Revisiting lab-on-a-chip technology for drug discovery

Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms

(2012) R. M. Pruss   CNS & Neurological Disorders-Drug Targets

Thermoforming of Film-Based Biomedical Microdevices

(2011) Roman Truckenmüller et al.   ADVANCED MATERIALS

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Ion channel electrophysiology via integrated planar patch-clamp chip with on-demand drug exchange

(2011) Chang-Yu Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Stem cell biology and drug discovery

(2011) Lee L Rubin et al.   BMC BIOLOGY

Biomaterials meet microfluidics: building the next generation of artificial niches

(2011) Stefan Kobel et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Microfluidic Technologies for Synthetic Biology

(2011) Parisutham Vinuselvi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fundamentals and applications of immobilized microfluidic enzymatic reactors

(2011) Sandro Matosevic et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

(2011) Deniz Pekin et al.   LAB ON A CHIP

Responsive Microgrooves for the Formation of Harvestable Tissue Constructs

(2011) Halil Tekin et al.   LANGMUIR

A living system on a chip

(2011) Monya Baker   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A microdroplet dilutor for high-throughput screening

(2011) Xize Niu et al.   Nature Chemistry

Micropilot: automation of fluorescence microscopy–based imaging for systems biology

(2011) Christian Conrad et al.   NATURE METHODS

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Droplet microfluidics with magnetic beads: a new tool to investigate drug–protein interactions

(2010) Dario Lombardi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The beautiful cell: high-content screening in drug discovery

(2010) Marc Bickle   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cell-Free Expression of Soluble and Membrane Proteins in an Array Device for Drug Screening

(2010) Ruba Khnouf et al.   ANALYTICAL CHEMISTRY

Latest Developments in Micro Total Analysis Systems

(2010) Arun Arora et al.   ANALYTICAL CHEMISTRY

Quantitative Enzyme Activity Determination with Zeptomole Sensitivity by Microfluidic Gradient-Gel Zymography

(2010) Alex J. Hughes et al.   ANALYTICAL CHEMISTRY

High-throughput methods to define complex stem cell niches

(2010) Stefan Kobel et al.   BIOTECHNIQUES

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Multiplexed, high-throughput analysis of 3D microtissue suspensions

(2010) Alice A. Chen et al.   Integrative Biology

Lateral patch-clamping in a standard 1536-well microplate format

(2010) Kum Cheong Tang et al.   LAB ON A CHIP

Planar digital nanoliter dispensing system based on thermocapillary actuation

(2010) Anton A. Darhuber et al.   LAB ON A CHIP

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Towards high throughput production of artificial egg oocytes using microfluidics

(2010) A. M. Jimenez et al.   LAB ON A CHIP

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

A microfluidic array for large-scale ordering and orientation of embryos

(2010) Kwanghun Chung et al.   NATURE METHODS

Screening: the age of fishes

(2010) Monya Baker   NATURE METHODS

A microfluidic oligonucleotide synthesizer

(2010) Cheng-Chung Lee et al.   NUCLEIC ACIDS RESEARCH

Single cell trapping and DNA damage analysis using microwell arrays

(2010) D. K. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

(2010) S. L. Stott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Unveiling the role of network and systems biology in drug discovery

(2010) Albert Pujol et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Artificial Stem Cell Niches

(2009) Matthias P. Lutolf et al.   ADVANCED MATERIALS

High-Throughput Analysis of Alzheimer’s β-Amyloid Aggregation Using a Microfluidic Self-Assembly of Monomersf

(2009) Joon Seok Lee et al.   ANALYTICAL CHEMISTRY

The impact of synthetic biology on drug discovery

(2009) Wilfried Weber et al.   DRUG DISCOVERY TODAY

Geometry and force control of cell function

(2009) Donald O. Freytes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Opportunities for microfluidic technologies in synthetic biology

(2009) S. Gulati et al.   Journal of the Royal Society Interface

Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices

(2009) Thomas Franke et al.   LAB ON A CHIP

Microvalve-actuated precise control of individual droplets in microfluidic devices

(2009) Shaojiang Zeng et al.   LAB ON A CHIP

Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing

(2009) Xiaole Mao et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW)

(2009) Jinjie Shi et al.   LAB ON A CHIP

Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW)

(2009) Jinjie Shi et al.   LAB ON A CHIP

Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity

(2009) Jean-Christophe Baret et al.   LAB ON A CHIP

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

(2009) S. Elizabeth Hulme et al.   LAB ON A CHIP

Programming cells by multiplex genome engineering and accelerated evolution

(2009) Harris H. Wang et al.   NATURE

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Gene Networks That Count

(2009) A. E. Friedland et al.   SCIENCE

Microtechnologies for membrane protein studies

(2008) Hiroaki Suzuki et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Real-Time Microfluidic System for Studying Mammalian Cells in 3D Microenvironments

(2008) Jerry Lii et al.   ANALYTICAL CHEMISTRY

From Microdroplets to Microfluidics: Selective Emulsion Separation in Microfluidic Devices

(2008) Luis M. Fidalgo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Subpicoliter droplet generation based on a nozzle-free acoustic transducer

(2008) Chuang-Yuan Lee et al.   APPLIED PHYSICS LETTERS

Stem Cells and Drug Discovery: The Beginning of a New Era?

(2008) Lee L. Rubin   CELL

Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms

(2008) Jenifer Clausell-Tormos et al.   CHEMISTRY & BIOLOGY

Droplet-based microfluidic system for individual Caenorhabditis elegans assay

(2008) Weiwei Shi et al.   LAB ON A CHIP

Controlled encapsulation of single-cells into monodisperse picolitre drops

(2008) Jon F. Edd et al.   LAB ON A CHIP

Droplet microfluidics

(2008) Shia-Yen Teh et al.   LAB ON A CHIP

DEP actuated nanoliter droplet dispensing using feedback control

(2008) Kai-Liang Wang et al.   LAB ON A CHIP

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

(2008) Shirit Einav et al.   NATURE BIOTECHNOLOGY

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY

Microscopic imaging techniques for drug discovery

(2007) Andrew Bullen   NATURE REVIEWS DRUG DISCOVERY

Genomics and proteomics analysis of cultured primary rat hepatocytes

(2007) Juergen Beigel et al.   TOXICOLOGY IN VITRO