Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

(2020) Eyiyemisi C. Damisah et al.   Science Advances

Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy

(2019) Zhongbo Chen et al.   MOVEMENT DISORDERS

Extracellular Monomeric Tau Is Internalized by Astrocytes

(2019) Juan Ramón Perea et al.   Frontiers in Neuroscience

CA1-projecting subiculum neurons facilitate object–place learning

(2019) Yanjun Sun et al.   NATURE NEUROSCIENCE

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

(2019) Kevin Carvalho et al.   BRAIN

Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations

(2019) Amber Nolan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

(2019) Sneha Narasimhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes

(2018) Isidro Ferrer et al.   BRAIN PATHOLOGY

Phagocytic response of astrocytes to damaged neighboring cells

(2018) Nicole M. Wakida et al.   PLoS One

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Astrocytic degeneration in chronic traumatic encephalopathy

(2018) Eric T. Hsu et al.   ACTA NEUROPATHOLOGICA

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

(2017) Angela Gomez-Arboledas et al.   GLIA

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

(2017) Gabor G. Kovacs et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

(2017) Marta Sidoryk-Wegrzynowicz et al.   Acta Neuropathologica Communications

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes

(2016) Tal Iram et al.   JOURNAL OF NEUROSCIENCE

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression

(2016) K Le Guennec et al.   MOLECULAR PSYCHIATRY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Repair of Rhodopsin mRNA by Spliceosome-Mediated RNA Trans -Splicing: A New Approach for Autosomal Dominant Retinitis Pigmentosa

(2015) Adeline Berger et al.   MOLECULAR THERAPY

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology

(2013) Katja Hochgräfe et al.   FEBS Journal

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort

(2012) G. Lace et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Spatial patterns of the tau pathology in progressive supranuclear palsy

(2012) Richard A. Armstrong et al.   NEUROLOGICAL SCIENCES

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model

(2011) Astrid Sydow et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging

(2011) S. Jinno   NEUROSCIENCE

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

(2009) Hsiao-Huei Wu et al.   NATURE NEUROSCIENCE

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE