Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Lung tissue engineering

(2014) David et al.   Frontiers in Bioscience-Landmark

Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines

(2014) Thibault Bricks et al.   TOXICOLOGY IN VITRO

Investigation of expression and activity levels of primary rat hepatocyte detoxication genes under various flow rates and cell densities in microfluidic biochips

(2013) Régis Baudoin et al.   BIOTECHNOLOGY PROGRESS

A review of the toxicology and pathology of the gastrointestinal tract

(2013) G. R. Betton   CELL BIOLOGY AND TOXICOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips

(2013) Audrey Legendre et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Models to Predict Intestinal Absorption of Therapeutic Peptides and Proteins

(2012) Filipa Antunes et al.   CURRENT DRUG METABOLISM

Prediction of the human oral bioavailability by using in vitro and in silico drug related parameters in a physiologically based absorption model

(2012) Paulo Paixão et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Parallelized microfluidic biochips in multi well plate applied to liver tissue engineering

(2012) Régis Baudoin et al.   SENSORS AND ACTUATORS B-CHEMICAL

New perspectives on neuronal development via microfluidic environments

(2012) Larry J. Millet et al.   TRENDS IN NEUROSCIENCES

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

(2012) Régis Baudoin et al.   XENOBIOTICA

Loss of orally administered drugs in GI tract

(2012) Yogeshkumar Nanasaheb Gavhane et al.   SAUDI PHARMACEUTICAL JOURNAL

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

(2012) Donglu Zhang et al.   Acta Pharmaceutica Sinica B

Improvement of HepG2/C3a cell functions in a microfluidic biochip

(2011) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells

(2010) Nicholas Ferrell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

(2010) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

GNU MCSim: Bayesian statistical inference for SBML-coded systems biology models

(2009) F. Y. Bois   BIOINFORMATICS

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Intestinal First-Pass Metabolism of CYP3A4 Substrates

(2008) Motohiro Kato   Drug Metabolism and Pharmacokinetics

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS