Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway

Regional Differences in S-Nitrosylation in the Cortex, Striatum, and Hippocampus of Juvenile Male Mice

(2021) Wajeha Hamoudi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation

(2021) Adva Hadar et al.   MOLECULAR PSYCHIATRY

Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder

(2021) Maryam Kartawy et al.   Brain Sciences

Tau Reduction Prevents Key Features of Autism in Mouse Models

(2020) Chao Tai et al.   NEURON

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

(2020) Diana C. Muñoz-Lasso et al.   Cells

Cell adhesion molecule 2 (CADM2) promotes brain metastasis by inducing epithelial-mesenchymal transition (EMT) in human non-small cell lung cancer

(2020) Lu Dai et al.   Annals of Translational Medicine

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide

(2020) Haitham Amal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tauopathy in the young autistic brain: novel biomarker and therapeutic target

(2020) Iris Grigg et al.   Translational Psychiatry

The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

(2020) Manish Kumar Tripathi et al.   Redox Biology

Sex Differences in Biological Processes and Nitrergic Signaling in Mouse Brain

(2020) Igor Khaliulin et al.   Biomedicines

The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development

(2020) Zhirong Wang et al.   eNeuro

Systems biology reveals reprogramming of the S-nitroso-proteome in the cortical and striatal regions of mice during aging process

(2020) Maryam Kartawy et al.   Scientific Reports

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism

(2019) Eleonora Rosina et al.   Translational Psychiatry

S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy

(2019) Haitham Amal et al.   Translational Psychiatry

Physical Activity Alleviates Cognitive Dysfunction of Alzheimer’s Disease through Regulating the mTOR Signaling Pathway

(2019) Xianjuan Kou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt Signaling Deregulation in the Aging and Alzheimer’s Brain

(2019) Ernest Palomer et al.   Frontiers in Cellular Neuroscience

Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder

(2019) Deborah K. Sokol et al.   Frontiers in Psychiatry

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study

(2019) Yanina Ivashko-Pachima et al.   MOLECULAR PSYCHIATRY

Exploring the Role of P2X Receptors in Alzheimer’s Disease

(2019) Pamela Andrea Godoy et al.   Frontiers in Pharmacology

Abnormal mTOR Activation in Autism

(2018) Kellen D. Winden et al.   Annual Review of Neuroscience

Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation

(2018) Lifu Sheng et al.   CEREBRAL CORTEX

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

(2018) Haitham Amal et al.   MOLECULAR PSYCHIATRY

S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

(2018) Salvatore Rizza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders

(2018) Micaela Lasser et al.   Frontiers in Cellular Neuroscience

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

(2018) Larisa Ryskalin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synapse Stability in the Precuneus Early in the Progression of Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Change in the Posterior Cingulate Gyrus in the Progression of Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

(2018) Gal Hacohen-Kleiman et al.   JOURNAL OF CLINICAL INVESTIGATION

Synaptopathology Involved in Autism Spectrum Disorder

(2018) Shiqi Guang et al.   Frontiers in Cellular Neuroscience

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Protein S-Nitrosylation: Possible Links between Psychophysiological Stress and Neurodegeneration

(2017) Timothy D Foley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition

(2017) Ana Marques-Ramos et al.   RNA

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

(2017) James Gilbert et al.   Frontiers in Cellular Neuroscience

A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity

(2017) Matthew R. Holahan   Frontiers in Cellular Neuroscience

Genome-wide copy number variation analysis in a Chinese autism spectrum disorder cohort

(2017) Hui Guo et al.   Scientific Reports

Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism

(2017) Kit San Yeung et al.   Molecular Autism

mTOR, a Potential Target to Treat Autism Spectrum Disorder

(2016) Atsushi Sato   CNS & Neurological Disorders-Drug Targets

NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?

(2016) Caroline Scholz et al.   European Journal of Medical Genetics

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activity-Regulated Cytoskeleton-Associated Protein Dysfunction May Contribute to Memory Disorder and Earlier Detection of Autism Spectrum Disorders

(2016) Abdulrahman Mohammed Alhowikan   MEDICAL PRINCIPLES AND PRACTICE

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

(2016) Caitlin Mullins et al.   NEURON

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration

(2016) Uthpala Seneviratne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

(2016) Julia Remnestål et al.   Proteomics Clinical Applications

Protein S -Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases

(2016) Tomohiro Nakamura et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

(2016) Junhua Yang et al.   eLife

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Neural Cell Adhesion Molecule 2 Promotes the Formation of Filopodia and Neurite Branching by Inducing Submembrane Increases in Ca2+ Levels

(2015) L. Sheng et al.   JOURNAL OF NEUROSCIENCE

Protein Kinase C-Dependent Growth-Associated Protein 43 Phosphorylation Regulates Gephyrin Aggregation at Developing GABAergic Synapses

(2015) Chen-Yu Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

(2015) Tomohiro Nakamura et al.   NEUROBIOLOGY OF DISEASE

Hippocampal plasticity during the progression of Alzheimer’s disease

(2015) E.J. Mufson et al.   NEUROSCIENCE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies

(2015) A Malishkevich et al.   Translational Psychiatry

Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function

(2015) Anne Biever et al.   Frontiers in Molecular Neuroscience

Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects

(2015) Regina F. Nasyrova et al.   Frontiers in Physiology

Roles of mTOR Signaling in Brain Development

(2015) Da Yong Lee   Experimental Neurobiology

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2

(2014) E. Lopez-Rivera et al.   CANCER RESEARCH

Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine

(2014) Brian Dean et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Gap43 Transcription Modulation in the Adult Brain Depends on Sensory Activity and Synaptic Cooperation

(2014) Nicole Rosskothen-Kuhl et al.   PLoS One

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease

(2013) Florian Haun et al.   ANTIOXIDANTS & REDOX SIGNALING

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model

(2013) Robert K. Naviaux et al.   PLoS One

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway

(2013) Debomoy K. Lahiri et al.   Frontiers in Cellular Neuroscience

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

(2013) Michael Wong   Biomedical Journal

Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

(2012) D. A. Altomare et al.   CURRENT MEDICINAL CHEMISTRY

Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease

(2012) Ming-Hui Yang et al.   Journal of Proteomics

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons

(2011) Kazumasa Yokoyama et al.   EMBO JOURNAL

Synaptic Stimulation of mTOR Is Mediated by Wnt Signaling and Regulation of Glycogen Synthetase Kinase-3

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker

(2011) Balmiki Ray et al.   PLoS One

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Synapse Pathology in Psychiatric and Neurologic Disease

(2010) Myrrhe van Spronsen et al.   Current Neurology and Neuroscience Reports

Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice

(2010) K. J. Zaccaria et al.   GENES BRAIN AND BEHAVIOR

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

(2009) S. W. Way et al.   HUMAN MOLECULAR GENETICS

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY