Neuronal human BACE1 knockin induces systemic diabetes in mice

Reduced Limbic and Hypothalamic Volumes Correlate with Bone Density in Early Alzheimer's Disease

(2017) Natalia Loskutova et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics

(2015) Annapaola Prestia et al.   Alzheimers & Dementia

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

(2015) Marja-Riitta Taskinen et al.   ATHEROSCLEROSIS

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

The brown fat secretome: metabolic functions beyond thermogenesis

(2015) Guo-Xiao Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease

(2015) P Proitsi et al.   Translational Psychiatry

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

(2014) K. Pluci ska et al.   JOURNAL OF NEUROSCIENCE

Diabetes and Elevated Hemoglobin A1c Levels Are Associated with Brain Hypometabolism but Not Amyloid Accumulation

(2014) R. O. Roberts et al.   JOURNAL OF NUCLEAR MEDICINE

Metabolomic study of lipids in serum for biomarker discovery in Alzheimer's disease using direct infusion mass spectrometry

(2014) R. González-Domínguez et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Lipid Integration in Neurodegeneration: An Overview of Alzheimer’s Disease

(2014) Rajesh Singh Yadav et al.   MOLECULAR NEUROBIOLOGY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression

(2013) Albrecht Hoffmeister et al.   Obesity

The Role of Gastrointestinal Hormones in Hepatic Lipid Metabolism

(2013) Jamie Mells et al.   SEMINARS IN LIVER DISEASE

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

(2012) G. D. Mcilroy et al.   DIABETES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1

(2012) K. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism

(2012) J. Norseen et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

The role of leptin in glucose homeostasis

(2012) Heather C Denroche et al.   Journal of Diabetes Investigation

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Hypocretin (orexin) loss in Alzheimer's disease

(2011) Rolf Fronczek et al.   NEUROBIOLOGY OF AGING

Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1

(2011) Bettina Platt et al.   PLoS One

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coomassie Staining as Loading Control in Western Blot Analysis

(2010) Charlotte Welinder et al.   JOURNAL OF PROTEOME RESEARCH

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

(2009) W. L. Xu et al.   DIABETOLOGIA

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

(2009) Matthew L. Hemming et al.   PLoS One