Microfabrication of human organs-on-chips

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Clear castable polyurethane elastomer for fabrication of microfluidic devices

(2013) Karel Domansky et al.   LAB ON A CHIP

Simple replica micromolding of biocompatible styrenic elastomers

(2013) Mark D. Borysiak et al.   LAB ON A CHIP

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

(2013) M. L. McCain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Multi-compartment neuron–glia co-culture platform for localized CNS axon–glia interaction study

(2012) Jaewon Park et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

A tissue-engineered jellyfish with biomimetic propulsion

(2012) Janna C Nawroth et al.   NATURE BIOTECHNOLOGY

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

(2011) Ioannis K. Zervantonakis et al.   Biomicrofluidics

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Biocompatibility and Reduced Drug Absorption of Sol−Gel-Treated Poly(dimethyl siloxane) for Microfluidic Cell Culture Applications

(2010) Rafael Gomez-Sjoberg et al.   ANALYTICAL CHEMISTRY

Microfluidic Cardiac Cell Culture Model (μCCCM)

(2010) Guruprasad A. Giridharan et al.   ANALYTICAL CHEMISTRY

Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes

(2010) Lin Wang et al.   BIOMATERIALS

Mucin (MUC5AC) expression by lung epithelial cells cultured in a microfluidic gradient device

(2010) Su Hwan Kim et al.   ELECTROPHORESIS

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

(2010) Yu-suke Torisawa et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

(2010) Kyung-Jin Jang et al.   Integrative Biology

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Measurement of Contractile Stress Generated by Cultured Rat Muscle on Silicon Cantilevers for Toxin Detection and Muscle Performance Enhancement

(2010) Kerry Wilson et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices

(2009) Kyung Eun Sung et al.   BIOMATERIALS

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

(2009) Christopher M. Puleo et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP