The beta secretase BACE1 regulates the expression of insulin receptor in the liver

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

(2018) Paul J. Meakin et al.   Scientific Reports

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma

(2017) Lucille Morzyglod et al.   HEPATOLOGY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity

(2016) Vanessa Schmidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

(2016) Matteo Oliverio et al.   NATURE CELL BIOLOGY

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

(2016) Arvindhan Nagarajan et al.   Nature Communications

Development of in vitro model of insulin receptor cleavage induced by high glucose in HepG2 cells

(2014) Tomoyuki Yuasa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes

(2014) K. Pluci ska et al.   JOURNAL OF NEUROSCIENCE

Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes

(2014) Marcia Hiriart et al.   Frontiers in Endocrinology

Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors

(2013) Hamza Chettouh et al.   CANCER RESEARCH

BACE1 as a Therapeutic Target in Alzheimer’s Disease: Rationale and Current Status

(2013) Genevieve Evin et al.   DRUGS & AGING

The Serine Protease Granzyme B as an Inflammatory Marker, in Relation to the Insulin Receptor Cleavage in Human Obesity and Type 2 Diabetes Mellitus

(2013) Hala O. El Mesallamy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor

(2013) J Liu et al.   ONCOGENE

The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase

(2013) S. R. Hubbard   Cold Spring Harbor Perspectives in Biology

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

(2012) Marjorie Poggi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

(2012) Joel T. Haas et al.   Cell Metabolism

Leprechaunism (Donohue syndrome): A case bearing novel compound heterozygous mutations in the insulin receptor gene

(2012) Yuki Kawashima et al.   ENDOCRINE JOURNAL

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage

(2011) M. Maesako et al.   NEUROSCIENCE

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Ectodomain shedding of TNF-α is enhanced by nardilysin via activation of ADAM proteases

(2008) Yoshinori Hiraoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts

(2008) Maiko Ebina et al.   JOURNAL OF NEUROSCIENCE RESEARCH