Microfluidic-Based Multi-Organ Platforms for Drug Discovery

High-content analysis of three-dimensional tumor spheroids: investigating signaling pathways using small hairpin RNA

(2018) Shane R Horman et al.   NATURE METHODS

On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

(2016) Chao Ma et al.   ANALYTICAL CHEMISTRY

Perfused drop microfluidic device for brain slice culture-based drug discovery

(2016) Jing Liu et al.   BIOMEDICAL MICRODEVICES

A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

(2016) Seyed Ali Mousavi Shaegh et al.   Biomicrofluidics

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Construction of a predictive model for evaluating multiple organ toxicity

(2016) Yu Ri An et al.   Molecular & Cellular Toxicology

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Liver and kidney cells cultures in a new perfluoropolyether biochip

(2016) Rachid Jellali et al.   SENSORS AND ACTUATORS B-CHEMICAL

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

EmergingIn VitroLiver Technologies for Drug Metabolism and Inter-Organ Interactions

(2016) Shyam Sundhar Bale et al.   TISSUE ENGINEERING PART B-REVIEWS

Development of a human physiologically based pharmacokinetic (PBPK) model for dermal permeability for lindane

(2016) Megan E. Sawyer et al.   TOXICOLOGY LETTERS

A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process

(2016) Fan An et al.   Scientific Reports

In silico toxicology: computational methods for the prediction of chemical toxicity

(2016) Arwa B. Raies et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Dogs as a Model for Cancer

(2016) Heather L. Gardner et al.   Annual Review of Animal Biosciences

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

Simple Microfluidic Approach to Fabricate Monodisperse Hollow Microparticles for Multidrug Delivery

(2015) Remigijus Vasiliauskas et al.   ACS Applied Materials & Interfaces

Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep

(2015) Karolina Theodoridis et al.   BIOMATERIALS

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

(2015) Thibault Bricks et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Microfluidic optoelectronic sensor for salivary diagnostics of stomach cancer

(2015) Yael Zilberman et al.   BIOSENSORS & BIOELECTRONICS

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

(2015) Muhammad Fawad Rasool et al.   CLINICAL PHARMACOKINETICS

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Biology coming full circle: Joining the whole and the parts

(2015) John P Wikswo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

In vitro micro-physiological models for translational immunology

(2015) Qasem Ramadan et al.   LAB ON A CHIP

Adding the ‘heart’ to hanging drop networks for microphysiological multi-tissue experiments

(2015) Saeed Rismani Yazdi et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Functional differentiation of human pluripotent stem cells on a chip

(2015) Giovanni G Giobbe et al.   NATURE METHODS

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity

(2015) Edward L. Croom et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models

(2015) F. Bonnier et al.   TOXICOLOGY IN VITRO

Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery

(2015) Sara Bagherifard et al.   Advanced Healthcare Materials

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

(2015) Eva-Maria Materne et al.   Jove-Journal of Visualized Experiments

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

(2015) Peter Loskill et al.   PLoS One

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

An integrative model of multi-organ drug-induced toxicity prediction using gene-expression data

(2014) Jinwoo Kim et al.   BMC BIOINFORMATICS

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

Cell-Based Biosensors and Their Application in Biomedicine

(2014) Qingjun Liu et al.   CHEMICAL REVIEWS

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Engineering and evaluating drug delivery particles in microfluidic devices

(2014) Mattias Björnmalm et al.   JOURNAL OF CONTROLLED RELEASE

A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids

(2014) Janine Ruppen et al.   LAB ON A CHIP

Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

(2014) Ho Yee Tiong et al.   MOLECULAR PHARMACEUTICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Various On-Chip Sensors with Microfluidics for Biological Applications

(2014) Hun Lee et al.   SENSORS

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

(2014) David G. Belair et al.   Stem Cell Reviews and Reports

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

(2014) Thibault Bricks et al.   TOXICOLOGY IN VITRO

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Automated single-cell motility analysis on a chip using lensfree microscopy

(2014) Ivan Pushkarsky et al.   Scientific Reports

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

(2013) Nasim Annabi et al.   ADVANCED MATERIALS

Microfluidic Chip with Integrated Electrical Cell-Impedance Sensing for Monitoring Single Cancer Cell Migration in Three-Dimensional Matrixes

(2013) Tien Anh Nguyen et al.   ANALYTICAL CHEMISTRY

Simultaneous Generation of Gradients with Gradually Changed Slope in a Microfluidic Device for Quantifying Axon Response

(2013) Rong-Rong Xiao et al.   ANALYTICAL CHEMISTRY

Simple, Low-Cost Styrene-Ethylene/Butylene-Styrene Microdevices for Electrokinetic Applications

(2013) Mark D. Borysiak et al.   ANALYTICAL CHEMISTRY

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

Functional ultrasound imaging for assessment of extracellular matrix scaffolds used for liver organoid formation

(2013) Ryan C. Gessner et al.   BIOMATERIALS

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

A microfluidic array for quantitative analysis of human neural stem cell self-renewal and differentiation in three-dimensional hypoxic microenvironment

(2013) Kisuk Yang et al.   BIOMATERIALS

Microfluidic-integrated biosensors: Prospects for point-of-care diagnostics

(2013) Suveen Kumar et al.   Biotechnology Journal

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

(2013) Nikolaos Tsamandouras et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies

(2013) Miroslav Dostalek et al.   CLINICAL PHARMACOKINETICS

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comprehension of drug toxicity: Software and databases

(2013) Andrey A. Toropov et al.   COMPUTERS IN BIOLOGY AND MEDICINE

PBPK models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reconstructed skin models as emerging tools for drug absorption studies

(2013) Sarah Küchler et al.   Expert Opinion on Drug Metabolism & Toxicology

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Hematopoietic stem cells for cancer immunotherapy

(2013) Eric Gschweng et al.   IMMUNOLOGICAL REVIEWS

A label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β2-adrenergic receptor

(2013) Ann M. Ferrie et al.   Integrative Biology

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Early Lung Cancer Diagnosis by Biosensors

(2013) Yuqian Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young

(2013) Adrian K. K. Teo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison and Possible Use ofIn SilicoTools for Carcinogenicity Within REACH Legislation

(2013) Chiara Milan et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

A microfluidic platform for chemical stimulation and real time analysis of catecholamine secretion from neuroendocrine cells

(2013) Igor A. Ges et al.   LAB ON A CHIP

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

The future of the patient-specific Body-on-a-chip

(2013) Adam Williamson et al.   LAB ON A CHIP

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

(2013) Brendon M. Baker et al.   LAB ON A CHIP

Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations

(2013) Man-Chi Liu et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Simple replica micromolding of biocompatible styrenic elastomers

(2013) Mark D. Borysiak et al.   LAB ON A CHIP

Toward giga-pixel nanoscopy on a chip: a computational wide-field look at the nano-scale without the use of lenses

(2013) Euan McLeod et al.   LAB ON A CHIP

Research highlights

(2013) Šeila Selimović et al.   LAB ON A CHIP

Wide-field optical detection of nanoparticles using on-chip microscopy and self-assembled nanolenses

(2013) Onur Mudanyali et al.   Nature Photonics

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

(2013) J D Zhang et al.   PHARMACOGENOMICS JOURNAL

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Allometry of brain metabolism: Fig. 1.

(2013) Robert S. Balaban   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels

(2013) Fahmeed Hyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5+ liver stem cells, hepatic organoids and regenerative medicine

(2013) Meritxell Huch et al.   Regenerative Medicine

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Biomarkers and biosensors for the early diagnosis of lung cancer

(2013) Zeynep Altintas et al.   SENSORS AND ACTUATORS B-CHEMICAL

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels

(2013) Harish Shankaran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

Microphysiological systems and low-cost microfluidic platform with analytics

(2013) Alec ST Smith et al.   Stem Cell Research & Therapy

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development

(2013) Anurag Mathur et al.   Stem Cell Research & Therapy

Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes

(2013) Adam W. Feinberg et al.   Stem Cell Reports

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

Characterizing the Kinetics of Nanoparticle-Catalyzed Reactions by Surface-Enhanced Raman Scattering

(2012) Virginia Joseph et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modeling Life

(2012) Michael L. Shuler   ANNALS OF BIOMEDICAL ENGINEERING

Engineering microscale topographies to control the cell–substrate interface

(2012) Mehdi Nikkhah et al.   BIOMATERIALS

Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions

(2012) Masumi Yamada et al.   BIOMATERIALS

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships

(2012) Xiaoyan A Qu et al.   BMC BIOINFORMATICS

Quantitativein vitrotoin vivoextrapolation of cell-based toxicity assay results

(2012) Miyoung Yoon et al.   CRITICAL REVIEWS IN TOXICOLOGY

Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients

(2012) Limor Zwi-Dantsis et al.   EUROPEAN HEART JOURNAL

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

(2012) Albert J. Keung et al.   Integrative Biology

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Evaluation of gastrointestinal drug supersaturation and precipitation: Strategies and issues

(2012) Jan Bevernage et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In Vivo Maturation of Functional Renal Organoids Formed from Embryonic Cell Suspensions

(2012) C. Xinaris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Optofluidic devices and applications in photonics, sensing and imaging

(2012) Lin Pang et al.   LAB ON A CHIP

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

(2012) Dmitry A. Markov et al.   LAB ON A CHIP

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Optofluidic detection for cellular phenotyping

(2012) Yi-Chung Tung et al.   LAB ON A CHIP

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils

(2012) Sewoon Han et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging

(2012) Serap Altay Arpali et al.   LAB ON A CHIP

Optical imaging techniques in microfluidics and their applications

(2012) Jigang Wu et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Optofluidic imaging: now and beyond

(2012) Yanhui Zhao et al.   LAB ON A CHIP

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells

(2012) Elisa Cimetta et al.   LAB ON A CHIP

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

(2012) Sang-Hyug Park et al.   PLoS One

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips

(2012) Leila Choucha Snouber et al.   TOXICOLOGICAL SCIENCES

Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats

(2012) Yohsuke Minowa et al.   TOXICOLOGY

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

Differentiation of Embryonic Stem Cells into Cardiomyocytes in a Compliant Microfluidic System

(2011) Chen-rei Wan et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The value of in silico chemistry in the safety assessment of chemicals in the consumer goods and pharmaceutical industries

(2011) Sandeep Modi et al.   DRUG DISCOVERY TODAY

(Micro)managing the mechanical microenvironment

(2011) Christopher Moraes et al.   Integrative Biology

Synthesis of Bifunctional Au/Pt/Au Core/Shell Nanoraspberries for in Situ SERS Monitoring of Platinum-Catalyzed Reactions

(2011) Wei Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Field-portable lensfree tomographic microscope

(2011) Serhan O. Isikman et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

(2011) Kazuo Takayama et al.   MOLECULAR THERAPY

A Multifunctional 3D Co-Culture System for Studies of Mammary Tissue Morphogenesis and Stem Cell Biology

(2011) Jonathan J. Campbell et al.   PLoS One

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

(2011) María-Isabel Rocha-Gaso et al.   SENSORS

Fabrication of Two-Layered Channel System with Embedded Electrodes to Measure Resistance Across Epithelial and Endothelial Barriers

(2010) Nicholas J. Douville et al.   ANALYTICAL CHEMISTRY

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Murine in vitro model of the blood–brain barrier for evaluating drug transport

(2010) Gilda Shayan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

(2010) Olivier Toussaint et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling

(2010) Elisa Cimetta et al.   LAB ON A CHIP

A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening

(2010) Varun Trivedi et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

High-throughput fluorescence detection using an integrated zone-plate array

(2010) Ethan Schonbrun et al.   LAB ON A CHIP

Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications

(2010) Onur Mudanyali et al.   LAB ON A CHIP

Microfluidic cell culture systems for drug research

(2010) Min-Hsien Wu et al.   LAB ON A CHIP

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

(2010) Mazher-Iqbal Mohammed et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Effects of surface density and size of gold nanoparticles in a fiber-optic localized surface plasmon resonance sensor and its application to peptide detection

(2010) Hun Lee et al.   MEASUREMENT SCIENCE and TECHNOLOGY

Fast, high-contrast imaging of animal development with scanned light sheet–based structured-illumination microscopy

(2010) Philipp J Keller et al.   NATURE METHODS

Lensless wide-field fluorescent imaging on a chip using compressive decoding of sparse objects

(2010) Ahmet F. Coskun et al.   OPTICS EXPRESS

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

(2010) Yuxia Cui et al.   PHARMACOGENOMICS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks

(2010) Joel T. Dudley et al.   Journal of Cardiovascular Translational Research

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

High throughput methods applied in biomaterial development and discovery

(2009) Andrew L. Hook et al.   BIOMATERIALS

Design and testing of a packaged microfluidic cell for the multiplexed electrochemical detection of cancer markers

(2009) Olivier Yves Henry et al.   ELECTROPHORESIS

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

(2009) Jianbo Shao et al.   LAB ON A CHIP

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

(2009) Shannon L. Faley et al.   LAB ON A CHIP

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

A Pathway-Based View of Human Diseases and Disease Relationships

(2009) Yong Li et al.   PLoS One

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Differentiation of Neural Progenitor Cells in a Microfluidic Chip-Generated Cytokine Gradient

(2009) Joong Yull Park et al.   STEM CELLS

In silico toxicology for the pharmaceutical sciences☆

(2009) Luis G. Valerio Jr.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

(2009) Richard D. Beger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology

Surface acoustic wave biosensors: a review

(2008) Kerstin Länge et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants

(2008) Lingkang Huang et al.   BMC GENOMICS

SERS—a single-molecule and nanoscale tool for bioanalytics

(2008) Janina Kneipp et al.   CHEMICAL SOCIETY REVIEWS

Single-cell-based image analysis of high-throughput cell array screens for quantification of viral infection

(2008) Petr Matula et al.   CYTOMETRY PART A

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

Large-scale prediction of drug-target relationships

(2008) Michael Kuhn et al.   FEBS LETTERS

Observing Metal-Catalyzed Chemical Reactions in Situ Using Surface-Enhanced Raman Spectroscopy on Pd−Au Nanoshells

(2008) Kimberly N. Heck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessing chronic liver toxicity based on relative gene expression data

(2008) Kedar Kulkarni et al.   JOURNAL OF THEORETICAL BIOLOGY

Microfluidic assembly blocks

(2008) Minsoung Rhee et al.   LAB ON A CHIP

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

Development of a FPW allergy biosensor for human IgE detection by MEMS and cystamine-based SAM technologies

(2008) I.-Y. Huang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Engineered Microenvironments for Controlled Stem Cell Differentiation

(2008) Jason A. Burdick et al.   TISSUE ENGINEERING PART A

Electrochemical Glucose Biosensors

(2007) Joseph Wang   CHEMICAL REVIEWS

A microfluidic processor for gene expression profiling of single human embryonic stem cells

(2007) Jiang F. Zhong et al.   LAB ON A CHIP