Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer’s Disease

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

(2017) Michael C. Donohue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Method for Direct Assessment of Everyday Competence Among Older Adults

(2017) Sara J. Czaja et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid and tau PET demonstrate region-specific associations in normal older people

(2017) Samuel N. Lockhart et al.   NEUROIMAGE

Cued memory decline in biomarker-defined preclinical Alzheimer disease

(2017) Kathryn V. Papp et al.   NEUROLOGY

Regional correlations between [ 11 C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort

(2017) Sang Won Seo et al.   NeuroImage-Clinical

Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study

(2016) Lindsay R. Clark et al.   Alzheimers & Dementia

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging

(2016) Brian A. Gordon et al.   BRAIN

Psychometric Properties of the Memory Binding Test: Test-Retest Reliability and Convergent Validity

(2016) Nina Gramunt et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study

(2016) Samantha C Burnham et al.   LANCET NEUROLOGY

Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly

(2016) Jasmeer P. Chhatwal et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Biomarker validation of a decline in semantic processing in preclinical Alzheimer’s disease.

(2016) Kathryn V. Papp et al.   NEUROPSYCHOLOGY

Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease

(2016) Xiuming Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity in Suspected Non–Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals

(2016) Elizabeth C. Mormino et al.   JAMA Neurology

Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change

(2016) Anja Soldan et al.   JAMA Neurology

Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community

(2016) Ronald C. Petersen et al.   JAMA Neurology

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

(2015) Osama Sabri et al.   Alzheimers & Dementia

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease

(2015) Rik Ossenkoppele et al.   HUMAN BRAIN MAPPING

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Learning classification models of cognitive conditions from subtle behaviors in the digital Clock Drawing Test

(2015) William Souillard-Mandar et al.   MACHINE LEARNING

Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease

(2015) Kathryn V. Papp et al.   NEUROPSYCHOLOGIA

An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease

(2014) Jessica B. Langbaum et al.   Alzheimers & Dementia

Predicting Alzheimer disease with β-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing

(2014) Christopher C. Rowe et al.   ANNALS OF NEUROLOGY

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease

(2014) Y Y Lim et al.   MOLECULAR PSYCHIATRY

Amyloid and APOE  4 interact to influence short-term decline in preclinical Alzheimer disease

(2014) E. C. Mormino et al.   NEUROLOGY

The Preclinical Alzheimer Cognitive Composite

(2014) Michael C. Donohue et al.   JAMA Neurology

Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

(2014) Elizabeth C. Mormino et al.   JAMA Neurology

Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

(2014) Jon B Toledo et al.   Acta Neuropathologica Communications

Unobtrusive measurement of daily computer use to detect mild cognitive impairment

(2013) Jeffrey Kaye et al.   Alzheimers & Dementia

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease

(2013) Yen Ying Lim et al.   BRAIN

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease

(2013) Yen Ying Lim et al.   NEUROBIOLOGY OF AGING

Amyloid burden and neural function in people at risk for Alzheimer's Disease

(2013) Sterling C. Johnson et al.   NEUROBIOLOGY OF AGING

Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later

(2013) C. M. Roe et al.   NEUROLOGY

Preclinical AD predicts decline in memory and executive functions in subjective complaints

(2013) A. C. van Harten et al.   NEUROLOGY

A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment

(2013) Shauna M. Stark et al.   NEUROPSYCHOLOGIA

Cross-sectional and Longitudinal Analysis of the Relationship Between Aβ Deposition, Cortical Thickness, and Memory in Cognitively Unimpaired Individuals and in Alzheimer Disease

(2013) Vincent Doré et al.   JAMA Neurology

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

(2012) Susan M. Landau et al.   ANNALS OF NEUROLOGY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic and Lifestyle Predictors of 15-Year Longitudinal Change in Episodic Memory

(2012) Maria Josefsson et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study

(2012) Jennifer L Whitwell et al.   LANCET NEUROLOGY

Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan

(2012) Kristen M. Kennedy et al.   NEUROIMAGE

Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

(2012) D. S. Knopman et al.   NEUROLOGY

Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease

(2012) M. Wagner et al.   NEUROLOGY

Amyloid-  assessed by florbetapir F 18 PET and 18-month cognitive decline: A multicenter study

(2012) P. M. Doraiswamy et al.   NEUROLOGY

Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology

(2012) Robert W. Mahley et al.   NEURON

Memory aging and brain maintenance

(2012) Lars Nyberg et al.   TRENDS IN COGNITIVE SCIENCES

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Assessment of cognition in mild cognitive impairment: A comparative study

(2011) Peter J. Snyder et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

(2011) Clifford R. Jack et al.   ANNALS OF NEUROLOGY

A  Deposition in Aging Is Associated with Increases in Brain Activation during Successful Memory Encoding

(2011) E. C. Mormino et al.   CEREBRAL CORTEX

Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging

(2011) Elizabeth C. Mormino et al.   CEREBRAL CORTEX

Specific Subjective Memory Complaints in Older Persons May Indicate Poor Cognitive Function

(2011) Rebecca England Amariglio et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Education Does Not Slow Cognitive Decline with Aging: 12-Year Evidence from the Victoria Longitudinal Study

(2011) Laura B. Zahodne et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Face-name associative memory performance is related to amyloid burden in normal elderly

(2011) Dorene M. Rentz et al.   NEUROPSYCHOLOGIA

Lifespan brain activity, β-amyloid, and Alzheimer's disease

(2011) William J. Jagust et al.   TRENDS IN COGNITIVE SCIENCES

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Amyloid-β associated cortical thinning in clinically normal elderly

(2010) J. Alex Becker et al.   ANNALS OF NEUROLOGY

Visual short-term memory binding deficits in familial Alzheimer’s disease

(2010) Mario A. Parra et al.   BRAIN

Object Unitization and Associative Memory Formation Are Supported by Distinct Brain Regions

(2010) B. P. Staresina et al.   JOURNAL OF NEUROSCIENCE

In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18)

(2010) D. F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

(2010) S. M. Resnick et al.   NEUROLOGY

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Cognitive Decline and Brain Volume Loss as Signatures of Cerebral Amyloid-β Peptide Deposition Identified With Pittsburgh Compound B

(2009) Martha Storandt et al.   ARCHIVES OF NEUROLOGY

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

(2009) T. Hedden et al.   JOURNAL OF NEUROSCIENCE

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Decomposing age correlations on neuropsychological and cognitive variables

(2009) TIMOTHY A. SALTHOUSE   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptive Brain: Aging and Neurocognitive Scaffolding

(2008) Denise C. Park et al.   Annual Review of Psychology

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY