009) Yanju Wang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

(2009) Christopher M. Puleo et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Applications, techniques, and microfluidic interfacing for nanoscale biosensing

(2009) Jungkyu Kim et al.   Microfluidics and Nanofluidics

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Parkinson chimera

(2009) A. J. Lees   NEUROLOGY

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

(2009) J. S. Henkel et al.   NEUROLOGY

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth

(2009) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paper-supported 3D cell culture for tissue-based bioassays

(2009) R. Derda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

(2009) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion-Sensitive Field-Effect Transistor for Biological Sensing

(2009) Chang-Soo Lee et al.   SENSORS

Electrical Stimulation of Nerve Cells Using Conductive Nanofibrous Scaffolds for Nerve Tissue Engineering

(2009) Laleh Ghasemi-Mobarakeh et al.   TISSUE ENGINEERING PART A

Challenges in Cardiac Tissue Engineering

(2009) Gordana Vunjak-Novakovic et al.   TISSUE ENGINEERING PART B-REVIEWS

A Novel Bioreactor for Stimulating Skeletal Muscle In Vitro

(2009) Kenneth Donnelly et al.   TISSUE ENGINEERING PART C-METHODS

A catch-up validation study on reconstructed human epidermis (SkinEthic™ RHE) for full replacement of the Draize skin irritation test

(2009) Nathalie Alépée et al.   TOXICOLOGY IN VITRO

Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering

(2009) M. Grellier et al.   TRENDS IN BIOTECHNOLOGY

A Dual Luminescent Sensor Material for Simultaneous Imaging of Pressure and Temperature on Surfaces

(2008) Matthias I. J. Stich et al.   ADVANCED FUNCTIONAL MATERIALS

Chemiluminometric enzyme-linked immunosorbent assays (ELISA)-on-a-chip biosensor based on cross-flow chromatography

(2008) Il-Hoon Cho et al.   ANALYTICA CHIMICA ACTA

Method for simultaneous luminescence sensing of two species using optical probes of different decay time, and its application to an enzymatic reaction at varying temperature

(2008) Stefan Nagl et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Microfluidic immunosensor design for the quantification of interleukin-6 in human serum samples

(2008) Germán A. Messina et al.   ANALYTICAL BIOCHEMISTRY

Detection of the Superoxide Radical Anion Using Various Alkanethiol Monolayers and Immobilized Cytochromec

(2008) Xiaojun J. Chen et al.   ANALYTICAL CHEMISTRY

Cell Motion Model for Moving Dielectrophoresis

(2008) Chin Hock Kua et al.   ANALYTICAL CHEMISTRY

Recombinant human collagen for tissue engineered corneal substitutes

(2008) Wenguang Liu et al.   BIOMATERIALS

Electrospinning: Applications in drug delivery and tissue engineering

(2008) Travis J. Sill et al.   BIOMATERIALS

In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry

(2008) Joan E. Nichols et al.   BIOMATERIALS

Silk film biomaterials for cornea tissue engineering

(2008) Brian D. Lawrence et al.   BIOMATERIALS

The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model

(2008) Jiashing Yu et al.   BIOMATERIALS

The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation

(2008) Gregory T. Christopherson et al.   BIOMATERIALS

Development of high throughput optical sensor array for on-line pH monitoring in micro-scale cell culture environment

(2008) Min-Hsien Wu et al.   BIOMEDICAL MICRODEVICES

Development of a stable dual cell-line GFP expression system to study estrogenic endocrine disruptors

(2008) Hui Xu et al.   BIOTECHNOLOGY AND BIOENGINEERING

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers

(2008) I-Chien Liao et al.   Cellular and Molecular Bioengineering

Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species

(2008) Jiří Homola   CHEMICAL REVIEWS

Optical Chemical Sensors

(2008) Colette McDonagh et al.   CHEMICAL REVIEWS

Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells

(2008) Matthias Stadtfeld et al.   CURRENT BIOLOGY

Tissue engineering: strategies, stem cells and scaffolds

(2008) Daniel Howard et al.   JOURNAL OF ANATOMY

Extracellular matrix dynamics in development and regenerative medicine

(2008) W. P. Daley et al.   JOURNAL OF CELL SCIENCE

HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells

(2008) Alessandra Rossini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tissue-Engineered Spleen Protects Against Overwhelming Pneumococcal Sepsis in a Rodent Model

(2008) Tracy C. Grikscheit et al.   JOURNAL OF SURGICAL RESEARCH

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

In-situ measurement of cellular microenvironments in a microfluidic device

(2008) Zhang Lin et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes

(2008) Hoi Ting Heidi Au et al.   LAB ON A CHIP

Luminescent nanobeads for optical sensing and imaging of dissolved oxygen

(2008) Sergey M. Borisov et al.   MICROCHIMICA ACTA

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Generation of pluripotent stem cells from adult human testis

(2008) Sabine Conrad et al.   NATURE

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

(2008) Lei Yang et al.   NATURE

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

(2008) Trond Aasen et al.   NATURE BIOTECHNOLOGY

Collagen Tissue Engineering: Development of Novel Biomaterials and Applications

(2008) Lian Cen et al.   PEDIATRIC RESEARCH

Generation of human induced pluripotent stem cells from dermal fibroblasts

(2008) W. E. Lowry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrochemical Biosensors - Sensor Principles and Architectures

(2008) Dorothee Grieshaber et al.   SENSORS

Feasibility Study of a Novel Urinary Bladder Bioreactor

(2008) M. Chad Wallis et al.   TISSUE ENGINEERING PART A

Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration

(2007) Erik E. Krommenhoek et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic large-scale integration on a chip for mass production of monodisperse droplets and particles

(2007) Takasi Nisisako et al.   LAB ON A CHIP

Genomics and proteomics analysis of cultured primary rat hepatocytes

(2007) Juergen Beigel et al.   TOXICOLOGY IN VITRO

Aptamer-based biosensors

(2007) Shiping Song et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS