Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

Determination of cell metabolite VEGF 165 and dynamic analysis of protein–DNA interactions by combination of microfluidic technique and luminescent switch-on probe

(2016) Xuexia Lin et al.   BIOSENSORS & BIOELECTRONICS

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes – D4 and D5

(2016) Tami S. McMullin et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In Vitro Skin Models and Their Predictability in Defining Normal and Disease Biology, Pharmacology, and Toxicity

(2016) Dimitry M. Danilenko et al.   TOXICOLOGIC PATHOLOGY

Textile Technologies and Tissue Engineering: A Path Toward Organ Weaving

(2016) Mohsen Akbari et al.   Advanced Healthcare Materials

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

In vitro micro-physiological models for translational immunology

(2015) Qasem Ramadan et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

In vitro 3-D model based on extending time of culture for studying chronological epidermis aging

(2015) Morgan Dos Santos et al.   MATRIX BIOLOGY

Functional differentiation of human pluripotent stem cells on a chip

(2015) Giovanni G Giobbe et al.   NATURE METHODS

Programmed synthesis of three-dimensional tissues

(2015) Michael E Todhunter et al.   NATURE METHODS

News Feature: Building benchtop human models

(2015) Amber Dance   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of skin models in drug development

(2014) Stephanie H. Mathes et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered three-dimensional microfluidic device for interrogating cell-cell interactions in the tumor microenvironment

(2014) K. Hockemeyer et al.   Biomicrofluidics

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

Thermoresponsive chitosan–agarose hydrogel for skin regeneration

(2014) Sónia P. Miguel et al.   CARBOHYDRATE POLYMERS

Challenges and promises in modeling dermatologic disorders with bioengineered skin

(2014) Narat J Eungdamrong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Development of Artificial Dermis Using 3D Electrospun Silk Fibroin Nanofiber Matrix

(2014) Ok Joo Lee et al.   Journal of Biomedical Nanotechnology

Lymphocyte Electrotaxis In Vitro and In Vivo

(2014) F. Lin et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type

(2014) M. Sasaki et al.   JOURNAL OF IMMUNOLOGY

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

A Glycosaminoglycan Based, Modular Tissue Scaffold System for Rapid Assembly of Perfusable, High Cell Density, Engineered Tissues

(2014) Ramkumar Tiruvannamalai-Annamalai et al.   PLoS One

A novel microfluidic wound model for testing antimicrobial agents against Staphylococcus pseudintermedius biofilms

(2014) Jacob Terry et al.   JOURNAL OF NANOBIOTECHNOLOGY

Silk fibroin/chondroitin sulfate/hyaluronic acid ternary scaffolds for dermal tissue reconstruction

(2013) Shuqin Yan et al.   Acta Biomaterialia

25th Anniversary Article: Engineering Hydrogels for Biofabrication

(2013) Jos Malda et al.   ADVANCED MATERIALS

Type I collagen and polyvinyl alcohol blend fiber scaffold for anterior cruciate ligament reconstruction

(2013) Changbin Cai et al.   Biomedical Materials

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Anin vitroskin model to study the effect of mesenchymal stem cells in wound healing and epidermal regeneration

(2013) Nkemcho O. Ojeh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Chitosan scaffold co-cultured with keratinocyte and fibroblast heals full thickness skin wounds in rabbit

(2013) Deepa Revi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Artificial microfluidic skin for in vitro perspiration simulation and testing

(2013) Linlin Hou et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Direct laser writing of sub-50 nm nanofluidic channels buried in glass for three-dimensional micro-nanofluidic integration

(2013) Yang Liao et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Surface modification of nanofibrous polycaprolactone/gelatin composite scaffold by collagen type I grafting for skin tissue engineering

(2013) Sneh Gautam et al.   Materials Science & Engineering C-Materials for Biological Applications

Advanced biofabrication strategies for skin regeneration and repair

(2013) Rúben F Pereira et al.   Nanomedicine

Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation

(2013) Thomas Biedermann et al.   PEDIATRIC SURGERY INTERNATIONAL

Tissue Engineered Skin Substitutes Created by Laser-Assisted Bioprinting Form Skin-Like Structures in the Dorsal Skin Fold Chamber in Mice

(2013) Stefanie Michael et al.   PLoS One

Design and Fabrication of Human Skin by Three-Dimensional Bioprinting

(2013) Vivian Lee et al.   TISSUE ENGINEERING PART C-METHODS

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Building a microphysiological skin model from induced pluripotent stem cells

(2013) Zongyou Guo et al.   Stem Cell Research & Therapy

Acne vulgaris

(2013) A. L. Dawson et al.   BMJ-British Medical Journal

Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

(2013) Mathieu Blais et al.   Stem Cells Translational Medicine

Modeling the human skin barrier — Towards a better understanding of dermal absorption

(2012) Owen G. Jepps et al.   ADVANCED DRUG DELIVERY REVIEWS

Electrospun nanostructured chitosan–poly(vinyl alcohol) scaffolds: a biomimetic extracellular matrix as dermal substitute

(2012) Dhakshinamoorthy Sundaramurthi et al.   Biomedical Materials

Microfluidic device for studying cell migration in single or co-existing chemical gradients and electric fields

(2012) Jing Li et al.   Biomicrofluidics

Skin tissue generation by laser cell printing

(2012) Lothar Koch et al.   BIOTECHNOLOGY AND BIOENGINEERING

A systematic review of worldwide incidence of nonmelanoma skin cancer

(2012) A. Lomas et al.   BRITISH JOURNAL OF DERMATOLOGY

Epidemiology of acne vulgaris

(2012) K. Bhate et al.   BRITISH JOURNAL OF DERMATOLOGY

Nature versus nurture: does human skin maintain its stratum corneum lipid propertiesin vitro?

(2012) Varsha S. Thakoersing et al.   EXPERIMENTAL DERMATOLOGY

Epidermal morphogenesis during progressivein vitro3D reconstruction at the air-liquid interface

(2012) Aurélie Frankart et al.   EXPERIMENTAL DERMATOLOGY

Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

(2012) Sari Pappinen et al.   JOURNAL OF CONTROLLED RELEASE

Fabrication and characterization of poly(l-lactide-co-glycolide) knitted mesh-reinforced collagen–chitosan hybrid scaffolds for dermal tissue engineering

(2012) Xingang Wang et al.   Journal of the Mechanical Behavior of Biomedical Materials

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Facile fabrication of the glutaraldehyde cross-linked collagen/chitosan porous scaffold for skin tissue engineering

(2012) Yunyun Liu et al.   Materials Science & Engineering C-Materials for Biological Applications

Microfluidic Approaches to Bacterial Biofilm Formation

(2012) Junghyun Kim et al.   MOLECULES

Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation?

(2012) Thomas Biedermann et al.   PEDIATRIC SURGERY INTERNATIONAL

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering

(2012) Witoo Luangbudnark et al.   TheScientificWorldJOURNAL

Human Skin Model Containing Melanocytes: Essential Role of Keratinocyte Growth Factor for Constitutive Pigmentation—Functional Response to α-Melanocyte Stimulating Hormone and Forskolin

(2012) Christine Duval et al.   TISSUE ENGINEERING PART C-METHODS

Epidemiology and Economic Burden of Nonmelanoma Skin Cancer

(2012) Burak Ömür Cakir et al.   Facial Plastic Surgery Clinics of North America

Skin tissue engineering — In vivo and in vitro applications

(2011) Florian Groeber et al.   ADVANCED DRUG DELIVERY REVIEWS

Differentiation of human umbilical cord mesenchymal stem cells into dermal fibroblasts in vitro

(2011) Yanfu Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A receptor-electromigration-based model for cellular electrotactic sensing and migration

(2011) Dan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Fibers for Skin Tissue Engineering: Effects of Topography, Mechanical, and Chemical Stimuli

(2011) Purushothaman Kuppan et al.   BIOMACROMOLECULES

Induction of putative stratified epithelial progenitor cells in vitro from mouse-induced pluripotent stem cells

(2011) Miharu Sakurai et al.   JOURNAL OF ARTIFICIAL ORGANS

Fabrication and biocompatibility of novel bilayer scaffold for skin tissue engineering applications

(2011) Rose Ann Franco et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin

(2011) Vicky Gagnon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration

(2011) Krista Ouwehand et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preparation and characterization of electrospun PCL/PLGA membranes and chitosan/gelatin hydrogels for skin bioengineering applications

(2011) Rose Ann Franco et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Adipose-derived stem cells (ASCs) as a source of endothelial cells in the reconstruction of endothelialized skin equivalents

(2011) C. Auxenfans et al.   Journal of Tissue Engineering and Regenerative Medicine

Molecular aspects of skin ageing

(2011) Elizabeth C. Naylor et al.   MATURITAS

Additive manufacturing of tissues and organs

(2011) Ferry P.W. Melchels et al.   PROGRESS IN POLYMER SCIENCE

Cell patterning technologies for organotypic tissue fabrication

(2011) Bertrand Guillotin et al.   TRENDS IN BIOTECHNOLOGY

Microfluidic devices for studying chemotaxis and electrotaxis

(2011) Jing Li et al.   TRENDS IN CELL BIOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Bioprinting of hybrid tissue constructs with tailorable mechanical properties

(2011) W Schuurman et al.   Biofabrication

Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies

(2010) Shiow-Fern Ng et al.   AAPS PHARMSCITECH

Langerhans cells as targets for immunotherapy against skin cancer

(2010) Patrizia Stoitzner et al.   IMMUNOLOGY AND CELL BIOLOGY

Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

(2010) Ganna Bilousova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin regeneration and repair

(2010) Cédric Blanpain   NATURE

Nanotechnological strategies for engineering complex tissues

(2010) Tal Dvir et al.   Nature Nanotechnology

Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells

(2010) Shulamit Levenberg et al.   Nature Protocols

An Overview of Methods for the In Vivo Evaluation of Tissue-Engineered Skin Constructs

(2010) Gerwen Lammers et al.   TISSUE ENGINEERING PART B-REVIEWS

Functional Neovascularization in Tissue Engineering with Porcine Acellular Dermal Matrix and Human Umbilical Vein Endothelial Cells

(2010) Xiaojun Zhang et al.   TISSUE ENGINEERING PART C-METHODS

Epidermal stem cells: practical perspectives and potential uses

(2009) O. Abbas et al.   BRITISH JOURNAL OF DERMATOLOGY

Improvement of Nerve Regeneration in Tissue-Engineered Skin Enriched with Schwann Cells

(2009) Mathieu Blais et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

(2009) Hind Guenou et al.   LANCET

A catch-up validation study on reconstructed human epidermis (SkinEthic™ RHE) for full replacement of the Draize skin irritation test

(2009) Nathalie Alépée et al.   TOXICOLOGY IN VITRO

Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms

(2008) Joung-Hyun Lee et al.   BIOMEDICAL MICRODEVICES

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

Microbial colonization of anin vitromodel of a tissue engineered human skin equivalent – a novel approach

(2008) Diana B. Holland et al.   FEMS MICROBIOLOGY LETTERS

Differentiation of Human Embryonic Stem Cells on Periodontal Ligament Fibroblasts In Vitro

(2007) Bülend Inanç et al.   ARTIFICIAL ORGANS

Culturing adult human bone marrow stem cells on gelatin scaffold with pNIPAAm as transplanted grafts for skin regeneration

(2007) Cherng-Kang Perng et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS