Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

(2020) Ana I. Duarte et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer’s mouse model

(2020) Sitara B. Sankar et al.   Journal of Neuroinflammation

Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

(2020) Ana F. Raimundo et al.   Frontiers in Molecular Neuroscience

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

(2019) Raluca Ştefănescu et al.   MOLECULES

Understanding the Amyloid Hypothesis in Alzheimer’s Disease

(2019) Giulia Paroni et al.   JOURNAL OF ALZHEIMERS DISEASE

Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β

(2019) Mei Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diabetes drugs in the fight against Alzheimer's disease

(2019) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Trends in incidence of total or type 2 diabetes: systematic review

(2019) Dianna J Magliano et al.   BMJ-British Medical Journal

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

(2019) Martin Tolar et al.   Alzheimers & Dementia

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

(2019) Heinz Hillen   Frontiers in Neuroscience

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

(2019) Gabriela Dumitrita Stanciu et al.   Biomolecules

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

(2018) Anna Spanopoulou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential

(2018) N.M. Pathak et al.   BIOCHEMICAL PHARMACOLOGY

IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

(2018) Shreyasi Asthana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease

(2018) Mohammad Hossein Esmaeili et al.   BRAIN RESEARCH BULLETIN

Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030

(2018) Christian Bommer et al.   DIABETES CARE

Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis

(2018) Bing Cao et al.   DIABETES OBESITY & METABOLISM

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Review: Relationship of type 2 diabetes to human brain pathology

(2018) J. J. Pruzin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Vildagliptin, a DPP4 inhibitor, alleviates diabetes‑associated cognitive deficits by decreasing the levels of apoptosis‑related proteins in the rat hippocampus

(2018) Dan‑Dan Zhang et al.   Experimental and Therapeutic Medicine

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease

(2018) Ahmed Morsy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sitagliptin protects the cognition function of the Alzheimer’s disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings

(2018) Qing Dong et al.   NEUROSCIENCE LETTERS

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease

(2017) Qing‑Hua Ma et al.   Molecular Medicine Reports

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

(2017) Carmen Infante-Garcia et al.   MOLECULAR NEUROBIOLOGY

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease

(2017) Pedro Cisternas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Diabetes 2030: Insights from Yesterday, Today, and Future Trends

(2017) William R. Rowley et al.   Population Health Management

Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?

(2017) Yun Zhang et al.   PROGRESS IN NEUROBIOLOGY

Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease

(2017) Rohit Pardeshi et al.   PSYCHONEUROENDOCRINOLOGY

Clinical reasoning in feline epilepsy: Which combination of clinical information is useful?

(2017) Gabriela-Dumitrita Stanciu et al.   VETERINARY JOURNAL

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

(2017) Deepti Goyal et al.   ACS Combinatorial Science

Evaluation of central vestibular syndrome in dogs using brainstem auditory evoked responses recorded with surface electrodes

(2016) G.D Stanciu et al.   ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

(2016) Clara Iannuzzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acute idiopathic polyradiculoneuritis concurrent with acquired myasthenia gravis in a West Highland white terrier dog

(2016) Gabriela Dumitrita Stanciu et al.   BMC Veterinary Research

Challenges in studying the structures of metal-amyloid oligomers related to type 2 diabetes, Parkinson's disease, and Alzheimer's disease

(2016) Vered Wineman-Fisher et al.   COORDINATION CHEMISTRY REVIEWS

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Effects of Hypertension and Anti-Hypertensive Treatment on Amyloid-β (Aβ) Plaque Load and Aβ-Synthesizing and Aβ-Degrading Enzymes in Frontal Cortex

(2016) Emma L. Ashby et al.   JOURNAL OF ALZHEIMERS DISEASE

Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2016) Jayasankar Kosaraju et al.   MOLECULAR NEUROBIOLOGY

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Mouse Models of Diabetes, Obesity and Related Kidney Disease

(2016) Sarah J. Glastras et al.   PLoS One

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Current aspects of the interactions between dementia, the brain renin-angiotensin system and oxidative stress

(2015) Dragomir Serban et al.   Archives of Biological Sciences

Brainstem auditory evoked responses in healthy Argentine Mastiff dogs recorded with surface electrodes

(2015) M. Armașu et al.   ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice

(2015) De-Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Diabetes Mellitus Accelerates Aβ Pathology in Brain Accompanied by Enhanced GAβ Generation in Nonhuman Primates

(2015) Sachi Okabayashi et al.   PLoS One

The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

(2014) Christian Hölscher   Alzheimers & Dementia

Amyloid-based nanosensors and nanodevices

(2014) Charlotte A. E. Hauser et al.   CHEMICAL SOCIETY REVIEWS

Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease

(2014) G. Aliev et al.   CURRENT MEDICINAL CHEMISTRY

Intracerebroventricular administration of streptozotocin as an experimental approach to Alzheimer's disease

(2014) Konstantinos Kalafatakis et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

(2014) Sarah Srodulski et al.   Molecular Neurodegeneration

Association of type 2 diabetes with brain atrophy and cognitive impairment

(2014) R. O. Roberts et al.   NEUROLOGY

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

(2014) Paula L. McClean et al.   NEUROPHARMACOLOGY

Changes in Diabetes-Related Complications in the United States, 1990–2010

(2014) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Selectively N-Methylated Soluble IAPP Mimics as Potent IAPP Receptor Agonists and Nanomolar Inhibitors of Cytotoxic Self-Assembly of Both IAPP and Aβ40

(2013) Li-Mei Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

(2013) Brittany L. Adler et al.   NEUROBIOLOGY OF AGING

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

High Glucose Promotes Aβ Production by Inhibiting APP Degradation

(2013) Yi Yang et al.   PLoS One

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance

(2012) Margarita Jiménez-Palomares et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats

(2012) Akiko Sheala Shingo et al.   BEHAVIOURAL BRAIN RESEARCH

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

(2012) Naoki Yamamoto et al.   JOURNAL OF NEUROCHEMISTRY

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

(2012) Wei-Na Han et al.   NEUROBIOLOGY OF AGING

Risk of Alzheimer’s Disease in Relation to Diabetes: A Population-Based Cohort Study

(2012) Kai-Chen Wang et al.   NEUROEPIDEMIOLOGY

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes

(2011) Ejaz Ahmad et al.   BIOCHIMIE

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling

(2011) J Bailey et al.   PHYSICAL BIOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

(2010) David S. Geldmacher et al.   ARCHIVES OF NEUROLOGY

Insulin resistance, diabetes and cognitive function: Consequences for preventative strategies

(2010) I. Bourdel-Marchasson et al.   DIABETES & METABOLISM

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.

(2009) V. Haj-ali et al.   BEHAVIORAL NEUROSCIENCE

Relationship Between Baseline Glycemic Control and Cognitive Function in Individuals With Type 2 Diabetes and Other Cardiovascular Risk Factors: The Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial

(2009) T. Cukierman-Yaffe et al.   DIABETES CARE

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

(2009) W. L. Xu et al.   DIABETOLOGIA

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY