Cancer-Associated Fibroblasts: Heterogeneity and Bimodality in Oncogenesis

TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer

(2022) Binbin Liu et al.   International Journal of Biological Sciences

Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer

(2022) Ryosuke Ichihara et al.   PATHOLOGY INTERNATIONAL

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

(2022) Shaoquan Zheng et al.   OncoImmunology

Cancer-Associated Fibroblasts Regulate Kinase Activity in Mesothelioma Cell Lines via Paracrine Signaling and Thereby Dictate Cell Faith and Behavior

(2022) Alexander Mathilakathu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets

(2022) Shinelle Menezes et al.   JOURNAL OF PATHOLOGY

Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts

(2022) Yoshihiro Miyazaki et al.   Cancers

MicroRNA-138 Abates Fibroblast Motility With Effect on Invasion of Adjacent Cancer Cells

(2022) Saroj Rajthala et al.   Frontiers in Oncology

miR‑491‑3p functions as a tumor suppressor in non‑small cell lung cancer by targeting fibroblast growth factor 5

(2022) Gai Zhang et al.   ONCOLOGY REPORTS

Identification of a Gene Signature of Cancer-Associated Fibroblasts to Predict Prognosis in Ovarian Cancer

(2022) Li Zeng et al.   Frontiers in Genetics

Construction and Verification of a Fibroblast-Related Prognostic Signature Model for Colon Cancer

(2022) Zhe Zhao et al.   Frontiers in Genetics

Identification and Characterization of Cancer-Associated Fibroblast Subpopulations in Lung Adenocarcinoma

(2022) Daeseung Kim et al.   Cancers

DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1

(2022) Favour A. Akinjiyan et al.   Cancers

Correlation of tumor microenvironment-related markers with clinical outcomes in patients with squamous cell carcinoma of the lung

(2022) Mayu Sugai et al.   Translational Lung Cancer Research

Gene Expression Profile of Stromal Factors in Cancer-Associated Fibroblasts from Prostate Cancer

(2022) Noemi Eiro et al.   Diagnostics

Cancer‐associated fibroblast‐derived exosomal microRNA‐20a suppresses the PTEN/PI3K‐AKT pathway to promote the progression and chemoresistance of non‐small cell lung cancer

(2022) Lin Shi et al.   Clinical and Translational Medicine

Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer

(2021) Nina G Steele et al.   CLINICAL CANCER RESEARCH

Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

(2021) Sujun Chen et al.   NATURE CELL BIOLOGY

Fibroblast Subsets in Intestinal Homeostasis, Carcinogenesis, Tumor Progression, and Metastasis

(2021) Hao Dang et al.   Cancers

Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity

(2021) Tuxiong Huang et al.   GUT

Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway

(2021) Weiqiang Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling

(2021) Yingyan Wang et al.   Cell Death & Disease

Collagen Type XI Alpha 1 (COL11A1): A Novel Biomarker and a Key Player in Cancer

(2021) Sameera Nallanthighal et al.   Cancers

Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts

(2021) Jessica Karta et al.   Cells

Cancer-Associated Fibroblasts Suppress Cancer Development: The Other Side of the Coin

(2021) Zhanhuai Wang et al.   Frontiers in Cell and Developmental Biology

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

(2021) Silvia Affo et al.   CANCER CELL

Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation

(2021) Pablo Moreno-Ruiz et al.   LUNG CANCER

Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment

(2021) Lenka N.C. Boyd et al.   SEMINARS IN CANCER BIOLOGY

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation

(2021) Lusheng Wei et al.   Cell Death & Disease

In-Depth Characterization of Stromal Cells within the Tumor Microenvironment Yields Novel Therapeutic Targets

(2021) Sebastian G. Walter et al.   Cancers

The Role of Cancer-Associated Fibroblasts in Tumor Progression

(2021) Rushikesh S. Joshi et al.   Cancers

Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer

(2021) Mengxuan Yang et al.   Frontiers in Oncology

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

(2021) Colin Hutton et al.   CANCER CELL

Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T cell suppression

(2021) Go Itoh et al.   Molecular Oncology

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response

(2021) Yu Wang et al.   Cell Discovery

Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression

(2021) Kenta Haga et al.   Translational Oncology

Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer

(2021) Xuechun Li et al.   Theranostics

Diminished CD68+ Cancer-Associated Fibroblast Subset Induces Treg Infiltration and Predicts Poor Prognosis of Oral Squamous Cell Carcinoma Patients

(2020) Xingxing Zhao et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer‐associated fibroblasts that restrain cancer progression (rCAFs): hypotheses and perspectives

(2020) Yuki Miyai et al.   CANCER SCIENCE

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

(2020) Chi Shu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Cancer-associated fibroblasts promote cell growth by activating ERK5/PD-L1 signaling axis in colorectal cancer

(2020) Mengyan Zhang et al.   PATHOLOGY RESEARCH AND PRACTICE

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

(2020) Handong Ma et al.   Cell Reports

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

The double-edged sword role of fibroblasts in the interaction with cancer cells; an agent-based modeling approach

(2020) Zarifeh Heidary et al.   PLoS One

Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer

(2020) Yann Kieffer et al.   Cancer Discovery

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

(2020) Sarah Davidson et al.   Cell Reports

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

(2020) Aimy Sebastian et al.   Cancers

Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

(2020) Sunny Z Wu et al.   EMBO JOURNAL

An Analysis Regarding the Association Between the ISLR Gene and Gastric Carcinogenesis

(2020) Shu Li et al.   Frontiers in Genetics

The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

(2020) Francesco Bonollo et al.   Cancers

Tumor-Educated Neutrophils Activate Mesenchymal Stem Cells to Promote Gastric Cancer Growth and Metastasis

(2020) Jiahui Zhang et al.   Frontiers in Cell and Developmental Biology

Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling

(2020) Junli Zhang et al.   Annals of Translational Medicine

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

(2020) Zhaohui Chen et al.   Nature Communications

Cancer-Associated Fibroblasts: Understanding Their Heterogeneity

(2020) Kévin Louault et al.   Cancers

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

(2020) Angelo L. Grauel et al.   Nature Communications

Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

(2020) Richard Lee Barrett et al.   eLife

A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue

(2020) Barbara Bellei et al.   Cancers

Extracellular Vesicles Are Key Regulators of Tumor Neovasculature

(2020) Naoya Kuriyama et al.   Frontiers in Cell and Developmental Biology

Downregulation of miRNA-214 in cancer-associated fibroblasts contributes to migration and invasion of gastric cancer cells through targeting FGF9 and inducing EMT

(2019) Ruifen Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers

(2019) K. Louault et al.   ONCOGENE

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

(2019) Nicola Ferrari et al.   Nature Communications

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Impact of Epithelial–Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ

(2019) Carina Strell et al.   JNCI-Journal of the National Cancer Institute

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

In search of definitions: Cancer-associated fibroblasts and their markers

(2019) Martin Nurmik et al.   INTERNATIONAL JOURNAL OF CANCER

Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets

(2019) Martin C. Whittle et al.   GASTROENTEROLOGY

Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy

(2019) Dhruba Kadel et al.   CELL BIOLOGY AND TOXICOLOGY

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies

(2019) Go J. Yoshida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

(2019) Shihua Wang et al.   Stem Cell Research & Therapy

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway

(2019) Dunxin Han et al.   Cancer Management and Research

Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

(2019) Tianyi Liu et al.   Frontiers in Cell and Developmental Biology

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

(2019) Yasuyuki Mizutani et al.   CANCER RESEARCH

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant

(2019) Pino Bordignon et al.   Cell Reports

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

(2019) Lea Monteran et al.   Frontiers in Immunology

Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-β signalling

(2019) Chao Huang et al.   Journal of Cell Communication and Signaling

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer

(2019) Daniela Unterleuthner et al.   ANGIOGENESIS

Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts

(2019) Kun Dai et al.   ONCOGENE

Heterogeneity of human prostate carcinoma‐associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment

(2019) Renee E. Vickman et al.   PROSTATE

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A

(2019) Hua Guo et al.   Cancer Cell International

Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis

(2018) Yinlong Zhang et al.   ACS Applied Materials & Interfaces

Colorectal cancer cell–derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway

(2018) Guangyao Dai et al.   BULLETIN DU CANCER

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts

(2018) Diana Avery et al.   MATRIX BIOLOGY

Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer

(2018) Ayse Ceren Mutgan et al.   Molecular Cancer

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Micro-RNA-21 Regulates Cancer-Associated Fibroblast-Mediated Drug Resistance in Pancreatic Cancer

(2018) Lulin Zhang et al.   ONCOLOGY RESEARCH

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

(2018) Magdolna Djurec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

(2018) Anne-Marie Givel et al.   Nature Communications

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

(2018) Emelie Berglund et al.   Nature Communications

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

(2018) Matthew A. Lakins et al.   Nature Communications

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

(2018) Linda Ziani et al.   Frontiers in Immunology

The Expression of FAP in Hepatocellular Carcinoma Cells is Induced by Hypoxia and Correlates with Poor Clinical Outcomes

(2018) Baojia Zou et al.   Journal of Cancer

Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1

(2018) Alberto Herrera et al.   Oncogenesis

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

Internalization of Exosomes through Receptor-mediated Endocytosis

(2018) Amber Gonda et al.   MOLECULAR CANCER RESEARCH

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

(2018) Valentina Poltavets et al.   Frontiers in Oncology

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

(2018) Siyang Wen et al.   CANCER LETTERS

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

(2017) Komal Qureshi-Baig et al.   Molecular Cancer

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer

(2017) Daniel Monti et al.   SEMINARS IN ONCOLOGY

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

(2017) Neha Nair et al.   Scientific Reports

Cancer-associated fibroblasts support vascular growth through mechanical force

(2017) Mary Kathryn Sewell-Loftin et al.   Scientific Reports

Vitamin D and Myofibroblasts in Fibrosis and Cancer: At Cross-purposes with TGF-β/SMAD Signaling

(2016) SHRAGA SHANY et al.   ANTICANCER RESEARCH

A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

(2016) Dongyu Jia et al.   CANCER LETTERS

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas

(2016) Yoshihiro Mezawa et al.   CELL AND TISSUE RESEARCH

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment

(2016) Xin Zheng et al.   CELLULAR SIGNALLING

Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen

(2016) Heather M. Brechbuhl et al.   CLINICAL CANCER RESEARCH

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Pericyte–fibroblast transition promotes tumor growth and metastasis

(2016) Kayoko Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells

(2016) Keiko Maeda et al.   Scientific Reports

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

(2016) Kristin Stock et al.   Scientific Reports

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2015) Berna C. Özdemir et al.   CANCER CELL

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

(2015) Jean Albrengues et al.   Nature Communications

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Platelet-Derived Growth Factor Receptor Alpha as a Marker of Mesenchymal Stem Cells in Development and Stem Cell Biology

(2015) Ramin M. Farahani et al.   Stem Cells International

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man

(2015) Verena K. Raker et al.   Frontiers in Immunology

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Recruitment of CD34 + Fibroblasts in Tumor-Associated Reactive Stroma

(2014) Rebeca San Martin et al.   AMERICAN JOURNAL OF PATHOLOGY

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

(2014) Y Hassona et al.   BRITISH JOURNAL OF CANCER

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Expression of smooth muscle cell markers and co-activators in calcified aortic valves

(2014) Najma Latif et al.   EUROPEAN HEART JOURNAL

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

(2014) Ana Costa et al.   SEMINARS IN CANCER BIOLOGY

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

(2014) James Harper et al.   SEMINARS IN CANCER BIOLOGY

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

(2014) Jean Albrengues et al.   Cell Reports

Fibroblast-Specific Protein 1/S100A4-Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens

(2013) J. Zhang et al.   CANCER RESEARCH

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

Cancer metabolism, stemness and tumor recurrence

(2013) Joseph M. Curry et al.   CELL CYCLE

Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8

(2013) A Q Sukkurwala et al.   CELL DEATH AND DIFFERENTIATION

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

(2013) Lisa D. Mills et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

(2013) Fiorenza Lotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Roles of PDGF in Development and During Neurogenesis in the Normal and Diseased Nervous System

(2013) Keiko Funa et al.   Journal of Neuroimmune Pharmacology

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer

(2013) S Busch et al.   ONCOGENE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer

(2012) Alexandra Giatromanolaki et al.   CANCER BIOLOGY & THERAPY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy

(2012) W. N. Brennen et al.   MOLECULAR CANCER THERAPEUTICS

Tumor stroma as targets for cancer therapy

(2012) Jing Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the  c cytokines and TGF- 1

(2011) Y. P. Park et al.   BLOOD

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

(2011) Jung Ah Cho et al.   GYNECOLOGIC ONCOLOGY

Identification of Prognostic Molecular Features in the Reactive Stroma of Human Breast and Prostate Cancer

(2011) Anne Planche et al.   PLoS One

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

(2011) J. T. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors

(2011) Constantin Jotzu et al.   CELLULAR ONCOLOGY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Origin of carcinoma associated fibroblasts

(2010) Izhak Haviv et al.   CELL CYCLE

Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis

(2010) M Tessema et al.   ONCOGENE

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Drives an Activin A-Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions

(2009) C. Fordyce et al.   Cancer Prevention Research

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA