A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

Grape Seed Polyphenolic Extract Specifically Decreases Aβ*56 in the Brains of Tg2576 Mice

(2018) Peng Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Caspase-2 and tau—a toxic partnership?

(2016) Carol M Troy et al.   NATURE MEDICINE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

(2016) Maria Jimenez-Sanchez et al.   Cold Spring Harbor Perspectives in Medicine

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

(2014) David Blum et al.   HUMAN MOLECULAR GENETICS

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease

(2014) Maud Gratuze et al.   HUMAN MOLECULAR GENETICS

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

(2011) Michel C. Maillard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

(2011) Jeffrey B Carroll et al.   Molecular Neurodegeneration

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Association of corticobasal degeneration and Huntington's disease: Can Tau aggregates protect Huntingtin toxicity?

(2009) Dominique Caparros-Lefebvre et al.   MOVEMENT DISORDERS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE