mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62

(2013) Hyun-Jung Jung et al.   EXPERIMENTAL NEUROLOGY

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice

(2013) Jency Thomas et al.   METABOLIC BRAIN DISEASE

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection

(2012) Hei-Jen Huang et al.   PLoS One

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

In vitro modelling of Alzheimer's disease: Degeneration and cell death induced by viral delivery of amyloid and tau

(2011) Sandra Stoppelkamp et al.   EXPERIMENTAL NEUROLOGY

Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse

(2011) Shan Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy

(2011) Jorge L. Jacot et al.   Journal of Ophthalmology

Ghrelin Modulates Insulin Sensitivity and Tau Phosphorylation in High Glucose-Induced Hippocampal Neurons

(2010) Ying Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of rapamycin

(2010) G. Liu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

(2010) Ann Van der Jeugd et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Short-Term Environmental Enrichment Enhances Adult Neurogenesis, Vascular Network and Dendritic Complexity in the Hippocampus of Type 1 Diabetic Mice

(2010) Juan Beauquis et al.   PLoS One

Neuronal Plasticity and Antidepressants in the Diabetic Brain

(2009) Juan Beauquis et al.   Annals of the New York Academy of Sciences

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice

(2009) Tomasz Jaworski et al.   PLoS One

Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes

(2008) Edgardo O. Alvarez et al.   BEHAVIOURAL BRAIN RESEARCH

Role of TSC–mTOR pathway in diabetic nephropathy

(2008) Ken Inoki   DIABETES RESEARCH AND CLINICAL PRACTICE

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE

Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats

(2007) W.-J. Zhang et al.   ACTA NEUROLOGICA SCANDINAVICA

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS