Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
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Title
Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Authors
Keywords
Cancer-associated fibroblasts, Heterogeneity, Immune suppression, Cancer immunotherapy
Journal
Journal of Hematology & Oncology
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-08-28
DOI
10.1186/s13045-019-0770-1
References
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Note: Only part of the references are listed.- Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
- (2019) G. Comito et al. ONCOGENE
- Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
- (2019) Jana de Sostoa et al. Journal for ImmunoTherapy of Cancer
- Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer
- (2019) Rongsheng Zhang et al. Cell Death & Disease
- Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
- (2019) Andrew J. Gunderson et al. PLoS One
- Cancer-associated fibroblasts in gastrointestinal cancer
- (2019) Hiroki Kobayashi et al. Nature Reviews Gastroenterology & Hepatology
- Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma
- (2019) Nobuhide Higashino et al. LABORATORY INVESTIGATION
- Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5
- (2019) Ziqian Li et al. INTERNATIONAL JOURNAL OF CANCER
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis
- (2019) Xueqian Zhuang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- (2018) Ana Costa et al. CANCER CELL
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- Fibroblasts in the Tumor Microenvironment: Shield or Spear?
- (2018) Twana Alkasalias et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fibroblast heterogeneity: implications for human disease
- (2018) Magnus D. Lynch et al. JOURNAL OF CLINICAL INVESTIGATION
- Phenotype molding of stromal cells in the lung tumor microenvironment
- (2018) Diether Lambrechts et al. NATURE MEDICINE
- Targeting the IL-6/JAK/STAT3 signalling axis in cancer
- (2018) Daniel E. Johnson et al. Nature Reviews Clinical Oncology
- Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
- (2018) Yusheng Cheng et al. Cell Death & Disease
- miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
- (2018) Anne-Marie Givel et al. Nature Communications
- Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
- (2018) Cheng Wang et al. Nature Communications
- Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
- (2018) Matthew A. Lakins et al. Nature Communications
- Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
- (2018) Linda Ziani et al. Frontiers in Immunology
- Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation
- (2018) Julie Jacobs et al. OncoImmunology
- Fusion of Dendritic Cells and Cancer-Associated Fibroblasts for Activation of Anti-Tumor Cytotoxic T Lymphocytes
- (2018) Liwen Qian et al. Journal of Biomedical Nanotechnology
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors
- (2018) Viviana Cremasco et al. Cancer Immunology Research
- An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
- (2018) Joshua D. Freedman et al. CANCER RESEARCH
- Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma
- (2018) Takashi Sakai et al. LUNG CANCER
- Turning foes to friends: targeting cancer-associated fibroblasts
- (2018) Xueman Chen et al. NATURE REVIEWS DRUG DISCOVERY
- TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
- (2018) Ankur Chakravarthy et al. Nature Communications
- Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
- (2018) Michael Bartoschek et al. Nature Communications
- Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
- (2017) Ying Wei et al. JOURNAL OF CLINICAL INVESTIGATION
- A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
- (2017) Anna Labernadie et al. NATURE CELL BIOLOGY
- Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
- (2017) Huipeng Li et al. NATURE GENETICS
- Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
- (2017) N Cohen et al. ONCOGENE
- FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
- (2016) Xuguang Yang et al. CANCER RESEARCH
- Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
- (2016) Heather M. Brechbuhl et al. CLINICAL CANCER RESEARCH
- Immunosuppressive activities of adenosine in cancer
- (2016) Bertrand Allard et al. CURRENT OPINION IN PHARMACOLOGY
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
- (2016) Philippe Gascard et al. GENES & DEVELOPMENT
- Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer
- (2016) Gemma Ferrer-Mayorga et al. GUT
- Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
- (2016) Gérard Zalcman et al. LANCET
- Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
- (2016) Y Deng et al. ONCOGENE
- Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
- (2016) Hideyuki Takahashi et al. Oncotarget
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2015) Berna C. Özdemir et al. CANCER CELL
- Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
- (2015) Hideyuki Takahashi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
- (2015) A. Lo et al. CANCER RESEARCH
- Akt-Girdin Signaling in Cancer-Associated Fibroblasts Contributes to Tumor Progression
- (2015) Y. Yamamura et al. CANCER RESEARCH
- Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
- (2015) Yasuhiko Ohshio et al. CANCER SCIENCE
- Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment
- (2015) Pu Li et al. CELL RESEARCH
- Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration
- (2015) I. Acerbi et al. Integrative Biology
- Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
- (2015) Kari R. Fischer et al. NATURE
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
- (2015) Jean Albrengues et al. Nature Communications
- Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment
- (2015) Luca Danelli et al. OncoImmunology
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
- (2014) M. Augsten et al. CANCER RESEARCH
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
- (2014) Mara H. Sherman et al. CELL
- Fibroblast heterogeneity in the cancer wound
- (2014) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Osteopontin mediates an MZF1–TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer
- (2014) C E Weber et al. ONCOGENE
- TGF- -inducible microRNA-183 silences tumor-associated natural killer cells
- (2014) S. S. Donatelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of the anti-tumour immune response by cancer-associated fibroblasts
- (2014) James Harper et al. SEMINARS IN CANCER BIOLOGY
- The IL-6–STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression
- (2014) Q Zhu et al. Cell Death & Disease
- Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
- (2014) Martin Augsten Frontiers in Oncology
- Fibroblast-Specific Protein 1/S100A4-Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens
- (2013) J. Zhang et al. CANCER RESEARCH
- Docetaxel Conjugate Nanoparticles That Target -Smooth Muscle Actin-Expressing Stromal Cells Suppress Breast Cancer Metastasis
- (2013) M. Murakami et al. CANCER RESEARCH
- Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer
- (2013) Ying Ma et al. CANCER RESEARCH
- Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner
- (2013) T. A. Mace et al. CANCER RESEARCH
- Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma
- (2013) Tomonari Kinoshita et al. CANCER SCIENCE
- Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
- (2013) Mercedes Herrera et al. CANCER SCIENCE
- Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
- (2013) Abasi Ene–Obong et al. GASTROENTEROLOGY
- Hepatic stellate cells in liver development, regeneration, and cancer
- (2013) Chunyue Yin et al. JOURNAL OF CLINICAL INVESTIGATION
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
- (2013) Edward W. Roberts et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity
- (2013) Tuanjie Li et al. MEDICAL ONCOLOGY
- Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
- (2013) Sunitha Kakarla et al. MOLECULAR THERAPY
- Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
- (2013) Fernando Calvo et al. NATURE CELL BIOLOGY
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
- (2013) Yoshinori Ino et al. PLoS One
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of macrophage phenotype by cell shape
- (2013) F. Y. McWhorter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
- (2013) Younghun Jung et al. Nature Communications
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein- and Heme Oxygenase-1
- (2013) J. N. Arnold et al. Cancer Immunology Research
- Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo
- (2012) S. Vicent et al. CANCER RESEARCH
- EMT and Dissemination Precede Pancreatic Tumor Formation
- (2012) Andrew D. Rhim et al. CELL
- Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
- (2012) J. S. Khalili et al. CLINICAL CANCER RESEARCH
- Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors
- (2012) Jaroslav Valach et al. INTERNATIONAL JOURNAL OF CANCER
- Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance
- (2012) Nobuyuki Fujii et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
- (2012) Sophie Dulauroy et al. NATURE MEDICINE
- FSP1+ Fibroblasts Promote Skin Carcinogenesis by Maintaining MCP-1-Mediated Macrophage Infiltration and Chronic Inflammation
- (2011) Jinhua Zhang et al. AMERICAN JOURNAL OF PATHOLOGY
- Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression
- (2011) Fieke E.M. Froeling et al. GASTROENTEROLOGY
- Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation
- (2011) Ilona Gutcher et al. IMMUNITY
- Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
- (2011) Lucia De Monte et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
- (2011) Wei Tan et al. NATURE
- Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors
- (2011) Constantin Jotzu et al. CELLULAR ONCOLOGY
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
- (2010) Neta Erez et al. CANCER CELL
- Breast Carcinoma-Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations
- (2010) A. N. Hosein et al. CANCER RESEARCH
- Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization
- (2010) N. Kobayashi et al. CANCER RESEARCH
- Autocrine TGF- and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
- (2010) Y. Kojima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-
- (2010) M. Kraman et al. SCIENCE
- Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients
- (2009) Pernilla Wikström et al. PROSTATE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- The role of endothelial-to-mesenchymal transition in cancer progression
- (2008) S Potenta et al. BRITISH JOURNAL OF CANCER
- PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity
- (2008) Irina V. Pinchuk et al. GASTROENTEROLOGY
- Stromal myofibroblasts are drivers of invasive cancer growth
- (2008) Olivier De Wever et al. INTERNATIONAL JOURNAL OF CANCER
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