Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

(2015) Yibing Hu et al.   PLoS One

Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells

(2014) B. Salimian Rizi et al.   CANCER RESEARCH

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin

(2014) Xia Xiao et al.   PLoS One

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

(2014) Lahiru Gangoda et al.   PROTEOMICS

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer

(2012) H. A. Brauer et al.   CLINICAL CANCER RESEARCH

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

(2011) Wei Zhu et al.   CANCER LETTERS

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

(2011) Yanique I. Rattigan et al.   EXPERIMENTAL CELL RESEARCH

Glutamine: pleiotropic roles in tumor growth and stress resistance

(2011) Naval P. Shanware et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Glutamine in Cancer: Therapeutic and Imaging Implications

(2011) K. N. Rajagopalan et al.   JOURNAL OF NUCLEAR MEDICINE

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts

(2009) Daniela Gaglio et al.   PLoS One

Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model

(2009) Debbie Liao et al.   PLoS One

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE