Increased β‐site APP cleaving enzyme 1‐mediated insulin receptor cleavage in type 2 diabetes mellitus with cognitive impairment

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

(2020) Qiao Shi et al.   DIABETES CARE

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

(2019) Andrea Vergallo et al.   Alzheimers & Dementia

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

(2018) Yong Shen et al.   BIOLOGICAL PSYCHIATRY

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment

(2018) Igor Pomytkin et al.   CNS Neuroscience & Therapeutics

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

(2018) Paul J. Meakin et al.   Nature Communications

Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier

(2018) Peter Van Dyken et al.   Frontiers in Neuroscience

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

(2017) Masahiro Konishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

(2017) Ryusuke Takechi et al.   Frontiers in Aging Neuroscience

Post-translational regulation of the β-secretase BACE1

(2016) Wataru Araki   BRAIN RESEARCH BULLETIN

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

(2015) Matthew Baumgart et al.   Alzheimers & Dementia

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

(2015) Y. Kizuka et al.   EMBO Molecular Medicine

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

(2015) Kavi Devraj et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy

(2014) X. Cheng et al.   NEUROLOGY

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

(2013) Vera Novak et al.   DIABETES CARE

HbA1c and Risk of Severe Hypoglycemia in Type 2 Diabetes: The Diabetes and Aging Study

(2013) K. J. Lipska et al.   DIABETES CARE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study

(2013) Richard H Tuligenga et al.   Lancet Diabetes & Endocrinology

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Cognitive function, dementia and type 2 diabetes mellitus in the elderly

(2011) Mark W. J. Strachan et al.   Nature Reviews Endocrinology

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE