Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurological consequences of obesity

(2017) Phillipe D O'Brien et al.   LANCET NEUROLOGY

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer’s Disease Stage in APP/PS1 Mice

(2016) Miren Ettcheto et al.   JOURNAL OF ALZHEIMERS DISEASE

The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice

(2016) Molly Stanley et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

(2015) Auriel A. Willette et al.   Alzheimers & Dementia

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

(2013) Martin Heni et al.   ACTA DIABETOLOGICA

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

(2013) Vera Novak et al.   DIABETES CARE

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells

(2012) Giuseppe Pandini et al.   ENDOCRINOLOGY

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

(2011) Oliver Stöhr et al.   AGE

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Dynamic Analysis of Amyloid  -Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal A  during Age-Related Plaque Formation

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

(2011) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse

(2011) S. Takeda et al.   NEUROSCIENCE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

(2010) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING