Microengineered physiological biomimicry: Organs-on-Chips

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Mechanochemical Control of Mesenchymal Condensation and Embryonic Tooth Organ Formation

(2011) Tadanori Mammoto et al.   DEVELOPMENTAL CELL

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

(2011) Meggie M.G. Grafton et al.   Integrative Biology

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Culturing Pancreatic Islets in Microfluidic Flow Enhances Morphology of the Associated Endothelial Cells

(2011) Krishana S. Sankar et al.   PLoS One

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

(2010) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

(2010) Yu-suke Torisawa et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

(2010) Kyung-Jin Jang et al.   Integrative Biology

A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes

(2010) Alexander J. Blake et al.   JOURNAL OF NEUROSCIENCE METHODS

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

(2009) Christopher M. Puleo et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Paper-supported 3D cell culture for tissue-based bioassays

(2009) R. Derda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA