Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

A versatile lab-on-a-chip tool for modeling biological barriers

(2016) Fruzsina R. Walter et al.   SENSORS AND ACTUATORS B-CHEMICAL

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Human brain microvascular endothelial cells resist elongation due to shear stress

(2015) Adam Reinitz et al.   MICROVASCULAR RESEARCH

LRP-1-mediated intracellular antibody delivery to the Central Nervous System

(2015) Xiaohe Tian et al.   Scientific Reports

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

(2015) Hansang Cho et al.   Scientific Reports

Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model

(2014) R. Booth et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Brain microvascular endothelial cells resist elongation due to curvature and shear stress

(2014) Mao Ye et al.   Scientific Reports

Endothelial Cell Sensing of Flow Direction

(2013) Chong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy

(2013) Lingyan Shi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Stroke-Induced Brain Parenchymal Injury Drives Blood–Brain Barrier Early Leakage Kinetics: A Combined in Vivo/in Vitro Study

(2013) Mélanie Kuntz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

(2013) Margaret L Sutherland et al.   Stem Cell Research & Therapy

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood–brain barrier model

(2012) Carina A. Cantrill et al.   BRAIN RESEARCH

Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes

(2012) Ramzi Shawahna et al.   CURRENT DRUG METABOLISM

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Transport of Arylsulfatase A across the Blood-Brain Barrierin Vitro

(2011) Frank Matthes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems

(2011) John F. Graf et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System

(2010) Luca Cucullo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane)

(2010) Vijaya Sunkara et al.   LAB ON A CHIP

Effect of Aging on Elastin Functionality in Human Cerebral Arteries

(2009) Edouard Fonck et al.   STROKE

Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses

(2008) Jinah Kim et al.   BIOMATERIALS

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH