Blood–brain barrier structure and function and the challenges for CNS drug delivery

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases

(2012) Rosella Tomanin et al.   ACTA PAEDIATRICA

Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease

(2012) Einat B. Vitner et al.   BRAIN

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity

(2012) Omolara O. Ogunshola   CURRENT PHARMACEUTICAL DESIGN

Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

(2012) Henna Ylikangas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-Aβ-MAb and dually decorated nanoliposomes: Effect of Aβ1-42 peptides on interaction with hCMEC/D3 cells

(2012) Eleni Markoutsa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

(2012) Arjun Saha et al.   HUMAN MOLECULAR GENETICS

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

(2012) Danica B Stanimirovic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Delivery of drugs to the brain via the blood brain barrier using colloidal carriers

(2012) Ian G. Tucker et al.   JOURNAL OF MICROENCAPSULATION

Synthetic genistein derivatives as modulators of glycosaminoglycan storage

(2012) Anna Kloska et al.   Journal of Translational Medicine

Relocalization of Junctional Adhesion Molecule A during Inflammatory Stimulation of Brain Endothelial Cells

(2012) S. M. Stamatovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Sialic Acid Deposition Impairs the Utility of AAV9, but Not Peptide-modified AAVs for Brain Gene Therapy in a Mouse Model of Lysosomal Storage Disease

(2012) Yong Hong Chen et al.   MOLECULAR THERAPY

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach

(2012) Shane A. Liddelow et al.   PLoS One

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

(2012) Pericles Calias et al.   PLoS One

Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier

(2012) Shinya Dohgu et al.   PLoS One

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease

(2012) Mario A. Cabrera-Salazar et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Barrier Mechanisms in the Developing Brain

(2012) Norman R. Saunders et al.   Frontiers in Pharmacology

Identification of Proline Residues in or near the Transmembrane Helices of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) That Are Important for Transport Activity and Substrate Specificity

(2011) Zhanglin Ni et al.   BIOCHEMISTRY

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases

(2011) Chaitali Ghosh et al.   CURRENT DRUG METABOLISM

Therapies for Neurological Disease in the Mucopolysaccharidoses

(2011) Donald S. Anson et al.   CURRENT GENE THERAPY

Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes

(2011) Elodie Vandenhaute et al.   CURRENT NEUROVASCULAR RESEARCH

Intrathecal Enzyme Replacement Therapy for Mucopolysaccharidosis I: Translating Success in Animal Models to Patients

(2011) Patricia I. Dickson et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

(2011) Luca Costantino et al.   DRUG DISCOVERY TODAY

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood–brain barrier permeability?

(2011) Alex Avdeef   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy

(2011) S. Stroobants et al.   HUMAN MOLECULAR GENETICS

Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease

(2011) T. Farfel-Becker et al.   HUMAN MOLECULAR GENETICS

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage

(2011) Gokulan Thanabalasundaram et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transport of Arylsulfatase A across the Blood-Brain Barrierin Vitro

(2011) Frank Matthes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Miglustat Treatment in Patients with Type III Mucopolysaccharidosis: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Nathalie Guffon et al.   JOURNAL OF PEDIATRICS

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: The positive effect of long-term aspirin treatment

(2011) Audrey Arfi et al.   MOLECULAR GENETICS AND METABOLISM

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Correction of Neurological Disease of Mucopolysaccharidosis IIIB in Adult Mice by rAAV9 Trans-Blood–Brain Barrier Gene Delivery

(2011) Haiyan Fu et al.   MOLECULAR THERAPY

Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood–brain barrier

(2011) Giovanni Tosi et al.   Nanomedicine

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Circumventricular organs: Receptive and homeostatic functions and clinical implications

(2011) E. E. Benarroch   NEUROLOGY

Blood-Brain Barrier Impairment in an Animal Model of MPS III B

(2011) Svitlana Garbuzova-Davis et al.   PLoS One

Predicting P-Glycoprotein-Mediated Drug Transport Based On Support Vector Machine and Three-Dimensional Crystal Structure of P-glycoprotein

(2011) Zsolt Bikadi et al.   PLoS One

Clarifying lysosomal storage diseases

(2011) Mark L. Schultz et al.   TRENDS IN NEUROSCIENCES

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model

(2010) I. Visigalli et al.   BLOOD

Diphtheria Toxin Mutant CRM197-Mediated Transcytosis across Blood–Brain Barrier In Vitro

(2010) Ping Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

(2010) Eleni Markoutsa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

(2010) Fabien Dutheil et al.   Expert Opinion on Drug Metabolism & Toxicology

Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases

(2010) Einat B. Vitner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lessons learnt from animal models: pathophysiology of neuropathic lysosomal storage disorders

(2010) Kim M. Hemsley et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Pathophysiology of neuropathic lysosomal storage disorders

(2010) Cinzia Maria Bellettato et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Therapeutic approaches for neuronopathic lysosomal storage disorders

(2010) Raphael Schiffmann   JOURNAL OF INHERITED METABOLIC DISEASE

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

(2010) Smruti Killedar et al.   Journal of Neuroinflammation

Trans-generational exposure to low levels of rhodamine B does not adversely affect litter size or liver function in murine mucopolysaccharidosis type IIIA

(2010) Ainslie L.K. Roberts et al.   MOLECULAR GENETICS AND METABOLISM

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Intracisternal enzyme replacement therapy in lysosomal storage diseases: routes of absorption into brain

(2010) R. D. Jolly et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model

(2010) Oksana Tsinman et al.   PHARMACEUTICAL RESEARCH

Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease

(2010) Marcelina Malinowska et al.   PLoS One

New Strategies for Enzyme Replacement Therapy for Lysosomal Storage Diseases

(2010) Jeffrey H. Grubb et al.   REJUVENATION RESEARCH

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Will the original glucose transporter isoform please stand up!

(2009) Anthony Carruthers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transport of interleukin-1 across cerebromicrovascular endothelial cells

(2009) RA Skinner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept

(2009) Andreas Reichel   CHEMISTRY & BIODIVERSITY

P-glycoprotein deficient mouse in situ blood–brain barrier permeability and its prediction using an in combo PAMPA model

(2009) Claude Dagenais et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enzyme Replacement Improves Ataxic Gait and Central Nervous System Histopathology in a Mouse Model of Metachromatic Leukodystrophy

(2009) Ulrich Matzner et al.   MOLECULAR THERAPY

The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

(2009) Dries Vercauteren et al.   MOLECULAR THERAPY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Substrate reduction therapy

(2008) Frances M Platt et al.   ACTA PAEDIATRICA

Endothelial transcytosis in health and disease

(2008) Maya Simionescu et al.   CELL AND TISSUE RESEARCH

A combined artificial chromosome-stem cell therapy method in a model experiment aimed at the treatment of Krabbe’s disease in the Twitcher mouse

(2008) R. L. Katona et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Assays to Predict Drug Permeation Across the Blood-Brain Barrier, and Distribution to Brain

(2008) N. Abbott et al.   CURRENT DRUG METABOLISM

Lysosomal Storage Diseases and the Blood-Brain Barrier

(2008) David Begley et al.   CURRENT PHARMACEUTICAL DESIGN

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

(2008) Pietra Candela et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

(2008) Sandrine Dauchy et al.   JOURNAL OF NEUROCHEMISTRY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

Chemically modified  -glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII

(2008) J. H. Grubb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human ABC transporters ABCG2 (BCRP) and ABCG4

(2008) S. Koshiba et al.   XENOBIOTICA