Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells

(2015) B.-S. Ding et al.   JOURNAL OF CELL SCIENCE

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

(2015) Henry Danahay et al.   Cell Reports

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Macrophages Are Required for Dendritic Cell Uptake of Respiratory Syncytial Virus from an Infected Epithelium

(2014) Kelechi Ugonna et al.   PLoS One

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

(2014) Jiang Wu et al.   MedChemComm

Interleukin-6 neutralization alleviates pulmonary inflammation in mice exposed to cigarette smoke and poly(I:C)

(2013) Cedric Hubeau et al.   CLINICAL SCIENCE

Glucocorticoid insensitivity as a source of drug targets for respiratory disease

(2013) Alaina J Ammit   CURRENT OPINION IN PHARMACOLOGY

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

(2013) Tjerk Bueters et al.   DRUG DISCOVERY TODAY

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells

(2012) Giacomo Curradi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

(2012) R. Villenave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Asthma exacerbations: Origin, effect, and prevention

(2011) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alternative Spliced CD1D Transcripts in Human Bronchial Epithelial Cells

(2011) Kambez Hajipouran Benam et al.   PLoS One

Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma

(2010) Biju Thomas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Anatomy, pathology, and physiology of the tracheobronchial tree: Emphasis on the distal airways

(2009) Dallas M. Hyde et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukocyte - endothelial interactions in inflammation

(2009) Harald F. Langer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

(2008) Elizabeth Kudlacz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

(2008) Arnaud Didierlaurent et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe childhood asthma: a common international approach?

(2008) Andrew Bush et al.   LANCET