Amyloid-beta and tau protein beyond Alzheimer’s disease

Cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in tremor-dominant Parkinson’s disease

(2023) Fardin Nabizadeh et al.   ACTA NEUROLOGICA BELGICA

Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

(2023) Andrew Siderowf et al.   LANCET NEUROLOGY

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

(2023) Constanze Depp et al.   NATURE

Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells

(2023) Liting Deng et al.   Proteomes

The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases

(2022) Sina Shadfar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease

(2022) Morteza Abyadeh et al.   Cells

Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks

(2022) Mehdi Mirzaei et al.   PROTEOMICS

CSF p-tau as a potential cognition impairment biomarker in ALS

(2022) Zhongying Gong et al.   Frontiers in Neurology

Increased β‐site APP cleaving enzyme 1‐mediated insulin receptor cleavage in type 2 diabetes mellitus with cognitive impairment

(2021) Hong Bao et al.   Alzheimers & Dementia

Tau in the Pathophysiology of Parkinson’s Disease

(2021) Lina Pan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications

(2021) Liang Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Different Aggregation Pathways and Structures for Aβ40 and Aβ42 Peptides

(2021) Li Wang et al.   Biomolecules

5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition

(2021) Chinmayee Sethy et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

(2021) Anastasie Maté de Gérando et al.   BRAIN

Mitochondrial dysfunction in Alzheimer’s disease - a proteomics perspective

(2021) Morteza Abyadeh et al.   Expert Review of Proteomics

Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

(2021) Maojun Yao et al.   Food Science and Human Wellness

Cellular and pathological heterogeneity of primary tauopathies

(2021) Dah-eun Chloe Chung et al.   Molecular Neurodegeneration

Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway

(2021) Shira Mencer et al.   Translational Psychiatry

Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

(2021) Aurélie Ledreux et al.   Journal of Clinical Medicine

Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

(2021) Nitin Chitranshi et al.   Cells

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

(2021) Ying Tian et al.   Nature Biomedical Engineering

Distinct phosphorylation profiles of tau in brains of patients with different tauopathies

(2021) Nastaran Samimi et al.   NEUROBIOLOGY OF AGING

Distributions of Aβ42 and Aβ42/40 in the Cerebrospinal Fluid in View of the Probability Theory

(2021) Piotr Lewczuk et al.   Diagnostics

Association of plasma β-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults

(2020) Xiaobo Peng et al.   DIABETOLOGIA

Myocardial Infarction Predisposes Neurodegenerative Diseases

(2020) Wei Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

(2020) Dimitrios A. Stakos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies

(2020) Jonathan Chang-Cheng Shieh et al.   MOLECULAR NEUROBIOLOGY

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

(2020) Janett Köppen et al.   MOLECULES

Tau Reduction Prevents Key Features of Autism in Mouse Models

(2020) Chao Tai et al.   NEURON

Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report

(2020) Abbie S. Ornelas et al.   PARKINSONISM & RELATED DISORDERS

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

(2020) Matthew R. Barron et al.   Frontiers in Immunology

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway

(2020) Xiao-long Wu et al.   Journal of Zhejiang University-SCIENCE B

Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways

(2020) Cristina Lanni et al.   MOLECULAR PSYCHIATRY

Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations

(2020) Alexander M. Markin et al.   Frontiers in Pharmacology

High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders

(2020) Hamza Ayaydın et al.   Clinical Psychopharmacology and Neuroscience

Alzheimer’s Disease and Cardiovascular Disease: A Particular Association

(2020) Giacomo Tini et al.   Cardiology Research and Practice

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

(2020) Long Wang et al.   Frontiers in Cell and Developmental Biology

Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

(2020) Ji Hoon Yu et al.   Frontiers in Cell and Developmental Biology

Accumulation of amyloid beta in human glioblastomas

(2020) A. Zayas‐Santiago et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Amyotrophic lateral sclerosis: a clinical review

(2020) P. Masrori et al.   EUROPEAN JOURNAL OF NEUROLOGY

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

Tauopathy in the young autistic brain: novel biomarker and therapeutic target

(2020) Iris Grigg et al.   Translational Psychiatry

Relation of plasma β ‐amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study

(2020) José Rafael Romero et al.   Annals of Clinical and Translational Neurology

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

(2020) Gabriela Dumitrita Stanciu et al.   Journal of Clinical Medicine

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

(2020) Sathish Kumar et al.   Acta Neuropathologica Communications

Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy

(2020) Yuta Takaichi et al.   Acta Neuropathologica Communications

Retinal Degeneration and Alzheimer’s Disease: An Evolving Link

(2020) Ajay Ashok et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s disease and type 2 diabetes mellitus: A systematic review of proteomic studies

(2020) Jessica Diniz Pereira et al.   JOURNAL OF NEUROCHEMISTRY

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

(2020) Anna Konopka et al.   Molecular Neurodegeneration

Retinal ganglion cell loss and gliosis in the retinofugal projection following intravitreal exposure to amyloid-beta

(2020) E.S. Simons et al.   NEUROBIOLOGY OF DISEASE

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature

(2020) Emma Ristori et al.   Frontiers in Physiology

On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

(2020) Mikhail Inyushin et al.   Frontiers in Immunology

Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines

(2020) Philipp Spitzer et al.   Frontiers in Immunology

Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue

(2020) L. Lemoine et al.   Molecular Neurodegeneration

Targeting Tau to Treat Clinical Features of Huntington's Disease

(2020) Maria Masnata et al.   Frontiers in Neurology

Alterations in Tau Metabolism in ALS and ALS-FTSD

(2020) Michael J. Strong et al.   Frontiers in Neurology

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer

(2020) Stéphanie Papin et al.   Brain Sciences

Getting to the Heart of Alzheimer Disease

(2019) Joshua M. Tublin et al.   CIRCULATION RESEARCH

Amyloidosis of the Brain and Heart

(2019) Chris L. Schaich et al.   JACC-Heart Failure

Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells

(2019) Liting Deng et al.   Frontiers in Molecular Neuroscience

The prevalence of MS in the United States

(2019) Mitchell T. Wallin et al.   NEUROLOGY

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy

(2019) Yevgen Chornenkyy et al.   LABORATORY INVESTIGATION

Tau interacts with the C-terminal region of α-synuclein, promoting formation of toxic aggregates with distinct molecular conformations

(2019) Anvesh K. R. Dasari et al.   BIOCHEMISTRY

The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α

(2019) Xiao-Wei Zhao et al.   MOLECULAR BIOLOGY REPORTS

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

(2019) Tomoko Wakabayashi et al.   Molecular Neurodegeneration

Amyloid precursor protein and its phosphorylated form in non-small cell lung carcinoma

(2019) Shigehiro Ito et al.   PATHOLOGY RESEARCH AND PRACTICE

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

(2019) Eftychia Vasili et al.   Frontiers in Molecular Neuroscience

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease

(2019) Tracy R. Melzer et al.   Frontiers in Neurology

Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations

(2019) Leonardo Emberti Gialloreti et al.   Journal of Clinical Medicine

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

(2019) Balvindar Singh et al.   ACTA NEUROPATHOLOGICA

O-GlcNAcylation of Amyloid-β Protein Precursor by Insulin Signaling Reduces Amyloid-β Production

(2019) Oh Hoon Kwon et al.   JOURNAL OF ALZHEIMERS DISEASE

α-synuclein in the pathophysiology of Alzheimer’s disease

(2019) Daniel Twohig et al.   Molecular Neurodegeneration

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

(2019) Peng Liu et al.   Acta Neuropathologica Communications

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Prevalence of Wilson disease. An Update

(2019) Thomas Damgaard Sandahl et al.   HEPATOLOGY

Amyloid β oligomers inhibit growth of human cancer cells

(2019) Bozena Pavliukeviciene et al.   PLoS One

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Novel Functions of the Neurodegenerative-Related Gene Tau in Cancer

(2019) Ricardo Gargini et al.   Frontiers in Aging Neuroscience

Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences

(2019) Atsuko Katsumoto et al.   Frontiers in Neurology

Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

(2019) Fares Bassil et al.   NEURON

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

(2019) Romain Goulay et al.   Translational Stroke Research

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers

(2019) Pascual Sánchez-Juan et al.   Frontiers in Aging Neuroscience

Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in

(2019) Jeroen Van Schependom et al.   Translational Neurodegeneration

Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome

(2018) Kimon Stamatelopoulos et al.   ANNALS OF INTERNAL MEDICINE

Cardiovascular disease (CVD) and associated risk factors among older adults in six low-and middle-income countries: results from SAGE Wave 1

(2018) Ye Ruan et al.   BMC PUBLIC HEALTH

Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Down syndrome, beta-amyloid and neuroimaging

(2018) Elizabeth Head et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid precursor protein is overexpressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors

(2018) Dongqing Zhang et al.   INTERNATIONAL JOURNAL OF UROLOGY

Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer’s Disease

(2018) Elizabeth C. Mormino et al.   JOURNAL OF ALZHEIMERS DISEASE

Estimating the global incidence of traumatic brain injury

(2018) Michael C. Dewan et al.   JOURNAL OF NEUROSURGERY

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

(2018) Ching-Chieh Chou et al.   NATURE NEUROSCIENCE

The retina as a window to early dysfunctions of Alzheimer's disease following studies with a 5xFAD mouse model

(2018) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Pathologic Thr175tau phosphorylation in CTE and CTE with ALS

(2018) Alexander J. Moszczynski et al.   NEUROLOGY

Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J

(2018) Isabel Barón-Mendoza et al.   NEUROSCIENCE LETTERS

Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease

(2018) Rachel E. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

(2018) Paul J. Meakin et al.   Nature Communications

Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue

(2018) Sami Abu Hamdeh et al.   Scientific Reports

Cognitive Function and Ophthalmological Diseases: The Beijing Eye Study

(2018) Jost B. Jonas et al.   Scientific Reports

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease

(2018) Joseph R. Winer et al.   JAMA Neurology

Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits

(2018) Shreyasi Chatterjee et al.   Frontiers in Neuroscience

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

(2018) Paolo Raggi et al.   ATHEROSCLEROSIS

Amyloid-β-Induced Amyloid-β Secretion: A Possible Feed-Forward Mechanism in Alzheimer's Disease

(2018) Ian T. Marsden et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-Related Macular Degeneration (AMD): Alzheimer's Disease in the Eye?

(2018) Kai Kaarniranta et al.   JOURNAL OF ALZHEIMERS DISEASE

A53T mutant alpha-synuclein induces tau dependent postsynaptic impairment independent of neurodegenerative changes

(2018) Peter J. Teravskis et al.   JOURNAL OF NEUROSCIENCE

Amyloid-Beta (1-40) Peptide and Subclinical Cardiovascular Disease

(2018) Kimon Stamatelopoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction

(2018) Limor Raz et al.   NEUROBIOLOGY OF DISEASE

Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease

(2018) Cecilia S. Lee et al.   Alzheimers & Dementia

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Changes in Cerebrospinal Fluid Tau and β-Amyloid Levels in Diabetic and Prediabetic Patients: A Meta-Analysis

(2018) Yanhui Lu et al.   Frontiers in Aging Neuroscience

Multiple sclerosis

(2018) Massimo Filippi et al.   Nature Reviews Disease Primers

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer

(2018) Julia Y.S. Tsang et al.   EBioMedicine

Novel role of APP cleavage by ADAM10 for breast cancer metastasis

(2018) Justyna Wozniak et al.   EBioMedicine

Vascular ageing: Underlying mechanisms and clinical implications

(2017) Ageliki Laina et al.   EXPERIMENTAL GERONTOLOGY

Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau

(2017) Ashenafi H. Betrie et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Cancer History with Alzheimer’s Disease Dementia and Neuropathology

(2017) Mark Yarchoan et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral Amyloid Angiopathy

(2017) Christopher V. DeSimone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Edaravone for treatment of early-stage ALS

(2017) Jesús S Mora   LANCET NEUROLOGY

Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau

(2017) Keith A. Josephs   MAYO CLINIC PROCEEDINGS

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

(2017) D. Lana et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Changes of cerebrospinal fluid Aβ42, t-tau, and p-tau in Parkinson’s disease patients with cognitive impairment relative to those with normal cognition: a meta-analysis

(2017) Xiaohui Hu et al.   NEUROLOGICAL SCIENCES

MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy

(2017) Andreas Charidimou et al.   NEUROLOGY

Amelioration of amyloid β-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-κB signaling and NLRP3 inflammasome

(2017) Chunyan Lei et al.   NEUROSCIENCE

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

(2017) Onder Albayram et al.   Nature Communications

High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction

(2017) Jing Wu et al.   Oncotarget

Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer’s Disease

(2017) Ni-Chung Lee et al.   Frontiers in Aging Neuroscience

Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings

(2017) Nathan Palmer et al.   JAMA Pediatrics

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased levels of plasma total tau in adult Down syndrome

(2017) Takashi Kasai et al.   PLoS One

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

(2017) Tuhina Prasad et al.   Scientific Reports

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

(2017) Xiaomin Yin et al.   Scientific Reports

Is Huntington's disease a tauopathy?

(2016) Maud Gratuze et al.   BRAIN

TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia

(2016) Bryan D. James et al.   BRAIN

Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases

(2016) Joel Ramirez et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

Association of Plasma Aβ40 Peptides, But Not Aβ42, with Coronary Artery Disease and Diabetes Mellitus

(2016) Benjamin Roeben et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury

(2016) Sandra A. Acosta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma

(2016) M. Chiasseu et al.   JOURNAL OF NEUROSCIENCE

Purification of α-synuclein containing inclusions from human post mortem brain tissue

(2016) A. McCormack et al.   JOURNAL OF NEUROSCIENCE METHODS

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

(2016) Luca Troncone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Neurotoxic Tau45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects

(2016) Claudia R Vintilescu et al.   MOLECULAR MEDICINE

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

(2016) LI CHEN et al.   Molecular Medicine Reports

CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis

(2016) Anna M Pietroboni et al.   Multiple Sclerosis Journal

Variants in GBA , SNCA , and MAPT influence Parkinson disease risk, age at onset, and progression

(2016) Albert A. Davis et al.   NEUROBIOLOGY OF AGING

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

(2016) Ying Jiang et al.   NEUROBIOLOGY OF AGING

Creutzfeldt-Jakob disease

(2016) Yasushi Iwasaki   NEUROPATHOLOGY

Cerebral amyloid-β accumulation and deposition following traumatic brain injury—A narrative review and meta-analysis of animal studies

(2016) Sabine M. Bird et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Repetitive Head Impacts and Chronic Traumatic Encephalopathy

(2016) Ann C. McKee et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Plasma Amyloid-Beta Levels in Patients with Different Types of Cancer

(2016) Wang-Sheng Jin et al.   NEUROTOXICITY RESEARCH

Neurodegeneration, Neurogenesis, and Oxidative Stress 2015

(2016) Renata Santos et al.   Oxidative Medicine and Cellular Longevity

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

(2016) Poomy Pandey et al.   Oncotarget

The Prion-Like Behavior of Assembled Tau in Transgenic Mice

(2016) Florence Clavaguera et al.   Cold Spring Harbor Perspectives in Medicine

CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis

(2016) Anna M Pietroboni et al.   Multiple Sclerosis Journal

CSF tau correlates with CJD disease severity and cognitive decline

(2015) O. S. Cohen et al.   ACTA NEUROLOGICA SCANDINAVICA

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer’s disease and vascular dementia

(2015) Taya Thomas et al.   BRAIN

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

Dementia of the eye: the role of amyloid beta in retinal degeneration

(2015) J A Ratnayaka et al.   EYE

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New Insights in Amyloid Beta Interactions with Human Telomerase

(2015) Jiasi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Type 2 diabetes mellitus and biomarkers of neurodegeneration

(2015) Chris Moran et al.   NEUROLOGY

Low Serum Level α-Synuclein and Tau Protein in Autism Spectrum Disorder Compared to Controls

(2015) Ihsan Cetin et al.   NEUROPEDIATRICS

CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease

(2015) Changqin Liu et al.   PARKINSONISM & RELATED DISORDERS

Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease

(2015) David C. Bäckström et al.   JAMA Neurology

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Risk of Major Cardiovascular Events in People with Down Syndrome

(2015) Christopher G. Sobey et al.   PLoS One

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

(2015) Poomy Pandey et al.   Oncotarget

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

(2014) Mallory Gough et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer

(2014) Seunghwan Lim et al.   BMC CANCER

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

(2014) David Blum et al.   HUMAN MOLECULAR GENETICS

Subretinal injection of amyloid-β peptide accelerates RPE cell senescence and retinal degeneration

(2014) CHAOQI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

(2014) K. Pluci ska et al.   JOURNAL OF NEUROSCIENCE

Estrogen receptor α promotes non-amyloidogenic processing of platelet amyloid precursor protein via the MAPK/ERK pathway

(2014) Chun Shi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice

(2014) Shan Wang et al.   METABOLIC BRAIN DISEASE

Huntington Disease – Principles and practice of nutritional management

(2014) Wioletta Żukiewicz-Sobczak et al.   Neurologia i Neurochirurgia Polska

Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau45-230 transgenic mice

(2014) A.E. Lang et al.   NEUROSCIENCE

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature

(2014) Richard Lathe et al.   BMC Geriatrics

Amyloid precursor protein in human breast cancer: An androgen-induced gene associated with cell proliferation

(2013) Kiyoshi Takagi et al.   CANCER SCIENCE

Distinct Functions of cis and trans Phosphorylated Tau in Alzheimer's Disease and their Therapeutic Implications

(2013) K. Nakamura et al.   CURRENT MOLECULAR MEDICINE

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau protein as a potential predictive marker in epithelial ovarian cancer patients treated with paclitaxel/platinum first-line chemotherapy

(2013) Marta Smoter et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cerebrospinal Fluid Levels of Soluble Amyloid Precursor Protein and β-Amyloid 42 in Patients with Multiple Sclerosis, Neuromyelitis Optica and Clinically Isolated Syndrome

(2013) W Mai et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice

(2013) Matthew R. King et al.   JOURNAL OF NEUROSCIENCE RESEARCH

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

Increases in the Risk of Cognitive Impairment and Alterations of Cerebral β-amyloid Metabolism in Mouse Model of Heart Failure

(2013) Xiaoqi Hong et al.   PLoS One

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart

(2013) Girish C. Melkani et al.   PLoS Genetics

Amyloid-β Peptides and Tau Protein as Biomarkers in Cerebrospinal and Interstitial Fluid Following Traumatic Brain Injury: A Review of Experimental and Clinical Studies

(2013) Parmenion P. Tsitsopoulos et al.   Frontiers in Neurology

Widespread neuronal and glial hyperphosphorylated tau deposition in ALS with cognitive impairment

(2012) Wencheng Yang et al.   Amyotrophic Lateral Sclerosis

Pathologic Accumulation of α-Synuclein and Aβ in Parkinson Disease Patients With Dementia

(2012) Paul T. Kotzbauer et al.   ARCHIVES OF NEUROLOGY

Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration

(2012) Jiying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Pathophysiology and Clinical Presentation of Cerebral Amyloid Angiopathy

(2012) Eitan Auriel et al.   Current Atherosclerosis Reports

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells

(2012) HALEY L. PETERS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Soluble Amyloid Precursor Protein 770 Is Released from Inflamed Endothelial Cells and Activated Platelets

(2012) Shinobu Kitazume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis

(2012) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis

(2012) Kristin Augutis et al.   Multiple Sclerosis Journal

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

Alzheimer’s-Related Peptide Amyloid-β Plays a Conserved Role in Angiogenesis

(2012) D. Joshua Cameron et al.   PLoS One

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study

(2012) Jeffrey Randall et al.   RESUSCITATION

Plasma tau protein in comatose patients after cardiac arrest treated with therapeutic hypothermia

(2011) E. MÖRTBERG et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets

(2011) Tyler A. Kokjohn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

β-Amyloid triggers ALS-associated TDP-43 pathology in AD models

(2011) Alexander M. Herman et al.   BRAIN RESEARCH

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Emerging Histomorphologic Phenotypes of Chronic Traumatic Encephalopathy in American Athletes

(2011) Bennet Omalu et al.   NEUROSURGERY

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker

(2011) Balmiki Ray et al.   PLoS One

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Parallel findings in age-related macular degeneration and Alzheimer’s disease

(2011) Kyoko Ohno-Matsui   PROGRESS IN RETINAL AND EYE RESEARCH

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

A Tangled Web – Tau and Sporadic Parkinson's Disease

(2011) Selina Wray et al.   Frontiers in Psychiatry

Biomarker discovery for Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease

(2010) William T. Hu et al.   ACTA NEUROPATHOLOGICA

Aβ peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis

(2010) Sandra Donnini et al.   FASEB JOURNAL

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging

(2010) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

(2010) Victoria E. Johnson et al.   NATURE REVIEWS NEUROSCIENCE

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

CSF amyloid   1-42 predicts cognitive decline in Parkinson disease

(2010) A. Siderowf et al.   NEUROLOGY

Cognitive and Cortical Plasticity Deficits Correlate with Altered Amyloid-β CSF Levels in Multiple Sclerosis

(2010) Francesco Mori et al.   NEUROPSYCHOPHARMACOLOGY

Viewing Ageing Eyes: Diverse Sites of Amyloid Beta Accumulation in the Ageing Mouse Retina and the Up-Regulation of Macrophages

(2010) Jaimie Hoh Kam et al.   PLoS One

Prion transmission

(2010) Kevin C. Gough et al.   Prion

DRUSEN CHARACTERIZATION WITH MULTIMODAL IMAGING

(2010) Richard F Spaide et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Amyloid-β(1-42) alters structure and function of retinal pigmented epithelial cells

(2009) Julien Bruban et al.   AGING CELL

Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency

(2009) G. Tibolla et al.   ATHEROSCLEROSIS

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Evaluation of Microtubule-Associated Protein-Tau Expression As a Prognostic and Predictive Marker in the NSABP-B 28 Randomized Clinical Trial

(2009) Lajos Pusztai et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

(2009) David J Loane et al.   NATURE MEDICINE

Cortical α-synuclein load is associated with amyloid-β plaque burden in a subset of Parkinson’s disease patients

(2008) Tammaryn Lashley et al.   ACTA NEUROPATHOLOGICA

Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson’s disease

(2008) K. Markopoulou et al.   ACTA NEUROPATHOLOGICA

ADAM-17 predicts adverse outcome in patients with breast cancer

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

Structural Characterization of Binding of Cu(II) to Tau Protein†

(2008) Alice Soragni et al.   BIOCHEMISTRY

Genetic susceptibility in Parkinson's disease

(2008) Jose Miguel Bras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis

(2008) J. M. Anderson et al.   BRAIN

A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long-Term Survivors of Traumatic Brain Injury

(2008) Xiao-Han Chen et al.   BRAIN PATHOLOGY

Retinal tau pathology in human glaucomas

(2008) Neeru Gupta et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association between Deposition of Beta-Amyloid and Pathological Prion Protein in Sporadic Creutzfeldt-Jakob Disease

(2008) Laura Debatin et al.   Neurodegenerative Diseases

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL