Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

Biology coming full circle: Joining the whole and the parts

(2015) John P Wikswo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

(2015) Asad A. Aboud et al.   NEUROBIOLOGY OF DISEASE

Enhanced Neurite Outgrowth of Human Model (NT2) Neurons by Small-Molecule Inhibitors of Rho/ROCK Signaling

(2015) Frank Roloff et al.   PLoS One

Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model

(2014) R. Booth et al.   ANNALS OF BIOMEDICAL ENGINEERING

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

(2014) Danica B Stanimirovic et al.   Expert Opinion on Drug Discovery

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

(2014) Andrew M. Tidball et al.   HUMAN MOLECULAR GENETICS

Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood–brain barrier

(2014) Zhizhi Sun et al.   International Journal of Nanomedicine

An in vitro blood–brain barrier model combining shear stress and endothelial cell/astrocyte co-culture

(2014) Yukio Takeshita et al.   JOURNAL OF NEUROSCIENCE METHODS

Neurotrophic Requirements of Human Motor Neurons Defined Using Amplified and Purified Stem Cell-Derived Cultures

(2014) Nuno Jorge Lamas et al.   PLoS One

A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box

(2013) Luca Cucullo et al.   BMC NEUROSCIENCE

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

In vitro Permeability Study of CNS-Active Diterpenes from Sideritis spp. Using Cellular Models of Blood-Brain Barrier

(2013) Elena González-Burgos et al.   PLANTA MEDICA

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

(2013) Xin Tang et al.   Stem Cell Research

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening

(2013) C Boissart et al.   Translational Psychiatry

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Hurdles with Using In Vitro Models to Predict Human Blood-brain Barrier Drug Permeability: A Special Focus on Transporters and Metabolizing Enzymes

(2012) Ramzi Shawahna et al.   CURRENT DRUG METABOLISM

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microfabricated scaffold-guided endothelial morphogenesis in three-dimensional culture

(2011) Yuxin Liu et al.   BIOMEDICAL MICRODEVICES

Electrical impedance spectroscopy measurements using a four-electrode configuration improve on-line monitoring of cell concentration in adherent animal cell cultures

(2011) E. Sarró et al.   BIOSENSORS & BIOELECTRONICS

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes

(2011) Elodie Vandenhaute et al.   CURRENT NEUROVASCULAR RESEARCH

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

Case study: adapting in vitro blood–brain barrier models for use in early-stage drug discovery

(2011) Elodie Vandenhaute et al.   DRUG DISCOVERY TODAY

Stabilization of brain microvascular endothelial barrier function by shear stress involves VE-cadherin signaling leading to modulation of pTyr-occludin levels

(2011) Tony G. Walsh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

(2011) Kathryn Hatherell et al.   JOURNAL OF NEUROSCIENCE METHODS

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier

(2011) Fumitaka Shimizu et al.   NEUROCHEMICAL RESEARCH

Co-culture Based Blood-brain Barrier In Vitro Model, a Tissue Engineering Approach using Immortalized Cell Lines for Drug Transport Study

(2010) Zhiqi Zhang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Ascorbic acid prevents increased endothelial permeability caused by oxidized low density lipoprotein

(2010) James M. May et al.   FREE RADICAL RESEARCH

Astrocytes and Pericytes Differentially Modulate Blood—Brain Barrier Characteristics during Development and Hypoxic Insult

(2010) Abraham Al Ahmad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices

(2010) Kiana Aran et al.   LAB ON A CHIP

High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)–Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations

(2010) Angelika Hoffmann et al.   Translational Stroke Research

Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation

(2009) James M. May et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL